中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

39 records (took 0.021 seconds)

    Method for producing 3-methylamino-1-(thien-2-yl)propan-1-ol
    1.
    发明专利
    Method for producing 3-methylamino-1-(thien-2-yl)propan-1-ol 审中-公开
    3-甲基氨基-1-（噻二-2-基）丙烷-1-醇的制备方法

    公开(公告)号：JP2011142908A

    公开(公告)日：2011-07-28

    申请号：JP2011005361

    申请日：2011-01-14

    Applicant: Basf Se ,  ビーエーエスエフ ソシエタス・ヨーロピアBasf Se

    Inventor： STUERMER RAINER ,  KESSELER MARIA ,  HAUER BERNHARD ,  FRIEDRICH THOMAS ,  BREUER MICHAEL

    IPC: C12N15/09 ,  C07B61/00 ,  C07D333/16 ,  C07D333/20 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/04 ,  C12N15/53 ,  C12N15/63 ,  C12P7/04 ,  C12P17/00

    CPC classification number: C07D333/16

    Abstract: PROBLEM TO BE SOLVED: To provide an enzymatic or nonenzymatic method for producing 3-methylamino-1-(thien-2-yl)propan-1-ol represented by formula (I), and further, to provide an enzyme for conducting the method, a nucleic acid sequence encoding the enzyme, an expression cassette including the nucleic acid sequence, a vector and a recombinant host organism.
    SOLUTION: The method comprises the following processes: (a) thiophene is reacted with a halogenated β-halopropionyl or halogenated acryloyl in the presence of a Lewis acid; wherein, either simultaneously or after the reaction but prior to isolating a reaction product, a hydrogen halide is passed through the reaction product to obtain a 3-halo-1-(thien-2-yl)propan-1-one; and (b) the propanone obtained in the step (a) is reduced, and subsequently, the reduced product is reacted with methylamine without isolating the reaction product as appropriate.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 待解决的问题：提供用于制备由式（I）表示的3-甲基氨基-1-（噻吩-2-基）丙-1-醇的酶或非酶法，并且还提供用于 进行该方法，编码该酶的核酸序列，包含该核酸序列的表达盒，载体和重组宿主生物。 解决方案：该方法包括以下方法：（a）在路易斯酸存在下，噻吩与卤代β-卤代丙酰基或卤代丙烯酰基反应; 其中，在反应同时或之后但在分离反应产物之前，使卤化氢通过反应产物，得到3-卤代-1-（噻吩-2-基）丙-1-酮; 和（b）步骤（a）中获得的丙酮被还原，随后将还原产物与甲胺反应，而不适当地分离反应产物。 版权所有（C）2011，JPO＆INPIT

    METHOD FOR PREPARING OPTICALLY ACTIVE HYDROXY ACID ESTERS
    2.
    发明申请
    METHOD FOR PREPARING OPTICALLY ACTIVE HYDROXY ACID ESTERS 审中-公开
    制备光学活性羟酸酯的方法

    公开(公告)号：WO2011009849A3

    公开(公告)日：2011-04-07

    申请号：PCT/EP2010060458

    申请日：2010-07-20

    Applicant: BASF SE ,  MAX PLANCK GESELLSCHAFT ,  STUERMER RAINER ,  SCHNEIDER NINA ,  BOY MATTHIAS ,  ACHATZ BRIGITTE ,  RABUS RALF ,  HEIDER JOHANN

    Inventor： STUERMER RAINER ,  SCHNEIDER NINA ,  BOY MATTHIAS ,  ACHATZ BRIGITTE ,  RABUS RALF ,  HEIDER JOHANN

    IPC: C12P7/62 ,  C12N9/04 ,  C12P7/64

    CPC classification number: C12P7/62 ,  C12N9/0008 ,  C12P7/6436

    Abstract: The invention relates to a method for preparing optically active 2-hydroxy acid ester derivatives of the formula R1-C(OH)-C(O)-O-R2 (I),comprising the bringing into contact of 2-oxo acid ester derivatives of the formula R1-C(O)-C(O)-O-R2 (II) with an enzyme (E) selected from the class of dehydrogenases, in the presence of reduction equivalents, where the compound of the formula (II) is enzymatically reduced to the compound of the formula (I), and the reduction equivalents consumed in the course of the reaction are regenerated again by converting a reducing agent (RA) to the corresponding oxidation product (OP) with the help of the enzyme (E). The invention further comprises a dehydrogenase which reduces 2-oxo acid esters in the presence of reduction equivalents to the corresponding S- 2-hydroxy acid esters, and also a nucleic acid encoding the dehydrogenase.

    Abstract translation: 本发明涉及制备式R 1 -C（OH）-C（O）-O-R 2（I）的光学活性2-羟基酸酯衍生物的方法，包括使2-氧代酸酯衍生物 在式（II）化合物的存在下，式R 1 -C（O）-C（O）-O-R 2（II））与选自脱氢酶类的酶（E） 被酶还原成式（I）的化合物，并且在反应过程中消耗的还原等价物通过在酶的帮助下将还原剂（RA）转化成相应的氧化产物（OP）再次再生（ E）。 本发明还包括在相应的S- 2-羟基酸酯的还原当量存在下还原2-氧代酸酯的脱氢酶，以及编码脱氢酶的核酸。

    METHOD FOR PRODUCING (METH)ACRYLIC ACID ESTERS CONTAINING URETHANE GROUPS
    3.
    发明申请
    METHOD FOR PRODUCING (METH)ACRYLIC ACID ESTERS CONTAINING URETHANE GROUPS 审中-公开
    用于生产聚氨酯（甲基）丙烯酸酯

    公开(公告)号：WO2010130608A2

    公开(公告)日：2010-11-18

    申请号：PCT/EP2010056079

    申请日：2010-05-05

    Applicant: BASF SE ,  STUERMER RAINER ,  DREW DEJANA ,  HAUER BERNHARD ,  DAEUWEL JUERGEN ,  MEISENBURG UWE

    Inventor： STUERMER RAINER ,  DREW DEJANA ,  HAUER BERNHARD ,  DAEUWEL JUERGEN ,  MEISENBURG UWE

    IPC: C12P7/62

    CPC classification number: C12P13/02 ,  C12P7/62

    Abstract: Method for producing (meth)acrylic acid esters (U) containing urethane groups by reacting an alcohol (A) containing urethane groups with a (meth)acrylic acid ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) having an enzyme (E) as a catalyst in a reactor, wherein a) the released saturated alcohol and the optionally used entrainer form an azeotrope with the excess corresponding (meth)acrylic acid ester (G), the azeotrope is separated by distillation at reduced pressure, and b) at least one partial flow from the sump of the reactor is recirculated via the head of the distillation column.

    Abstract translation: 一种用于通过在反应器中的催化剂的含氨基甲酸酯基的醇（A），其具有在至少一种阻聚剂（P）的存在下的饱和醇（G）的（甲基）丙烯酸酯用一种酶（E）反应来制备含氨基甲酸酯（甲基）丙烯酸酯（U）过程 其中a）所释放的饱和醇和夹带剂，如果使用的话，与过量的相应的（甲基）丙烯酸酯（G）形成Azoetrop，共沸物通过蒸馏在减压下除去，并从反应器的底部通过所述头部b）至少一个部分流 蒸馏塔再循环。

Patent Agency Ranking