公开(公告)号：WO2007021982A3

公开(公告)日：2007-05-03

申请号：PCT/US2006031457

申请日：2006-08-11

Applicant: VERTEX PHARMA ,  HADIDA RUAH SARA ,  VANGOOR FREDERICK F ,  MILLER MARK T ,  MCCARTNEY JASON ,  ARUMUGAM VIJAYALAKSMI

Inventor： HADIDA RUAH SARA ,  VANGOOR FREDERICK F ,  MILLER MARK T ,  MCCARTNEY JASON ,  ARUMUGAM VIJAYALAKSMI

IPC: C07D417/14 ,  A61K31/427 ,  A61P25/16

CPC classification number: C07D417/14 ,  A61K31/427

Abstract: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.

Abstract translation: 本发明涉及囊性纤维化跨膜电导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗CFTR介导的疾病的方法。

公开(公告)号：WO2014120820A1

公开(公告)日：2014-08-07

申请号：PCT/US2014013667

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN LULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D213/79 ,  A61K31/44 ,  A61P29/00 ,  C07C235/64

CPC classification number: A61K31/44 ,  A61K31/192 ,  C07C235/64 ,  C07D213/79

Abstract: The invention relates to amide compounds of formula I and For pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I), (I') The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract translation: 本发明涉及式I的酰胺化合物及其药学上可接受的盐，其可用作钠通道的抑制剂：（I），（I'）本发明还提供包含本发明化合物的药学上可接受的组合物和使用组合物的方法 治疗各种疾病，包括疼痛。

公开(公告)号：WO2014120808A8

公开(公告)日：2015-09-11

申请号：PCT/US2014013652

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D213/75 ,  A61K31/44 ,  A61P29/00 ,  C07D401/12

CPC classification number: C07D213/75 ,  A61K31/4412 ,  C07D401/12 ,  C07D405/12

Abstract: The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: I, I', The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract translation: 本发明涉及用作钠通道抑制剂的式I和I'或其药学上可接受的盐的吡啶酮酰胺化合物：本发明还提供了包含本发明化合物的药学上可接受的组合物和使用该组合物的方法 用于治疗各种疾病，包括疼痛。

公开(公告)号：WO2014120815A1

公开(公告)日：2014-08-07

申请号：PCT/US2014013662

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D403/12 ,  A61K31/465 ,  A61K31/4709 ,  A61K31/498 ,  A61P25/00 ,  A61P29/00 ,  C07D215/54 ,  C07D241/44 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07D215/54 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  C07D241/44 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: formula (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Abstract translation: 本发明涉及可用作钠通道抑制剂的式（I）化合物或其药学上可接受的盐：式（I）。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括疼痛）的方法。

公开(公告)号：WO2007075901A2

公开(公告)日：2007-07-05

申请号：PCT/US2006048810

申请日：2006-12-21

Applicant: VERTEX PHARMA ,  GROOTENHUIS PETER D J ,  HADIDA RUAH SARA ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY ,  BINCH HAYLEY

Inventor： GROOTENHUIS PETER D J ,  HADIDA RUAH SARA ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY ,  BINCH HAYLEY

CPC classification number: G01N33/502 ,  A61K31/47 ,  A61K31/675 ,  A61K45/06 ,  C07D215/56 ,  C07F9/60 ,  C12Q1/34 ,  G01N33/6872 ,  G01N2333/914 ,  G01N2500/10 ,  G01N2500/20

Abstract: The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modulators, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ABC转运蛋白调节剂的前体药物，特别是CFTR调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2007075895A2

公开(公告)日：2007-07-05

申请号：PCT/US2006048802

申请日：2006-12-21

Applicant: VERTEX PHARMA ,  WILSON DEAN ,  FANNING LEV T D ,  SHETH URVI ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  ZIMMERMANN NICOLE ,  KNOLL TARA ,  WHITNEY TARA ,  KAWATKAR AARTI ,  LEHSTEN DANIELLE ,  STAMOS DEAN ,  ZHOU JINGLAN ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY

Inventor： WILSON DEAN ,  FANNING LEV T D ,  SHETH URVI ,  MARTINBOROUGH ESTHER ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  ZIMMERMANN NICOLE ,  KNOLL TARA ,  WHITNEY TARA ,  KAWATKAR AARTI ,  LEHSTEN DANIELLE ,  STAMOS DEAN ,  ZHOU JINGLAN ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY

CPC classification number: C07D417/12 ,  C07D239/42 ,  C07D401/12 ,  C07D405/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/10

Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract translation: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

公开(公告)号：AU2021358063A9

公开(公告)日：2025-03-13

申请号：AU2021358063

申请日：2021-10-06

Applicant: VERTEX PHARMA

Inventor： MCCARTNEY JASON ,  ABELA ALEXANDER RUSSELL ,  ABRAHAM SUNNY ,  ANDERSON COREY DON ,  ARUMUGAM VIJAYALAKSMI ,  CHAU JACLYN ,  CLEMENS JEREMY ,  CLEVELAND THOMAS ,  COON TIMOTHY RICHARD ,  DWIGHT TIMOTHY A ,  FANNING LEV TYLER DEWEY ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER (DECEASED) ,  GULEVICH ANTON V ,  HADIDA RUAH SARA SABINA ,  ISHIHARA YOSHIHIRO ,  KHATUYA HARIPADA ,  KRENITSKY PAUL ,  MELILLO VITO ,  MILLER MARK THOMAS ,  PARASELLI PRASUNA ,  PIERRE FABRICE ,  SILINA ALINA ,  TRAN JOE A ,  UY JOHNNY ,  VALDEZ LINO ,  ZHOU JINGLAN

IPC: C07D515/04 ,  A61K31/519 ,  A61P43/00

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

公开(公告)号：MA54649A

公开(公告)日：2022-04-27

申请号：MA54649

申请日：2015-10-06

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  BEAR BRIAN RICHARD ,  BINCH HAYLEY MARIE ,  CLEMENS JEREMY J ,  CLEVELAND THOMAS ,  CONROY ERICA ,  COON TIMOTHY RICHARD ,  FRIEMAN BRYAN A ,  GROOTENHUIS PETER DIEDERIK JAN ,  GROSS RAYMOND STANLEY ,  HADIDA-RUAH SARA SABINA ,  JOSHI PRAMOD VIRUPAX ,  KHATUYA HARIPADA ,  KRENITSKY PAUL JOHN ,  LIN CHUN-CHIEH ,  MARELIUS GULIN ERDOGAN ,  MCCARTNEY JASON ,  MELILLO VITO ,  MILLER MARK THOMAS ,  NICHOLLS GEORGIA MCGAUGHEY ,  PIERRE FABRICE JEAN DENIS ,  SILINA ALINA ,  TERMIN ANDREAS P ,  UY JOHNNY ,  ZHOU JINGLAN

IPC: A01N41/06 ,  A61K31/18 ,  C07D209/18 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D401/04 ,  C07D403/10 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14

公开(公告)号：ECSP21077043A

公开(公告)日：2021-12-30

申请号：ECDI202177043

申请日：2021-10-20

Applicant: VERTEX PHARMA

Inventor： ANDERSON COREY DON ,  VITO MELILLO ,  SILINA ALINA ,  HADIDA RUAH SARA SABINA ,  KRENITSKY PAUL ,  CLEMENS JEREMY ,  ABELA ALEXANDER RUSSELL ,  MCCARTNEY JASON ,  MILLER MARK THOMAS ,  GROOTENHUIS PETER (FALLECIDO) ,  ABRAHAM SUNNY ,  CLEVELAND THOMAS ,  UY JOHNNY ,  ISHIHARA YOSHIHIRO ,  ZHOU JINGLAN ,  CHAU JACLYN ,  DWIGHT TIMOTHY A ,  ARUMUGAM VIJAYALAKSMI ,  FRIEMAN BRYAN A

IPC: A61P11/00 ,  C07D239/69 ,  C07D515/08

Abstract: Se describen el compuesto I, derivados deuterados y sales farmacéuticamente aceptables de cualquiera de los precedentes. También se describen métodos para tratar la fibrosis cística utilizando dichos compuestos. (LA FORMULA SE APRECIA EN LA DESCRIPCION TECNICA)

公开(公告)号：CA2898653C

公开(公告)日：2021-09-28

申请号：CA2898653

申请日：2014-01-29

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA SABINA ,  ANDERSON COREY ,  ARUMUGAM VIJAYALAKSMI ,  ASGIAN IULIANA LUCI ,  BEAR BRIAN RICHARD ,  TERMIN ANDREAS P ,  JOHNSON JAMES PHILIP

IPC: C07D213/79 ,  A61K31/44 ,  A61P29/00 ,  C07C235/64

Abstract: The invention relates to amide compounds of formulae I and I': and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.