公开(公告)号：WO2002081510A3

公开(公告)日：2002-10-17

申请号：PCT/US2002/001467

申请日：2002-01-18

Applicant: CURAGEN CORPORATION ,  ANDERSON, David ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  COLMAN, Steven ,  EDINGER, Schlomit ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GUNTHER, Erik ,  KEKUDA, Ramesh ,  MACDOUGALL, John, R. ,  MEHRABAN, Fuad ,  PATTURAJAN, Meera ,  ROTHENBERG, Mark ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ANDERSON, David ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  COLMAN, Steven ,  EDINGER, Schlomit ,  ELLERMAN, Karen ,  GERLACH, Valerie ,  GUNTHER, Erik ,  KEKUDA, Ramesh ,  MACDOUGALL, John, R. ,  MEHRABAN, Fuad ,  PATTURAJAN, Meera ,  ROTHENBERG, Mark ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2002081498A3

公开(公告)日：2002-10-17

申请号：PCT/US2002/010780

申请日：2002-04-03

Applicant: CURAGEN CORPORATION ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  MALYANKAR, Uriel, M. ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir, Y. ,  LI, Li ,  VERNET, Corine, A.M. ,  ZERHUSEN, Bryan, D. ,  GORMAN, Linda ,  SHENOY, Suresh, G. ,  PENA, Carol, E., A. ,  SMITHSON, Glennda ,  BURGESS, Catherine, E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard, A. ,  GANGOLLI, Esha, A. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  JI, Weizhen ,  ANDERSON, David, W. ,  LEITE, Mario, W. ,  RASTELLI, Luca ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MACDOUGALL, John, R. ,  ROTHENBERG, Mark, E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  ELLERMAN, Karen

Inventor： GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  MALYANKAR, Uriel, M. ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir, Y. ,  LI, Li ,  VERNET, Corine, A.M. ,  ZERHUSEN, Bryan, D. ,  GORMAN, Linda ,  SHENOY, Suresh, G. ,  PENA, Carol, E., A. ,  SMITHSON, Glennda ,  BURGESS, Catherine, E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard, A. ,  GANGOLLI, Esha, A. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  JI, Weizhen ,  ANDERSON, David, W. ,  LEITE, Mario, W. ,  RASTELLI, Luca ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MACDOUGALL, John, R. ,  ROTHENBERG, Mark, E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  ELLERMAN, Karen

IPC: C12Q1/68

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

公开(公告)号：WO02070707A2

公开(公告)日：2002-09-12

申请号：PCT/US0149168

申请日：2001-12-18

Applicant: CURAGEN CORP ,  COR THERAPEUTICS INC ,  PADIGARU MURALIDHARA ,  GERLACH VALERIE L ,  SMITHSON GLENNDA ,  STONE DAVID ,  BIN-YANG RUEY ,  CONLEY PAMELA ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  KEKUDA RAMESH ,  CASMAN STACIE J ,  EDINGER SCHLOMIT ,  MACDOUGALL JOHN R

Inventor： PADIGARU MURALIDHARA ,  GERLACH VALERIE L ,  SMITHSON GLENNDA ,  STONE DAVID ,  BIN-YANG RUEY ,  CONLEY PAMELA ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  KEKUDA RAMESH ,  CASMAN STACIE J ,  EDINGER SCHLOMIT ,  MACDOUGALL JOHN R

IPC: A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  C07K16/28 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K2039/505

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO0229058A2

公开(公告)日：2002-04-11

申请号：PCT/US0131248

申请日：2001-10-05

Applicant: CURAGEN CORP ,  SHIMKETS RICHARD A ,  TAUPIER RAYMOND J JR ,  BURGESS CATHERINE E ,  ZERHUSEN BRYAN D ,  MEZES PETER S ,  RASTELLI LUCA ,  MALYANKAR URIEL M ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  SPYTEK KIMBERLY ANN ,  LI LI ,  EDINGER SHLOMIT ,  GERLACH VALERIE ,  ELLERMAN KAREN ,  MACDOUGALL JOHN ,  GUNTHER ERIK ,  MILLET ISABELLE ,  STONE DAVID ,  SMITHSON GLENNDA ,  SZEKERES EDWARD S JR

Inventor： SHIMKETS RICHARD A ,  TAUPIER RAYMOND J JR ,  BURGESS CATHERINE E ,  ZERHUSEN BRYAN D ,  MEZES PETER S ,  RASTELLI LUCA ,  MALYANKAR URIEL M ,  GROSSE WILLIAM M ,  ALSOBROOK JOHN P II ,  LEPLEY DENISE M ,  SPYTEK KIMBERLY ANN ,  LI LI ,  EDINGER SHLOMIT ,  GERLACH VALERIE ,  ELLERMAN KAREN ,  MACDOUGALL JOHN ,  GUNTHER ERIK ,  MILLET ISABELLE ,  STONE DAVID ,  SMITHSON GLENNDA ,  SZEKERES EDWARD S JR

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P3/00 ,  A61P3/04 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P13/10 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/28 ,  A61P25/32 ,  A61P27/02 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  A61P37/08 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/50 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K14/475 ,  C12N15/63 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002016600A3

公开(公告)日：2002-02-28

申请号：PCT/US2001/026518

申请日：2001-08-27

Applicant: CURAGEN CORPORATION ,  GERLACH, Valerie ,  MACDOUGALL, John, R. ,  SMITHSON, Glennda ,  STONE, David, J. ,  ELLERMAN, Karen ,  SPYTEK, Kimberly, A. ,  ZERHUSEN, Bryan, D. ,  RASTELLI, Luca ,  VERNET, Corine, A., M. ,  PATTURAJAN, Meera ,  TCHERNEV, Velizar, T. ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond, J., Jr.

Inventor： GERLACH, Valerie ,  MACDOUGALL, John, R. ,  SMITHSON, Glennda ,  STONE, David, J. ,  ELLERMAN, Karen ,  SPYTEK, Kimberly, A. ,  ZERHUSEN, Bryan, D. ,  RASTELLI, Luca ,  VERNET, Corine, A., M. ,  PATTURAJAN, Meera ,  TCHERNEV, Velizar, T. ,  PADIGARU, Muralidhara ,  TAUPIER, Raymond, J., Jr.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO1995024476A1

公开(公告)日：1995-09-14

申请号：PCT/GB1995000508

申请日：1995-03-09

Applicant: MEDICAL RESEARCH COUNCIL ,  UNIVERSITY OF READING ,  HUTCHINSON, Gillian, Ruth ,  WARD, Trevor ,  STONE, David, Michael ,  ALMOND, Jeffrey, William

Inventor： MEDICAL RESEARCH COUNCIL ,  UNIVERSITY OF READING

IPC: C12N15/10

CPC classification number: C40B40/02 ,  C07K14/705 ,  C12N15/1037 ,  C12N15/85

Abstract: The invention provides a method of amplification of DNA coding for a cellular protein such as a cell surface receptor wherein host eukaryotic cells transfected with DNA fragments comprising a DNA eukaryotic library, including DNA coding for said cellular protein, inserted in an expression vector capable of expression in the host eukaryotic cells, is contacted with a ligand specific to said cellular protein, the ligand being labelled before or after such contact, whereby individual host eukaryotic cells expressing the protein are identified and selected, the vector DNA then being subjected to cloning or other amplification, optionally after being extracted from said eukaryotic cells.

Abstract translation: 本发明提供了扩增编码细胞蛋白质如细胞表面受体的DNA的方法，其中用包含编码所述细胞蛋白的DNA的DNA片段转染的宿主真核细胞插入到能够表达的表达载体中，所述DNA片段包含DNA真核文库 在宿主真核细胞中，与所述细胞蛋白质特异性的配体接触，所述配体在所述接触之前或之后被标记，由此识别和选择表达蛋白质的单个宿主真核细胞，然后将载体DNA克隆或其他 任选地在从所述真核细胞中提取后进行扩增。

公开(公告)号：WO1992018620A1

公开(公告)日：1992-10-29

申请号：PCT/GB1992000637

申请日：1992-04-09

Applicant: BRITISH TECHNOLOGY GROUP LIMITED ,  MACADAM, Andrew, Joseph; ,  MINOR, Philip, David; ,  STONE, David, Michael ,  ALMOND, Jeffrey, William

Inventor： BRITISH TECHNOLOGY GROUP LIMITED

IPC: C12N07/04

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/13 ,  C12N7/00 ,  C12N2770/32622 ,  C12N2770/32634 ,  C12N2770/32661 ,  Y02A50/466

Abstract: A poliovirus which is either a type 3 poliovirus having amino acid residues valine and alanine at positions 54 and 114 respectively of the VP1 capsid protein or is a type 1 or type 2 poliovirus having equivalent amino acid residues at corresponding positions.

公开(公告)号：WO2013147905A1

公开(公告)日：2013-10-03

申请号：PCT/US2012/031750

申请日：2012-03-31

Applicant: INTEL CORPORATION ,  BRETON, Michael S. ,  BUSH, Wayne M. ,  STONE, David W. ,  SEDAYAO, Jeffrey C. ,  PICKERING, Cynthia K.

Inventor： BRETON, Michael S. ,  BUSH, Wayne M. ,  STONE, David W. ,  SEDAYAO, Jeffrey C. ,  PICKERING, Cynthia K.

IPC: G08B21/02 ,  G08B25/10 ,  H04W4/02 ,  H04W4/22

CPC classification number: H04W4/22 ,  G08B25/006 ,  G08G1/0965 ,  H04W4/023 ,  H04W4/026 ,  H04W4/027 ,  H04W4/046 ,  H04W4/50 ,  H04W4/90

Abstract: A method and system for notifying one or more non-emergency vehicle computing devices of an emergency event includes processing information about the emergency event received from an emergency vehicle computing device, comparing the location of the emergency vehicle to the location of the non-emergency vehicle, and sending a notification of the emergency event to the non-emergency vehicle computing devices based on the comparison.

Abstract translation: 一种用于通知一个或多个非紧急车辆计算装置的紧急事件的方法和系统包括处理关于从紧急车辆计算装置接收到的紧急事件的信息，将紧急车辆的位置与非紧急车辆的位置进行比较 ，并且基于所述比较，向所述非紧急车辆计算装置发送所述紧急事件的通知。

公开(公告)号：WO2013039562A2

公开(公告)日：2013-03-21

申请号：PCT/US2012/027741

申请日：2012-03-05

Applicant: RICOH PRODUCTION PRINT SOLUTIONS LLC ,  LEWIS, Harry, R. ,  HOHENSEE, Reinhard, H. ,  STONE, David, E.

Inventor： LEWIS, Harry, R. ,  HOHENSEE, Reinhard, H. ,  STONE, David, E.

IPC: H04N1/60 ,  G06K15/02

CPC classification number: G06F3/1208 ,  G06F3/1242 ,  G06F3/1288

Abstract: A method is disclosed. The method includes simulating a preprinted form using a presentation overlay. The presentation device is directed to present the overlay as if it had been preprinted on the paper. Document data is then mixed with the simulated preprinted form such that the result accurately simulates a real preprinted form.

Abstract translation: 公开了一种方法。 该方法包括使用演示叠加模拟预打印表单。 呈现设备被指示为将覆盖物呈现在纸张上被预先印刷。 然后将文档数据与模拟的预印形式混合，使得结果准确地模拟真实的预印形式。

公开(公告)号：WO2011100616A4

公开(公告)日：2012-03-01

申请号：PCT/US2011024630

申请日：2011-02-11

Applicant: ADC TELECOMMUNICATIONS INC ,  ANDERSON CHAD ,  KOSTECKA RYAN ,  STONE DAVID GEORGE ,  WENTWORTH MICHAEL J ,  COFFEY JOSEPH C

Inventor： ANDERSON CHAD ,  KOSTECKA RYAN ,  STONE DAVID GEORGE ,  WENTWORTH MICHAEL J ,  COFFEY JOSEPH C

IPC: H04Q1/08 ,  G02B6/44

CPC classification number: H05K7/1487 ,  G02B6/3897 ,  G02B6/428 ,  G02B6/4292 ,  G02B6/4452 ,  G02B6/4453 ,  G06F1/16 ,  G06F13/409 ,  H04Q1/023 ,  H04Q1/03 ,  H04Q1/06 ,  H04Q1/08 ,  H04Q1/13 ,  H04Q1/155 ,  H05K5/0026 ,  H05K5/0204 ,  H05K5/0217 ,  H05K7/14 ,  H05K7/1401 ,  H05K7/1489 ,  H05K7/1491 ,  Y10T29/49002 ,  Y10T29/49826

Abstract: A fiber panel system includes a chassis and at least blades configured to mount to the chassis. Each blade is moveable relative to the chassis between a retracted (closed) position and at least one extended position. Cable slack is managed at the front and/or rear of each chassis to facilitate movement of the blades without pulling or bending the cables beyond a maximum bend limit. Each blade may be locked into one or more positions relative to the chassis.

Abstract translation: 光纤面板系统包括底盘和至少配置成安装到底盘的刀片。 每个叶片在缩回（关闭）位置和至少一个延伸位置之间相对于底盘可移动。 电缆松弛在每个机架的前部和/或后部进行管理，以方便刀片的移动，而不会拉动或弯曲电缆超过最大弯曲极限。 每个叶片可以相对于底盘锁定在一个或多个位置。