公开(公告)号：NO322155B1

公开(公告)日：2006-08-21

申请号：NO20022891

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： BOULANGER MICHELLE ,  WIERZBICKI MICHEL ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  FOURQUEZ JEAN-MARIE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D237/14 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：AT331705T

公开(公告)日：2006-07-15

申请号：AT02291192

申请日：2002-05-14

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSJEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE ,  BOULANGER MICHELLE

IPC: C07D295/10 ,  A61K31/40 ,  A61K31/426 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07D207/16 ,  C07D277/04 ,  C07D277/06 ,  C07D295/185 ,  C07K5/02 ,  C07D295/18

Abstract: Alpha amino acid derivatives (I), their optical isomers and addition salts, are new. Alpha amino acid derivatives of formula (I), their optical isomers and addition salts, are new: A = five-membered heterocycle, optionally substituted by a cyano group; Ak = 1-6C alkylene; X = single bond or phenylene; R1, R2, R4 = H or 1-6C alkyl; Y = NR4 or CH-NO2; R3 = NO2 or CN; and provided that: (i) when Y is CH-NO2, then R3 may further be 1-6C alkyl; and (ii) when A is unsubstituted, then Ak is propylene, X is a bond, Y is NH and R3 is NO2, are excluded.

公开(公告)号：ZA200405446B

公开(公告)日：2005-07-08

申请号：ZA200405446

申请日：2004-07-08

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFRIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50 ,  C07C ,  C07D ,  A61K ,  A61P

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：SI1270562T1

公开(公告)日：2004-12-31

申请号：SI200230031

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  C07D295/18 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：PT1270562E

公开(公告)日：2004-11-30

申请号：PT02291501

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOULANGER MICHELLE ,  LEVENS NIGEL ,  FOURQUEZ JEAN-MARIE ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER

IPC: A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  C07D295/18 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：BR0307465A

公开(公告)日：2004-11-09

申请号：BR0307465

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：EA004955B1

公开(公告)日：2004-10-28

申请号：EA200200574

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  A61K31/4025

Abstract: Соединениеформулы (I)вкоторойпредставляетсобойнеобязательнозамещенноенасыщенноеуглеводородноекольцо, имеющееот 4 до 8 атомовуглеродав кольце,Rи R, которыемогутбытьодинаковымиилиразличными, каждыйпредставляетсобойатомводородаилиацильнуюгруппу,Rи R, которыемогутбытьодинаковымиилиразличными, каждыйпредставляетсобойатомводородаилиалкильнуюгруппу,Rи R, которыемогутбытьодинаковымиилиразличными, каждыйпредставляетсобойатомводородаилиалкильнуюгруппу,или Rи Rсовместнос атомомазота, ихнесущим, образуютнеобязательнозамещенныйазотсодержащийгетероцикл,егостереоизомеры, атакжеегоаддитивныесолис фармацевтическиприемлемойкислотой.Лекарственныепрепараты.

公开(公告)号：NO20043532L

公开(公告)日：2004-08-24

申请号：NO20043532

申请日：2004-08-24

Applicant: SERVIER LAB

Inventor： RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  DUFLOS MURIEL ,  PFEIFFER BRUNO ,  DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  BAUT GUILLAUME LE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：EA004591B1

公开(公告)日：2004-06-24

申请号：EA200200299

申请日：2002-03-27

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  PORTEVIN BERNARD ,  BENOIST ALAIN ,  LEVENS NIGEL ,  NOSLEAN OLIVIER ,  HUSSON-ROBERT BERNADETTE

IPC: C07D295/18 ,  A61K31/40 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/5377 ,  A61K38/00 ,  A61P1/00 ,  A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07B57/00 ,  C07D207/16 ,  C07D231/04 ,  C07D233/06 ,  C07D233/48 ,  C07D277/04 ,  C07D277/06 ,  C07D277/10 ,  C07D295/22 ,  C07D403/12 ,  C07K5/062 ,  C07K5/078 ,  C07K5/087 ,  C07K5/097 ,  C07D295/185 ,  C07D295/26

Abstract: Соединениеформулы (I):вкоторойпредставляетсобой 5-членный, азотсодержащийгетероцикл,Rпредставляетсобойатомводородаилиалкильную, ацильную, пролильную, аланильную, гистидилпролильнуюилифенилаланилпролильнуюгруппу,Ak представляетсобойалкиленовуюцепьилигетероалкиленовуюцепь,Хпредставляетсобойодинарнуюсвязьилинеобязательнозамещеннуюфениленовуюгруппу,Rпредставляетсобойнеобязательнозамещеннуюалкильнуюгруппу (С-С)циклоалкильнуюгруппу, или -NRR, вкоторой Rи R, которыемогутбытьодинаковымиилиразличными, каждаяпредставляетсобойатомводорода, илилинейнуюилиразветвленную (С-С)алкильнуюгруппу, илисовместнос атомомазота, несущимих, образуютазотсодержащийгетероцикл,Y представляетсобойгруппу -NR-,Rпредставляетсобойатомводородаилигруппу, выбираемуюизалкила, (С-С)циклоалкилаи арила,R, Rи R, которыемогутбытьодинаковымиилиразличными, каждаяпредставляетсобойатомводородаилиалкильнуюгруппу, или Rи R, или Rи R, совместнос атомами, ихнесущими, образуютимидазолидиновоеилидигидробензимидазольноекольцо,ихоптическиеизомерыи ихаддитивныесолис фармацевтическиприемлемойкислотой.Лекарственныепрепараты.

公开(公告)号：AR034516A1

公开(公告)日：2004-02-25

申请号：ARP020102275

申请日：2002-06-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  A61K31/675 ,  A61K31/155 ,  A61K31/401 ,  A61K31/44

Abstract: Compuestos de la fórmula (1) donde A representa un anillo de carbono saturado opcionalmente sustitutido que tiene entre 4 y 8 miembros de anillo, R1 y R4 que pueden ser idénticos o diferentes, representan, cada uno un átomo de hidrógeno o un grupo acilo, R2 y R3 que pueden ser idénticos o diferentes, representan, cada uno, un átomo de hidrógeno o un grupo alquilo, R5 y R6, que pueden ser idénticos o diferentes, representan, cada uno un átomo de hidrógeno o un grupo alquilo, o R5 y R6 juntos, con el átomo de nitrógeno que los lleva, forman un heterociclo con contenido de nitrógeno opcionalmente sustituido, estereoisómeros de los mismos, y también, sales de adición de los mismos con un ácido farmacéuticamente aceptable. Medicamentos antidiabéticos.