公开(公告)号：AU744104B2

公开(公告)日：2002-02-14

申请号：AU8189998

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00

Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.

公开(公告)号：NZ331523A

公开(公告)日：2000-02-28

申请号：NZ33152398

申请日：1998-08-24

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  A61K31/395 ,  C07D223/18 ,  C07D223/20

Abstract: 7-phenyl-1,4-diazepane derivatives of the formula 1 R1 is H or lower alkyl R2 is H, lower alkyl, lower alkoxy, halogen or CF3 R3 is H, lower alkyl, lower alkoxy, halogen or CF3 R2 and R3 together are alkylenedioxy with 1-2-carbon atoms, bonded to adjacent carbon atoms of the phenyl ring R4 is H, lower alkyl, lower alkoxy, halogen or CF3 R5 is lower alkyl, H, lower alkoxy, halogen or CF3 R4 and R5 together are alkylenedioxy with 1-2-carbon atoms, bonded to adjacent carbon atoms of the phenyl ring R6 is lower alkyl, halogen, or CF3 R7 is lower alkyl, halogen or CF3 A is a -(CH2)n- group where n = 1-3 or -NH-(CH2)m- where m is 2 -3 B is an alkylene chain with 1-3-carbon atoms optionally substituted by lower alkyl Or a physiologically compatible acid addition salt thereof. Also claimed is a process for preparation of these compounds for treating prophylaxis of a pathological condition induced by neurokinin.

公开(公告)号：BR9803250A

公开(公告)日：2000-02-08

申请号：BR9803250

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：TR9801683A2

公开(公告)日：1999-03-22

申请号：TR9801683

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKHER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  C07D

CPC classification number: C07D209/14 ,  Y02P20/55

公开(公告)号：TR199801683A2

公开(公告)日：1999-03-22

申请号：TR9801683

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKHER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  C07D

Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.

公开(公告)号：CZ267198A3

公开(公告)日：1999-03-17

申请号：CZ267198

申请日：1998-08-21

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00

Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.

公开(公告)号：AU8190098A

公开(公告)日：1999-03-11

申请号：AU8190098

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  ZIEGELER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：NO983919L

公开(公告)日：1999-03-01

申请号：NO983919

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  A61K31/395

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：NO983919A

公开(公告)日：1999-03-01

申请号：NO983919

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  A61K31/395

CPC classification number: C07D243/08 ,  Y02P20/55

公开(公告)号：NO983918D0

公开(公告)日：1998-08-26

申请号：NO983918

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  C07D

Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.