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公开(公告)号：AU2014294866B2
公开(公告)日：2018-09-27
申请号：AU2014294866
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
Abstract: The invention relates to compounds of formula (I), wherein R
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公开(公告)号：SI3027602T1
公开(公告)日：2018-08-31
申请号：SI201430784
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/00 , A61K31/00 , A61P35/00 , A61P37/00 , C07D405/00 , C07D471/00
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公开(公告)号：EA028609B1
公开(公告)日：2017-12-29
申请号：EA201600121
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
Abstract: Соединенияформулы (I)вкоторой R, R, R, R, R, R, R, A, A, T и W являютсятакими, какопределенов описании. Лекарственныесредства.
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公开(公告)号：PL2807159T3
公开(公告)日：2017-04-28
申请号：PL13704189
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/04 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D487/04 , C07D491/052
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公开(公告)号：DK2807159T3
公开(公告)日：2017-02-27
申请号：DK13704189
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LETIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME , LE DIGUARHER THIERRY , CASARA PATRICK
IPC: C07D471/04 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D487/04 , C07D491/052
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Patent Agency Ranking
公开(公告)号：HK1203507A1
公开(公告)日：2015-10-30
申请号：HK15104233
申请日：2015-05-04
Applicant: SERVIER LAB
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JRME-BENOT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D20060101 , A61K20060101 , A61P20060101
Abstract: wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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公开(公告)号：DK3027602T3
公开(公告)日：2018-09-24
申请号：DK14758604
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： HENLIN JEAN-MICHEL , LETIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , WALMSLEY CLAIRE , CASARA PATRICK , CHEN I-JEN , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
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8.发明专利
公开(公告)号：MD4490C1
公开(公告)日：2018-01-31
申请号：MD20140084
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Invenţia se referă la noi compuşi indolizinici care pot fi utilizaţi în tratamentul bolilor oncologice şi celor legate de apoptoză.Se revendică compuşi cu formula (I) şi un procedeu de obţinere a lor:unde Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5,, X, Y şi Het sunt definiţi în descriere.De asemenea se revendică compoziţii farmaceutice care conţin un compus cu formula (I) sau o sare de adiţie a acestuia cu un acid sau o bază acceptabilă farmaceutic; şi utilizarea compoziţiilor farmaceutice respective în fabricarea medicamentelor.Revendicări: 24
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公开(公告)号：ME02601B
公开(公告)日：2017-06-20
申请号：MEP201728
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: A61K31/4353 , A61K31/407 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
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10.发明专利
公开(公告)号：AU2013213474B2
公开(公告)日：2017-06-08
申请号：AU2013213474
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JEROME-BENOIT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STEPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Compounds of formula (I) wherein R
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