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    81.
    发明专利
    未知

    公开(公告)号：SE385886B

    公开(公告)日：1976-07-26

    申请号：SE187472

    申请日：1972-02-16

    Applicant: HOECHST AG

    Inventor： WEYER R ,  AUMULLER W ,  SCHWEITZER R ,  WEBER H ,  HUBNER M

    IPC: A61K31/18 ,  A61K31/47 ,  A61K31/505 ,  C07D215/14 ,  C07D215/48 ,  C07D239/42 ,  C07D239/69 ,  C07D401/12 ,  C07D239/44

    Abstract: 1377793 Benzenesulphonamido-pyrimidines FARBWERKE HOECHST AG 17 Feb 1972 [17 Feb 1971] 7398/72 Heading C2C Novel compounds (I) (including salts thereof) where X is H, Cl, Br, Me or MeO, Y signifies -CHMeCH 2 - or -CH 2 -CH 2 -; R is H or together with Y is a 3 or 4 C bridge, R 1 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, alkoxy, cycloalkoxy, alkoxyalkyl, alkoxyalkoxy, alkylmercapto or alkylmercaptoalkyl, R 11 is H or alkyl and R 1 and R 11 together represent C 3 to C 5 alkylene, are made by standard methods. The preparations of 4-(#-quinoline-8-carboxamido - ethyl) - benzenesulphochloride and of compounds VIII are also described. Pharmaceutical preparations showing hypoglycemic action contain (I) as active ingredient; administration is, e.g. orally.

    89.
    发明专利
    未知

    公开(公告)号：NO127707B

    公开(公告)日：1973-08-06

    申请号：NO315269

    申请日：1969-07-31

    Applicant: HOECHST AG

    Inventor： WEYER R ,  AUMUELLER W ,  WEBER H ,  MUTH K ,  SCHMIDT F

    IPC: C07C311/58 ,  C07C303/36 ,  C07C303/38 ,  C07C311/59 ,  C07D233/96 ,  C07D333/20 ,  C07C143/78

    Abstract: 1,233,354. Benzenesulphonyl-ureas. FARBWERKE HOECHST A.G. 14 Feb., 1969 [2 Aug., 1968], No. 8218/69. Heading C2C. Novel compounds I (including salts thereof) wherein X signifies the groups II or III in which R signifies C 1-4 alkyl, Z signifies halogen, C 1-4 alkyl or C 1-4 alkoxy and Z 1 signifies halogen or C 1-4 alkyl are obtained according to standard methods. N - [4 - (# - Aminoethyl) - benzenesulphonyl]. N 1 - (# 2 - cyclohexenyl) - urea is prepared by saponifying the #-acetamidoethyl-compound. 1 - [4 - (# - - ethyl) - benzenesulphonyl] - 3 - (#2. cyclohexenyl)-parabanic acid is prepared by the interaction of 1-(#2-cyclohexenyl)-parabanic acid and 4 - (# - - ethyl) - benzenesulphochloride. #2 - Cyclohexenyl isocyanate is prepared by heating N - (#2 - cyclohexenyl) - N 1 ,N 1 - diphenyl-urea. The cyclohexenylamine salt of N-[4 - (# - - ethyl) - benzenesulphonyl] - N 1 - aceryl - urea is obtained by mixing the individual compounds and heating. N - (#2 - Cyclohexenyl) - carbamic acid phenyl ester is prepared by the interaction of phenyl chloroformate and #2-cyclohexenylamine. N - Acetyl - N 1 - (#2 - cyclohexenyl) - urea is prepared by the interaction of acetic anhydride and #2-cyclohexenyl-urea. N,N - Diphenyl - N 1 - (#2 - cyclohexenyl)- urea is prepared from diphenyl carbamoyl chloride and #2-cyclohexenylamine. N,N 1 - Di - (#2 - cyclohexenyl) - urea is prepared from #2 - cyclohdxenyl isocyanate and #2-cyclohexenylamine. N - [4 - (# - - ethyl) - benzenesulphonyl] - phenylurethane, -N 1 N 1 - diphenyl - urea, - iminodithio - carbonic acid potassium salt and dimethyl ester, -N 1 - (#2 - cyclohexenyl) - isothiourea methyl ether, -N 1 -(#2-cyclohexenyl)- thiourea and - N 1 - (#2 - cyclohexenyl) - isourea methyl ether and 4-(#- - ethyl) - benzene sulphonamide are also prepared as intermediates. Pharmaceutical preparations exhibiting blood sugar lowering properties and hypoglycemic activity contain I as active ingredient; administration is orally.

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