Abstract:
The invention relates to a method of determining a concentration of a substance in a cell suspension, said method comprising the following steps: - determining the concentration of the substance by: - using the results of absorption measurements performed at n local sample volumes contained at different average chamber heights of a chamber arrangement comprising the cell suspension and local substance concentration in said respective local sample volumes determined based on said respective absorption measurements; - using a substance concentration model comprising local substance concentration as a function of chamber height, and - determining the substance concentration as the infinite chamber height substance concentration using said substance concentration model and the determined local substance concentrations, wherein n is at least 2, such as at least 3, such as at least 4, wherein, optionally, the cell suspension is whole blood and the substance is Hb and wherein the method further comprises determining cRBC based on the determined Hb concentration and a determined Mean Corpuscular Hemoglobin ( MCH ). The invention also relates to a system for executing the method.
Abstract:
The present invention relates to a device (1) for measuring an optical absorption property of a fluid as function of wavelength. The device comprises a broadband light source (2) for emitting light, a plurality of integrated optical waveguides (3) for guiding this light, and a light coupler (10) for coupling the emitted light into the integrated optical waveguides (3) such that the light coupled into each integrated optical waveguide (3) has substantially the same spectral distribution. The device also comprises a microfluidic channel (5) for containing the fluid, arranged such as to allow an interaction of the light propagating through each waveguide (3) with the fluid in the microfluidic channel (5). Each integrated optical waveguide (3) comprises an optical resonator (15) for filtering the light guided by the waveguide (3) according to a predetermined spectral component. The spectral component corresponding to each waveguide (3) is substantially different from the spectral component corresponding to another of the waveguides (3).
Abstract:
The present invention relates to gas sensors able to measure gas based on the absorption bands of radiation characteristic to the gas of interest, where the sensor comprises a gas measurement region. The present invention introduces the gas sensors configured and designed such, that a plural of gas sensors may be connected to form a self contained modular unit such forming a sensor construction able to measure e.g. a number of different gasses or just make a more precise measurement of one particular gas.
Abstract:
Fluid processing tube for use in optical analysis comprising at least one first portion being made from a first material suitable for optical analysis and being configured to include two optical paths of different lengths, and at least one second portion connected to said first portion and being made from a second material different from said first material.
Abstract:
조명기/수집기조립체(104)는샘플(102)에입사광(106)을전달하고샘플(102)로부터복귀하는복귀광(112)을수집할수 있다. 센서(114)는수집된복귀광(112)에대한광선위치및 광선각도의함수로서광선세기들을측정할수 있다. 광선선택기는센서(114)에서의수집된복귀광(112)으로부터, 제1 선택기준을충족하는광선들의제1 서브세트를선택할수 있다. 일부예들에서, 광선선택기는광선세기들을빈들로집합화할(aggregate) 수있으며, 각각의빈은광학적경로길이들의각각의범위내의추정된광학적경로길이를샘플(102) 내에서횡단하는, 수집된복귀광(112) 내의광선들에대응한다. 특성화기(characterizer)는광선들의제1 서브세트에대한광선세기들, 광선위치들, 및광선각도들에기초하여, 흡수율과같은샘플(102)의물리적속성을결정할수 있다. 샘플내에서횡단된광학적경로길이의변동(variation)들을고려하는것은정확성을향상시킬수 있다.