公开(公告)号：PL344043A1

公开(公告)日：2001-09-24

申请号：PL34404399

申请日：1999-05-10

Applicant: SOLVAY PHARM GMBH

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10 ,  C07C7/10

Abstract: A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate products of this method and to novel azacyclenes.

公开(公告)号：NO20005666L

公开(公告)日：2000-11-10

申请号：NO20005666

申请日：2000-11-10

Applicant: SOLVAY PHARM GMBH

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10

Abstract: A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate products of this method and to novel azacyclenes.

公开(公告)号：AU1643899A

公开(公告)日：1999-08-26

申请号：AU1643899

申请日：1999-02-12

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  EECKHOUT CHRISTIAN ,  PREUSCHOFF ULF

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P1/14 ,  A61P43/00 ,  C07H17/08

Abstract: (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-Pentamethyl-11-acetyl-12,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds are new. (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-pentamethyl-11-acetyl-12,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds of formula (I) and their acid addition salts are new R1 = H or Me; R2 = H or lower alkanoyl.

公开(公告)号：NO990675L

公开(公告)日：1999-08-16

申请号：NO990675

申请日：1999-02-12

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P1/14 ,  A61P43/00 ,  C07H17/08

Abstract: (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-Pentamethyl-11-acetyl-12,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds are new. (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-pentamethyl-11-acetyl-12,13- dioxabicyclo(8.2.1)tridec-8-en-1-one compounds of formula (I) and their acid addition salts are new R1 = H or Me; R2 = H or lower alkanoyl.

公开(公告)号：CZ310697A3

公开(公告)日：1998-06-17

申请号：CZ310697

申请日：1997-10-01

Applicant: SOLVAY PHARM GMBH

Inventor： HOLTJE DAGMAR ,  PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN ,  FINNER EMIL

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P43/00 ,  C07H17/08 ,  A61K31/365

Abstract: Ä(1'R),2R,3S,4S,5R,6R,9R,11R,12R,14RÜ-11-(1'-hydroxypropyl)-2,4,6,8,11 ,14-hexamethyl-10,13,15-trioxatricycloÄ9.2.1.1 Ü pentadecan-1-one derivatives of formula (I) and their salts are new: R = H or Me.

公开(公告)号：CA2219311A1

公开(公告)日：1998-04-24

申请号：CA2219311

申请日：1997-10-24

Applicant: SOLVAY PHARM GMBH

Inventor： PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN ,  FINNER EMIL ,  HOELTJE DAGMAR

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P43/00 ,  C07H17/08

Abstract: Ring-contracted N-demethyl-N-isopropyl-erythromycin-A-spiroacetal compounds corresponding to formula I I having gastrointestinally effective motilin-agonistic properties and the preparation thereof.

公开(公告)号：AT155478T

公开(公告)日：1997-08-15

申请号：AT92122011

申请日：1992-12-24

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  PREUSCHOFF ULF ,  EECKHOUT CHRISTIAN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/14 ,  A61P43/00 ,  C07H17/08

Abstract: Ring-contracted N-demethyl-N-isopropylerythromycin A derivatives with gastrointestinally effective motilin-agonistic properties and the preparation thereof are described.

公开(公告)号：UA84896C2

公开(公告)日：2008-12-10

申请号：UAA200607374

申请日：2004-12-09

Applicant: SOLVAY PHARM GMBH

Inventor： MENTZEL MATTHIAS ,  REICHE DANIA B ,  BRUCKNER REINHARD ,  DAVID SAMUEL ,  VAN STEEN BARTHOLOMEUS J ,  SCHON UWE ,  JASSERAND DANIEL ,  PREUSCHOFF ULF

IPC: C07D471/00 ,  A61K31/438 ,  A61K31/4747 ,  A61P9/06 ,  A61P9/12 ,  A61P29/00 ,  C07D221/00 ,  C07D233/00 ,  C07D471/10 ,  C07D487/08

Abstract: Изобретениекасаетсягруппыпроизводныхгидронопола, которыеявляютсяагонистамичеловеческихрецепторов ORL1 (ноцицептина).Изобретениетакжекасаетсяспособовполученияэтихсоединений, фармацевтическихкомпозиций, которыесодержатфармакологическиактивноеколичество, покрайнеймере, одногоизэтихновыхпроизводныхгидронополакакдействующеговещества, атакжепримененияэтихфармацевтическихкомпозицийдлялечениярасстройств, связанныхс рецепторами ORL1.Изобретениекасаетсясоединенийобщейформулы (1),гдерадикалыимеютзначения, которыеприведеныв описании.

公开(公告)号：NO324867B1

公开(公告)日：2007-12-17

申请号：NO20024351

申请日：2002-09-12

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  BRUECKNER REINHARD ,  ANTEL JOCHEN ,  JASSERAND DANIEL ,  PREUSCHOFF ULF ,  SANN HOLGER ,  REICHE DANIA ,  EECKHOUT CHRISTIAN

IPC: C07D295/12 ,  A61K31/341 ,  A61K31/381 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/08 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092 ,  C07D307/52 ,  C07D333/20 ,  C07D407/04 ,  C07D407/06 ,  C07D409/06

Abstract: 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives (I) are new. Also new are 1-unsubstituted analog intermediates (II). 1-(1-(Hetero)aryl)-1-(polyhydroxyalkyl)-methyl)-4-(4-(N-methylbenzamid o)-3-phenylbutyl)-piperazine derivatives of formula (I) and their acid addition salts are new. A = naphthyl, phenyl (optionally substituted by OH), mono- or bi-cyclic heteroaryl or 3-6C alkenyl (optionally substituted by phenyl); Q = (CHOR1)k-(CHOR2)l-(CHOR3)m-(CHOR4)n-CH2OR5 ; R1-R5 = H or lower alkanoyl, or two of R1-R5 = CO, CS or CH2 (optionally substituted by lower alkyl or 4-5C alkylene), completing a 5- or 6-membered ring; k, l, m, n = 0 or 1, and R6, R7 = H or halo. Independent claims are also included for: (1) the preparation of (I), and (2) new piperazine derivative intermediates of formula (II).

公开(公告)号：CA2219311C

公开(公告)日：2007-09-04

申请号：CA2219311

申请日：1997-10-24

Applicant: SOLVAY PHARM GMBH

Inventor： EECKHOUT CHRISTIAN ,  FINNER EMIL ,  HOELTJE DAGMAR ,  PREUSCHOFF ULF

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/06 ,  A61P43/00

Abstract: Ring-contracted N-demethyl-N-isopropyl-erythromycin-A- spiroacetal compounds corresponding to formula I having gastrointestinally effective motilin-agonistic properties and the preparation thereof.