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公开(公告)号：CA2948104A1
公开(公告)日：2010-05-14
申请号：CA2948104
申请日：2009-11-06
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , MILLER MARK T , MCCARTNEY JASON , VAN GOOR FREDRICK , NUMA MEHDI MICHEL DJAMEL , ZHOU JINGLAN , BEAR BRIAN
IPC: C07D405/12 , A61K31/404
Abstract: Compounds and pharmaceutically acceptable compositions thereof are disclosed, which may be used as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR").
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公开(公告)号：CA2742821A1
公开(公告)日：2010-05-14
申请号：CA2742821
申请日：2008-11-12
Applicant: VERTEX PHARMA
Inventor： RUAH SARA HADIDA S , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , MILLER MARK T , MCCARTNEY JASON , ZHOU JINGLAN , BEAR BRIAN , NUMA MEHDI MICHEL DJAMEL
IPC: C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：ZA200803887B
公开(公告)日：2009-12-30
申请号：ZA200803887
申请日：2006-11-08
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC: A61K20100101 , A61P20100101 , C07D20100101
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention..
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公开(公告)号：CA2718310A1
公开(公告)日：2009-10-08
申请号：CA2718310
申请日：2009-03-25
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER
IPC: C07D213/75 , A61K31/44 , A61K31/4427 , A61P43/00 , C07D405/12 , C07D405/14 , C07D413/14
Abstract: The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, of formula (I), and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：CA3039943A1
公开(公告)日：2009-09-03
申请号：CA3039943
申请日：2009-02-25
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN
IPC: C07D405/12 , A61K31/495 , A61K31/497 , C07D241/20
Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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Patent Agency Ranking
公开(公告)号：AU2008322616A1
公开(公告)日：2009-05-22
申请号：AU2008322616
申请日：2008-11-14
Applicant: VERTEX PHARMA
Inventor： RUAH SARA HADIDA , BEAR BRIAN , GROOTENHUIS PETER D J , ZHOU JINGLAN , MILLER MARK
IPC: C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
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公开(公告)号：CA2699382A1
公开(公告)日：2009-03-19
申请号：CA2699382
申请日：2008-09-15
Applicant: VERTEX PHARMA
Inventor： BINCH HAYLEY , GROOTENHUIS PETER D J , HADIDA RUAH SARA S , ZHOU JINGLAN , HAZLEWOOD ANNA , FANNING LEV T D
IPC: C07D471/04 , A61K31/4375 , A61P3/00
Abstract: The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：AU2006331614A1
公开(公告)日：2007-07-05
申请号：AU2006331614
申请日：2006-12-21
Applicant: VERTEX PHARMA
Inventor： ARUMUGAM VIJAYALAKSMI , BINCH HAYLEY , RUAH SARA HADIDA , GUTIERREZ COREY , ZHOU JINGLAN , GROOTENHUIS PETER D J , HAZLEWOOD ANNA
IPC: C07F9/60 , A61K31/47 , A61K31/661 , A61P29/00 , A61P31/00 , C07D215/56
Abstract: The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modulators, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：CA2627358A1
公开(公告)日：2007-05-18
申请号：CA2627358
申请日：2006-11-08
Applicant: VERTEX PHARMA
Inventor： HAMILTON MATTHEW , HADIDA RUAH SARA , MILLER MARK , GROOTENHUIS PETER D J , ZHOU JINGLAN , MCCARTHY JASON , BEAR BRIAN
IPC: C07D405/12 , A61K31/4418 , A61K31/5585 , A61P11/00 , C07D213/75 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention..
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公开(公告)号：MX2007000095A
公开(公告)日：2007-03-21
申请号：MX2007000095
申请日：2005-06-24
Applicant: VERTEX PHARMA
Inventor： GROOTENHUIS PETER D J , SARAH S HADIDA RUAH , HAZLEWOOD ANNA R , GOOR FREDERICK F VAN , SINGH ASHVANI K , ZHOU JINGLAN , MCCARTNEY JASON
IPC: C07D215/00
Abstract: La presente invencion se relaciona con moduladores de transportadores con casete de union con ATP ("ABC") o fragmentos de los mismos, incluyendo un Regulador de Conductancia Transmembrana de Fibrosis Quistica, las composiciones de los mismos, y los metodos de los mismos. La presente invencion tambien se relaciona con los metodos para tratar las enfermedades producidas por el transportador con ABC utilizando estos moduladores.
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