公开(公告)号：WO2007044560A3

公开(公告)日：2007-06-14

申请号：PCT/US2006039220

申请日：2006-10-06

Applicant: VERTEX PHARMA ,  HADIDA RUAH SARA ,  HAZLEWOOD ANNA

Inventor： HADIDA RUAH SARA ,  HAZLEWOOD ANNA

IPC: A61K31/404 ,  A61P3/06 ,  A61P3/10 ,  A61P5/14 ,  A61P5/18 ,  A61P7/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/16 ,  A61P35/00 ,  A61P43/00

CPC classification number: C07D209/12 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  C07D209/30 ,  C07D209/42 ,  Y10S514/851

Abstract: The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP-B包装盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2009036412A8

公开(公告)日：2013-08-01

申请号：PCT/US2008076376

申请日：2008-09-15

Applicant: VERTEX PHARMA ,  BINCH HAYLEY ,  GROOTENHUIS PETER D J ,  HADIDA RUAH SARA S ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  FANNING LEV T D

Inventor： BINCH HAYLEY ,  GROOTENHUIS PETER D J ,  HADIDA RUAH SARA S ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  FANNING LEV T D

IPC: C07D471/04 ,  A61K31/4375 ,  A61P3/00

CPC classification number: A61K31/4375 ,  C07D471/04

Abstract: The present invention relates to modulators of ATP-B inding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ATP-B包装盒（'ABC'）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：WO2007075901A2

公开(公告)日：2007-07-05

申请号：PCT/US2006048810

申请日：2006-12-21

Applicant: VERTEX PHARMA ,  GROOTENHUIS PETER D J ,  HADIDA RUAH SARA ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY ,  BINCH HAYLEY

Inventor： GROOTENHUIS PETER D J ,  HADIDA RUAH SARA ,  ZHOU JINGLAN ,  HAZLEWOOD ANNA ,  ARUMUGAM VIJAYALAKSMI ,  GUTIERREZ COREY ,  BINCH HAYLEY

CPC classification number: G01N33/502 ,  A61K31/47 ,  A61K31/675 ,  A61K45/06 ,  C07D215/56 ,  C07F9/60 ,  C12Q1/34 ,  G01N33/6872 ,  G01N2333/914 ,  G01N2500/10 ,  G01N2500/20

Abstract: The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modulators, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract translation: 本发明涉及ABC转运蛋白调节剂的前体药物，特别是CFTR调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。

公开(公告)号：AU2006302371A1

公开(公告)日：2007-04-19

申请号：AU2006302371

申请日：2006-10-06

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA ,  HAZLEWOOD ANNA

IPC: A61K31/404 ,  A61P3/06 ,  A61P3/10 ,  A61P5/14 ,  A61P5/18 ,  A61P7/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/16 ,  A61P35/00 ,  A61P43/00

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：NO20082082L

公开(公告)日：2008-06-25

申请号：NO20082082

申请日：2008-05-05

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA ,  HAZLEWOOD ANNA

IPC: A61K31/404 ,  A61P3/06 ,  A61P3/10

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：CA2634113A1

公开(公告)日：2007-07-05

申请号：CA2634113

申请日：2006-12-21

Applicant: VERTEX PHARMA

Inventor： GUTIERREZ COREY ,  BINCH HAYLEY ,  ARUMUGAM VIJAYALAKSMI ,  HAZLEWOOD ANNA ,  ZHOU JINGLAN ,  HADIDA RUAH SARA ,  GROOTENHUIS PETER D J

IPC: C07F9/60 ,  A61K31/47 ,  A61K31/661 ,  A61P29/00 ,  A61P31/00 ,  C07D215/56

公开(公告)号：CA2624683A1

公开(公告)日：2007-04-19

申请号：CA2624683

申请日：2006-10-06

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  HAZLEWOOD ANNA

IPC: A61K31/404 ,  A61P3/06 ,  A61P3/10 ,  A61P5/14 ,  A61P5/18 ,  A61P7/00 ,  A61P11/00 ,  A61P25/00 ,  A61P25/16 ,  A61P35/00 ,  A61P43/00

Abstract: The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2008298545B2

公开(公告)日：2013-12-12

申请号：AU2008298545

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： HAZLEWOOD ANNA ,  HADIDA RUAH SARA S ,  BINCH HAYLEY ,  FANNING LEV T D ,  GROOTENHUIS PETER D J ,  ZHOU JINGLAN

IPC: C07D471/04 ,  A61K31/4375 ,  A61P3/00

Abstract: The present invention relates to modulators of ATP-B inding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AT533749T

公开(公告)日：2011-12-15

申请号：AT06770825

申请日：2006-05-22

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  SINGH ASHVANI ,  GROOTENHUIS PETER ,  VAN GOOR FREDRICK ,  CLEVELAND THOMAS ,  HAZLEWOOD ANNA

IPC: C07D239/42

Abstract: 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2008298545A1

公开(公告)日：2009-03-19

申请号：AU2008298545

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  ZHOU JINGLAN ,  BINCH HAYLEY ,  HAZLEWOOD ANNA ,  FANNING LEV T D ,  GROOTENHUIS PETER D J

IPC: C07D471/04 ,  A61K31/4375 ,  A61P3/00

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.