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    Three-dimensional microfluidic devices
    1.
    发明专利
    Three-dimensional microfluidic devices 未知

    公开(公告)号：AU2009228091B2

    公开(公告)日：2015-05-21

    申请号：AU2009228091

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： MARTINEZ ANDRES W ,  CARRILHO EMANUEL ,  PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  SIEGEL ADAM C ,  MIRICA KATHERINE A ,  WILEY BENJAMIN

    IPC: G01N35/00 ,  G01N33/48

    Abstract: Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.

    PAPER-BASED MICROFLUIDIC SYSTEMS
    5.
    发明专利
    PAPER-BASED MICROFLUIDIC SYSTEMS 未知

    公开(公告)号：CA2719800A1

    公开(公告)日：2009-10-01

    申请号：CA2719800

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    IPC: G01N35/00 ,  G01N27/26 ,  G01N33/48

    Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

    MICROFLUIDIC, ELECTROMECHANICAL DEVICES
    8.
    发明专利
    MICROFLUIDIC, ELECTROMECHANICAL DEVICES 未知

    公开(公告)号：CA2754577A1

    公开(公告)日：2010-09-10

    申请号：CA2754577

    申请日：2010-03-08

    Applicant: HARVARD COLLEGE

    Inventor： NIE ZHIHONG ,  NIJHUIS CHRISTIAN ,  CHEN XIN ,  MARTINEZ ANDRES W ,  NAROVLYANSKY MAX ,  WHITESIDES GEORGE M

    IPC: B01L3/00

    Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fiuidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    THREE-DIMENSIONAL MICROFLUIDIC DEVICES
    9.
    发明专利
    THREE-DIMENSIONAL MICROFLUIDIC DEVICES 未知

    公开(公告)号：CA2719320A1

    公开(公告)日：2009-10-01

    申请号：CA2719320

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  MIRICA KATHERINE A ,  PHILLIPS SCOTT T ,  SIEGEL ADAM C ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M

    IPC: G01N35/00 ,  G01N33/48

    Abstract: Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.

    Three-dimensional microfluidic devices
    10.
    发明专利
    Three-dimensional microfluidic devices 未知

    公开(公告)号：AU2009228091A1

    公开(公告)日：2009-10-01

    申请号：AU2009228091

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE

    Inventor： WHITESIDES GEORGE M ,  CARRILHO EMANUEL ,  MIRICA KATHERINE A ,  SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  MARTINEZ ANDRES W ,  WILEY BENJAMIN

    IPC: G01N35/00 ,  G01N33/48

    Abstract: Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.

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