公开(公告)号：DE502006007800D1

公开(公告)日：2010-10-14

申请号：DE502006007800

申请日：2006-12-13

Applicant: BASF SE

Inventor： BREUER MICHAEL

IPC: C12P17/16 ,  C07D333/16 ,  C07D333/20

公开(公告)号：DE502005007706D1

公开(公告)日：2009-08-27

申请号：DE502005007706

申请日：2005-05-04

Applicant: BASF SE

Inventor： STUERMER RAINER ,  KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL ,  SCHROEDER HARTWIG

IPC: C12P7/02 ,  C07D333/16 ,  C12N9/04 ,  C12P20060101 ,  C12P13/00 ,  C12P17/00

Abstract: The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, wherein R2, R3 and R4 independently represent H or a lower alkyl or lower alkoxy group and X− represents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and R1 are defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.

公开(公告)号：AT427996T

公开(公告)日：2009-04-15

申请号：AT05806536

申请日：2005-11-15

Applicant: BASF SE

Inventor： ST RMER RAINER ,  HAUER BERNHARD ,  DREW DEJANA ,  BREUER MICHAEL ,  SCHRIDER HARTWIG

IPC: C12P7/16 ,  C12N9/04 ,  C12P41/00

Abstract: The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.