公开(公告)号：AU781333B2

公开(公告)日：2005-05-19

申请号：AU5064402

申请日：2002-06-26

Applicant: SOLVAY PHARM GMBH

Inventor： SCHON UWE ,  MESSINGER JOSEF ,  BRUCKNER REINHARD ,  ZIEGLER DIETER

IPC: A61K31/435 ,  A61K31/439 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D471/10 ,  A61K31/403

Abstract: 7-Alkyl-3-(substituted phenyl)-9,9-(dialkyl or alkylene)-3,7-diazabicyclo (3.3.1) nonane derivatives (I) are new. Diazabicyclononane derivatives of formula (I) and their acid addition salts are new. R1 = 1-6C alkyl or 4-7C cycloalkylalkyl; R2, R3 = 1-4C alkyl; or R2 + R3 = 3-6C alkylene; and R4 = phenyl (monosubstituted in the ortho- or para-position by NO2, CN or 2-5C alkanoyl) or 2,4-dinitrophenyl. An Independent claim is also included for the preparation of (I).

公开(公告)号：HK1051860A1

公开(公告)日：2003-08-22

申请号：HK03104135

申请日：2003-06-11

Applicant: SOLVAY PHARM GMBH

Inventor： SCHON UWE ,  MESSINGER JOSEF ,  BRUCKNER REINHARD ,  ZIEGLER DIETER

IPC: C07D20060101 ,  A61K31/435 ,  A61K31/439 ,  A61P20060101 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D471/10

Abstract: 7-Alkyl-3-(substituted phenyl)-9,9-(dialkyl or alkylene)-3,7-diazabicyclo (3.3.1) nonane derivatives (I) are new. Diazabicyclononane derivatives of formula (I) and their acid addition salts are new. R1 = 1-6C alkyl or 4-7C cycloalkylalkyl; R2, R3 = 1-4C alkyl; or R2 + R3 = 3-6C alkylene; and R4 = phenyl (monosubstituted in the ortho- or para-position by NO2, CN or 2-5C alkanoyl) or 2,4-dinitrophenyl. An Independent claim is also included for the preparation of (I).

公开(公告)号：CA2391915A1

公开(公告)日：2002-12-28

申请号：CA2391915

申请日：2002-06-27

Applicant: SOLVAY PHARM GMBH

Inventor： SCHOEN UWE ,  ZIEGLER DIETER ,  BRUECKNER REINHARD ,  MESSINGER JOSEF

IPC: A61K31/435 ,  A61K31/439 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08 ,  C07D471/10 ,  C07D471/18 ,  A61K31/438 ,  A61K31/46

Abstract: Pharmacologically active compounds of the general formula I (see formula I) wherein R1 is an alkyl group with 1 - 6 carbon atoms or a cycloalkylalkyl group with 4 - 7 carbon atoms, R2 is lower alkyl and R3 is lower alkyl or R2 and R3 together form an alkylene chain with 3 - 6 carbon atoms, R4 stands for a phenyl radical monosubstituted in the ortho or para position by nitro, cyano or lower alkanoyl or disubstituted in the ortho and para position by nitro, and their physiologically compatible acid addition salts are described.

公开(公告)号：CZ289245B6

公开(公告)日：2001-12-12

申请号：CZ86396

申请日：1996-03-22

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOLTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMAHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078

Abstract: In the present invention there are disclosed NEP-inhibiting derivatives of benzazepine-, benzoxazepine- and benzothiazepine-N-acetic acid of the general formula I, in which Re1 represents an alkoxyalkyl group having 1 to 4 carbon atoms in both alkoxy and alkyl moieties and the alkoxy radical containing 1 to 4 carbon atoms of which is substituted with an alkoxy group having 1 to 4 carbon atoms, further a phenylalkyl or phenyloxyalkyl group containing 1 to 4 carbon atoms in the alkyl moiety and which can be optionally substituted on the phenyl ring with either alkyl containing 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms or a halogen, or it represents a naphthylalkyl group containing 1 to 4 carbon atoms in the alkyl moiety, A represents CHi2, oxygen or sulfur, Re2 represents hydrogen or halogen, Re3 represents hydrogen or halogen, Re4 represents hydrogen or some of biologically labile, ester-forming groups and Re5 represents hydrogen or some of biologically labile, ester-forming groups, and physiologically acceptable salts of the acids of the general formula I as well as medicament containing these derivatives.

公开(公告)号：ES2152444T3

公开(公告)日：2001-02-01

申请号：ES96104265

申请日：1996-03-18

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOLTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMAHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：DK0733642T3

公开(公告)日：2001-01-15

申请号：DK96104265

申请日：1996-03-18

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOELTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMOHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：AT197801T

公开(公告)日：2000-12-15

申请号：AT96104265

申请日：1996-03-18

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOELTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMAEHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：NO305904B1

公开(公告)日：1999-08-16

申请号：NO961181

申请日：1996-03-22

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOELTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMOHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078 ,  C07D233/16 ,  C07D233/57 ,  A61K31/40 ,  A61K31/445

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.

公开(公告)号：CA2279965A1

公开(公告)日：1998-08-13

申请号：CA2279965

申请日：1998-02-02

Applicant: SOLVAY PHARM GMBH

Inventor： SINNER ERNST ,  GUNDLACH FRANK ,  MESSINGER JOSEF

IPC: B01D15/00 ,  B01D15/08 ,  G01N30/46

Abstract: The invention relates to a device or equipment as well as to a method for the simultaneous, fractionating operation of a plurality of parallel chromatographic columns. It is particularly advantageous to apply this equipment and method in research, in the framework of organic synthesis for simultaneous, parallel separation, isolation and purification of a plurality of chemical compounds, e.g. of potential new active ingredients for medicaments, particularly also on the semi-preparative scale.

公开(公告)号：AU4821096A

公开(公告)日：1996-10-03

申请号：AU4821096

申请日：1996-03-21

Applicant: SOLVAY PHARM GMBH

Inventor： WALDECK HARALD ,  HOLTJE DAGMAR ,  MESSINGER JOSEF ,  ANTEL JOCHEN ,  WURL MICHAEL ,  THORMAHLEN DIRK

IPC: C07D223/16 ,  A61K31/33 ,  A61K31/423 ,  A61K31/428 ,  A61K31/55 ,  A61K31/554 ,  A61K38/00 ,  A61K38/05 ,  A61P7/10 ,  A61P9/00 ,  A61P43/00 ,  C07D267/14 ,  C07D281/10 ,  C07K5/078 ,  C07D405/12

Abstract: Benzazepin-, benzoxazepin- and benzothiazepin-N-acetic acid derivs. of formula (I) and their salts are new. R = lower alkoxy(lower)alkyl (in which the alkoxy is opt. substd. by lower alkoxy) or phenyl(lower)alkyl, or phenoxy(lower)alkyl (opt. ring substd. by lower alkyl or alkoxy or halo) or naphthyl(lower)alkyl; A = CH2, O or S; R , R = H or halogen; R , R = H or a biolabile ester containing gp.