Patent search ap:("SERVIER LAB") AND inv:"CASARA PATRICK" Page 1

1.

发明专利
NEW CYCLOHEPTENE COMPOUND, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开

公开(公告)号：JP2002265448A

公开(公告)日：2002-09-18

申请号：JP2002009645

申请日：2002-01-18

Applicant: SERVIER LAB

Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , DOREY GILBERT , HICKMAN JOHN , PIERRE ALAIN , TUCKER GORDON , GUILBAUD NICOLAS

IPC: C07C317/00 , A61K31/4164 , A61K31/417 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K31/454 , A61P9/00 , A61P9/10 , A61P25/00 , A61P35/00 , C07D213/36 , C07D213/38 , C07D213/57 , C07D233/54 , C07D233/58 , C07D233/61 , C07D233/64 , C07D401/06

Abstract: PROBLEM TO BE SOLVED: To provide a compound having a specific structure, selectively inhibiting FTase with respect to GGTase and useful for the treatment of diseases relating to the intracellular signal transduction through Ras protein, etc., and the investigation of pathology relating to angiogenetic amplification. SOLUTION: The objective compound is expressed by formula (I) [X is a bond, an alkylene, S(O)n or the like; Y is an aryl, a heteroaryl or the like; R1 to R4 are each independently H, an aryl or the like or together form a bond, a condensed benzene ring or the like; T is CH(R5 ) (R5 is H or the like) or the like; V is H, a substituted aryl or the like; A2 is [C(R6 ) (R'6 )] (R6 and R'6 are each H or the like; and (p) is 0-4); and R7 and R8 are each H or the like]. The invention further relates to its isomer, diastereomer, pharmacologically permissible acid or base and its addition salt.

2.

发明申请
AZABICYCLO[3.1.0]HEX-2-YL DERIVATIVES, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
Title translation: 亚氨基胆碱[3.1.0] HEX-2-YL衍生物，其制备方法和含有其的药物组合物

公开(公告)号：WO2011070253A8

公开(公告)日：2012-08-02

申请号：PCT/FR2010000823

申请日：2010-12-08

Applicant: SERVIER LAB , CASARA PATRICK , CHOLLET ANNE-MARIE , DHAINAUT ALAIN , HENLIN JEAN-MICHEL , LESTAGE PIERRE , PANAYI FANY

Inventor： CASARA PATRICK , CHOLLET ANNE-MARIE , DHAINAUT ALAIN , HENLIN JEAN-MICHEL , LESTAGE PIERRE , PANAYI FANY

IPC: C07D209/52 , A61K31/403 , A61P25/00

CPC classification number: C07D209/52

Abstract: The invention relates to the compounds of formula (I), where: ALK is an alkylene chain, and W is a grouping of formula (II) or formula (III), where R and R' are as defined in the description. The invention can be used as a drug.

Abstract translation: 本发明涉及式（I）化合物，其中：ALK是亚烷基链，W是式（II）或式（III）的基团，其中R和R'如说明书中所定义。本发明可用作药物。

3.

发明申请
COMPOUNDS AZEPANE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS 审中-公开
Title translation: 化合物AZEPANE，其制备方法及含有化合物的药物组合物

公开(公告)号：WO02057223A3

公开(公告)日：2002-11-28

申请号：PCT/FR0200147

申请日：2002-01-16

Applicant: SERVIER LAB , CASARA PATRICK , LE DIGUARHER THIERRY , DOREY GILBERT , HICKMAN JOHN , PIERRE ALAIN , TUCKER GORDON , GUILBAUD NICOLAS , ORTUNO JEAN-CLAUDE , FAUCHERE JEAN-LUC

Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , DOREY GILBERT , HICKMAN JOHN , PIERRE ALAIN , TUCKER GORDON , GUILBAUD NICOLAS , ORTUNO JEAN-CLAUDE , FAUCHERE JEAN-LUC

IPC: A61P35/00 , C07D401/14 , C07D403/12 , C07D413/12 , A61K31/415 , C07D401/12

CPC classification number: C07D401/14 , C07D403/12 , C07D413/12

Abstract: A compound having formula (I), wherein X denotes an alkylene group or chain, CO, S(O)n, -S(O)n-A1-, -CO-A1-, -A1-S(O)n-A'1, or A1-CO-A'1-; Y denotes a substituted or non-substituted aryl, heteroaryl, cycloalkyl or heterocyclalkyl group; W denotes a CO or CH2 group; T denotes a N(R1)- or N(R1)CO- group; V denotes a hydrogen atom or a substituted or non-substituted aryl or heteroaryl group; A2 denotes a [C(R2)(R'2)]p group; R1 and R2 are as defined in the description. Medicaments.

Abstract translation: 具有式（I）的化合物，其中X表示亚烷基或链，CO，S（O）n，-S（O）n -A1，-CO-A1-，-A1-S（O） A'1或A1-CO-A'1-; Y表示取代或未取代的芳基，杂芳基，环烷基或杂环烷基; W表示CO或CH 2基团; T表示N（R1） - 或N（R1）CO-基团; V表示氢原子或取代或未取代的芳基或杂芳基; A2表示[C（R2）（R'2）] p基团; R1和R2如说明书中所定义。药物。

4.

发明申请
NOVEL TRICYCLIC DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
Title translation: 新型三环衍生物及其制备方法和含有该组分的药物组合物

公开(公告)号：WO2010007248A3

公开(公告)日：2010-04-08

申请号：PCT/FR2009000855

申请日：2009-07-10

Applicant: SERVIER LAB , CASARA PATRICK , LE DIGUARHER THIERRY , DURAND DIDIER , GENESTE OLIVIER , HICKMAN JOHN

Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , DURAND DIDIER , GENESTE OLIVIER , HICKMAN JOHN

IPC: C07D471/04 , A61K31/498 , A61K31/4985 , A61P35/00 , C07D207/20 , C07D211/70 , C07D213/36 , C07D241/04 , C07D471/14 , C07D487/04

CPC classification number: C07D471/04 , C07D487/04

Abstract: Compounds of formula (I) in which: A is a (hetero)aromatic or non-(hetero)aromatic ring containing 5, 6 or 7 ring members, Z1, Z2 and Z3 are, independently of one another, a CH group or a nitrogen atom, with at least one of these three groups being a nitrogen atom, X is an alkylene chain as defined in the description, R2 is an aryl or heteroaryl group, and the R1 group is a group of formula (II) as defined in the description.

Abstract translation: 式（I）化合物，其中：A是含有5,6或7个环成员的（杂）芳族或非（杂）芳族环，Z 1，Z 2和Z 3彼此独立地是CH基团或氮原子，并且这三个基团中的至少一个是氮原子，X是如说明书中所定义的亚烷基链，R 2是芳基或杂芳基，并且R 1基团是如上定义的式（II）的基团说明。