公开(公告)号：DK2151427T3

公开(公告)日：2013-04-02

申请号：DK09290605

申请日：2009-08-04

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C231/02 ,  C07C209/48 ,  C07C231/10 ,  C07C233/18

公开(公告)号：PT2151427E

公开(公告)日：2013-01-22

申请号：PT09290605

申请日：2009-08-04

Applicant: SERVIER LAB

Inventor： PASCAL BONTEMPELLI ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C231/02 ,  C07C209/48 ,  C07C231/10 ,  C07C233/18

公开(公告)号：GEP20115345B

公开(公告)日：2011-12-12

申请号：GEAP2009011401

申请日：2009-08-03

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C233/18 ,  C07C209/48 ,  C07C231/02 ,  C07C231/10

Abstract: There is provided a new method for industrial synthesisof agomelatine of the formula (I) (I) in which as an initial compound (7-methoxy-1-naphtyl) acetonitrile is used, which is subjected to a reduction by hydrogen in the presence of Raney nickel in medium containing acetic anhydride in a polar protic medium.

公开(公告)号：AP2009004935A0

公开(公告)日：2009-08-31

申请号：AP2009004935

申请日：2009-07-27

Applicant: SERVIER LAB

Inventor： SERY JEAN-PIERRE ,  BONTEMPELLI PASCAL ,  STARCK JEROME-BENOIT

IPC: A61K31/00

Abstract: Process for industrial synthesis of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (agomelatine) (I) comprises reacting (7-methoxy-1-naphtyl)acetonitrile, which is subjected to a reduction by hydrogen in the presence of Raney nickel in medium containing acetic anhydride in a polar protic medium to give (I) that is isolated as a solid. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.

公开(公告)号：CA3183613A1

公开(公告)日：2021-11-25

申请号：CA3183613

申请日：2021-05-18

Applicant: SERVIER LAB

Inventor： DESOS PATRICE ,  FRANZETTI GEORGES-ALAIN ,  STARCK JEROME-BENOIT ,  KOSTOVA VESELA

IPC: A61K47/68

Abstract: The present invention relates to para-amino-benzyl linker compounds useful for linking drug moieties to antibodies, to linker-drug compounds in which said para-amino-benzyl linker compounds are covalently linked to drug moieties, and to antibody-drug conjugates in which said para-amino-benzyl linker compounds are covalently linked to drug wherein said drug is enzymatically cleaved from the conjugate at a particular cell or tissue type targeted by said antibody.

公开(公告)号：CO7010833A2

公开(公告)日：2014-07-31

申请号：CO14155949

申请日：2014-07-18

Applicant: SERVIER LAB

Inventor： LE DIGUARHER THIERRY ,  CASARA PATRICK ,  STARCK JEROME-BENOIT ,  HENLIN JEAN MICHAEL ,  DAVIDSON JAMES EDWARD PAUL ,  MURRAY JAMES ,  GRAHAM CHRISTOPHER JOHN ,  CHEN I-JEN ,  GENESTE OLIVIER ,  HICKMAN JOHN ,  DEPIL STEPHANE ,  LE TIRAN ARNAUD ,  NYERGES MIKLOS ,  DE NANTEUIL GUILLAUME

IPC: C07D471/00

公开(公告)号：HK1141006A1

公开(公告)日：2010-10-29

申请号：HK10107581

申请日：2010-08-09

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C20060101

Abstract: Process for industrial synthesis of N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide (agomelatine) (I) comprises reacting (7-methoxy-1-naphtyl)acetonitrile, which is subjected to a reduction by hydrogen in the presence of Raney nickel in medium containing acetic anhydride in a polar protic medium to give (I) that is isolated as a solid. ACTIVITY : Antidepressant; Hypnotic; Cardiovascular-Gen.; Gastrointestinal-Gen.; CNS-Gen.; Muscular-Gen.; Eating-Disorders-Gen.; Anorectic. MECHANISM OF ACTION : 5-Hydroxytryptamine 2C receptor antagonist.

公开(公告)号：PH12014000179B1

公开(公告)日：2016-01-18

申请号：PH12014000179

申请日：2014-06-25

Applicant: SERVIER LAB ,  VERNALIS (R AND D) LTD

Inventor： LE TIRAN ARNAUD ,  LE DIGUARHER THIERRY ,  STARCK JEROME-BENOIT ,  HENLIN JEAN-MICHEL ,  GUILLOUZIC ANNE-FRANCOISE ,  DE NANTEUIL GUILLAUME ,  GENESTE OLIVIER ,  FEJES IMRE ,  TATAI JANOS ,  NYERGES MIKLOS ,  DAVIDSON JAMES EDWARD PAUL ,  MURRAY JAMES BROOKE ,  CHEN I-JEN ,  DURAND DIDIER

IPC: C07D491/107 ,  A61K31/397 ,  A61K31/47 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K41/00 ,  A61K45/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/02 ,  A61P43/00 ,  C07D401/10 ,  C07D401/14 ,  C07D409/14 ,  C07D471/04 ,  C07D498/04

Abstract: The present invention relates to a new pyrrole compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5, and T are as defined in the description, to a process for their preparation and to pharmaceutical compositions containing them.

公开(公告)号：PH12014000179A1

公开(公告)日：2016-01-18

申请号：PH12014000179

申请日：2014-06-25

Applicant: VERNALIS R AND D LTD ,  SERVIER LAB

Inventor： TIRAN ARNAUD LE ,  DIGUARHER THIERRY LE ,  STARCK JEROME-BENOIT ,  HENLIN JEAN-MICHEL ,  GUILLOUZIC ANNE-FRANCOISE ,  NANTEUIL GUILLAUME DE ,  GENESTE OLIVER ,  FEJES IMRE ,  TATAI JANOS ,  NYERGES MIKLOS ,  DAVIDSON JAMES EDWARD PAUL ,  MURRAY JAMES BROOKE ,  CHEN I-JEN ,  DURAND DIDIER

IPC: A61K31/407 ,  A61K31/4353 ,  A61K31/437 ,  C07D471/00 ,  C07D471/04

Abstract: The present invention relates to a new pyrrole compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5, and T are as defined in the description, to a process for their preparation and to pharmaceutical compositions containing them.

公开(公告)号：AU2009203052B2

公开(公告)日：2013-09-05

申请号：AU2009203052

申请日：2009-07-27

Applicant: SERVIER LAB

Inventor： BONTEMPELLI PASCAL ,  JALENQUES XAVIER ,  STARCK JEROME-BENOIT ,  SERY JEAN-PIERRE

IPC: C07C233/18 ,  C07C231/06 ,  C07C255/37

Abstract: NEW PROCESS FOR THE SYNTHESIS OF AGOMELATINE Abstract The invention relates to a process for the industrial synthesis of the compound of formula (1) NHCOMe MeO