公开(公告)号：AU2007310987B2

公开(公告)日：2014-01-09

申请号：AU2007310987

申请日：2007-10-18

Applicant: HARVARD COLLEGE

Inventor： VELLA SARAH JANE ,  MARTINEZ ANDRES W ,  WONG AMY ,  MIRICA KATHERINE A ,  WHITESIDES GEORGE M ,  BUTTE MANISH J ,  SINDI HAYAT ,  PHILLIPS SCOTT T ,  CARRILHO EMANUEL ,  THOMAS SAMUEL ,  LIU YANYAN

IPC: G01N33/558

Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.

公开(公告)号：DK1776181T3

公开(公告)日：2014-01-06

申请号：DK05722725

申请日：2005-01-26

Applicant: HARVARD COLLEGE

Inventor： LINDER VINCENT LINDER A ,  WHITESIDES GEORGE M ,  SIA SAMUEL K

IPC: B01J4/02 ,  B01L3/00 ,  B01L3/02 ,  B82Y30/00 ,  G01N35/10

公开(公告)号：BRPI0718473A2

公开(公告)日：2013-12-03

申请号：BRPI0718473

申请日：2007-10-18

Applicant: HARVARD COLLEGE

Inventor： WHITESIDES GEORGE M ,  PHILLIPS SCOTT T ,  MARTINEZ ANDRES W ,  BUTTE MANISH J ,  WONG AMY ,  THOMAS SAMUEL ,  SINDI HAYAT ,  VELLA SARAH JANE ,  MIRICA KATHERINE A ,  LIU YANYAN ,  CARRILHO EMANUEL

IPC: G01N33/558

公开(公告)号：CA2491564C

公开(公告)日：2013-03-19

申请号：CA2491564

申请日：2003-06-30

Applicant: HARVARD COLLEGE ,  UNIV TORONTO

Inventor： STONE HOWARD A ,  ANNA SHELLY L ,  BONTOUX NATHALIE ,  LINK DARREN ROY ,  WEITZ DAVID A ,  GITLIN IRINA ,  GARSTECKI PIOTR ,  DILUZIO WILLOW ,  WHITESIDES GEORGE M ,  KUMACHEVA EUGENIA

IPC: B01L3/00 ,  B01F25/46 ,  B05B7/04

Abstract: A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

公开(公告)号：AU2011212916A1

公开(公告)日：2012-08-16

申请号：AU2011212916

申请日：2011-02-03

Applicant: HARVARD COLLEGE

Inventor： WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  MARTINEZ ANDRES W ,  CHENG CHAO-MIN ,  PHILLIPS SCOTT T ,  MASCARENAS MONICA ,  LIU XINYU ,  LI XIUJUN

IPC: B01L3/00

Abstract: The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.

公开(公告)号：AU2010221117A1

公开(公告)日：2011-09-29

申请号：AU2010221117

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： EMANUEL CARRILHO ,  MARTINEZ ANDRES W ,  WHITESIDES GEORGE M

IPC: B01L3/00

Abstract: Methods of patterning hydrophobic regions onto hydrophilic substrates are described.

公开(公告)号：AU2010221102A1

公开(公告)日：2011-09-29

申请号：AU2010221102

申请日：2010-03-08

Applicant: HARVARD COLLEGE

Inventor： ZHIHONG NEI ,  CHRISTIAN NIJHUIS ,  XIN CHEN ,  MARTINEZ ANDRES W ,  MAX NAROVLYANSKY ,  WHITESIDES GEORGE M

IPC: B01L3/00

Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fiuidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

公开(公告)号：AU2007237368A1

公开(公告)日：2008-01-03

申请号：AU2007237368

申请日：2007-12-05

Applicant: HARVARD COLLEGE

Inventor： CHIU DANIEL T ,  CHOI INSUNG S ,  JEON NOO LI ,  WHITESIDES GEORGE M ,  DERTINGER STEPHAN K W

IPC: G01N33/53 ,  B01D3/00 ,  B01F13/00 ,  B01J19/00 ,  B01J19/24 ,  B01L1/00 ,  C12M1/34 ,  G01N33/543 ,  G01N37/00

公开(公告)号：AU2005248448B2

公开(公告)日：2007-11-29

申请号：AU2005248448

申请日：2005-12-23

Applicant: HARVARD COLLEGE

Inventor： DUFFY DAVID C ,  OSTUNI EMANUELE ,  WHITESIDES GEORGE M ,  KANE RAVI ,  JACKMAN REBECCA J

IPC: B01J19/00

公开(公告)号：AU2002213423B2

公开(公告)日：2007-09-06

申请号：AU2002213423

申请日：2001-09-18

Applicant: HARVARD COLLEGE

Inventor： WHITESIDES GEORGE M ,  CHOI INSUNG S ,  DERTINGER STEPHAN K W ,  CHIU DANIEL T ,  JEON NOO LI

IPC: G01N33/53 ,  B01D3/00 ,  B01F5/06 ,  B01F13/00 ,  B01F15/04 ,  B01J4/00 ,  B01J19/00 ,  B01J19/24 ,  B01L20060101 ,  B01L1/00 ,  B01L3/00 ,  B65B3/00 ,  B65B3/04 ,  C12M1/34 ,  C23G1/00 ,  G01F11/28 ,  G01N1/28 ,  G01N1/38 ,  G01N33/543 ,  G01N37/00

Abstract: A method and apparatus for treating a fluid. A method for treating a fluid may include combining two or more separate streams into a common stream and then splitting the common stream into a new set of separate streams wherein the separate streams may possess different properties. The separate streams may be combined to produce a gradient, such as a concentration gradient or shear gradient. The apparatus of the invention may provide a network of fluidic channels that may be used to manipulate a fluid to produce, for example, a gradient or a series of solutions containing a substance at varying concentrations.