公开(公告)号：US09513225B2

公开(公告)日：2016-12-06

申请号：US14378710

申请日：2013-02-11

Applicant: BAR ILAN UNIVERSITY

Inventor： Zeev Zalevsky ,  Yair Hammer

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01N2201/06113 ,  G01N2201/126

Abstract: The present disclosure provides systems and methods for improving the resolution of a spectrometer configured to provide a frequency spectrum of a radiation incoming from a sample. The system comprises an optical medium configured so that the radiation incoming from the sample be transferred through the optical medium, the optical medium having a predetermined tunable spectral transmission curve; an operating unit connectable to the optical medium and configured to operate the optical medium so as to shift the spectral transmission curve of the optical medium over a predetermined spectral range; and a processing unit connectable to the spectrometer and configured to process a set of shifted frequency spectra provided by the spectrometer and obtainable by transferring the radiation incoming from the sample through the optical medium while shifting the spectral transmission curve of the optical medium so as to obtain a super resolved frequency spectrum of improved spectral resolution.

Abstract translation: 本公开提供了用于改进配置为提供从样品进入的辐射的频谱的光谱仪的分辨率的系统和方法。 该系统包括光学介质，其被配置为使得从样品入射的辐射通过光学介质传输，光学介质具有预定的可调谐光谱透射曲线; 操作单元，其可连接到所述光学介质并且被配置为操作所述光学介质，以便使光学介质的光谱传输曲线在预定的光谱范围内移动; 以及处理单元，其可连接到所述光谱仪并且被配置为处理由所述光谱仪提供的一组移动的频谱，并且可以通过在移动所述光学介质的光谱透射曲线的同时转移通过所述光学介质从所述样品入射的辐射而获得， 一种改进的光谱分辨率的超解析频谱。

公开(公告)号：US09217695B2

公开(公告)日：2015-12-22

申请号：US12785314

申请日：2010-05-21

Applicant: James Winkelman ,  Milenko Tanasijevic ,  David Zahniser

Inventor： James Winkelman ,  Milenko Tanasijevic ,  David Zahniser

IPC: C12M1/34 ,  G06K9/00 ,  G01N1/28 ,  G01N35/00 ,  G01N1/31 ,  G01N15/14

CPC classification number: G01N15/1475 ,  G01N1/2813 ,  G01N1/312 ,  G01N21/255 ,  G01N33/49 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/1016 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2035/00138 ,  G01N2035/00465 ,  G01N2035/0091 ,  G01N2201/062 ,  G01N2201/126 ,  G01N2333/805 ,  G06K9/4652 ,  G06K9/6267 ,  G06T7/0012 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/265

Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.

Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

公开(公告)号：US20150355099A1

公开(公告)日：2015-12-10

申请号：US14297699

申请日：2014-06-06

Applicant: Hamilton Sundstrand Corporation

Inventor： Russell Fordyce ,  Ryan Chase

IPC: G01N21/88

CPC classification number: G01N21/88 ,  G01M5/0033 ,  G01N21/8806 ,  G01N21/8851 ,  G01N29/041 ,  G01N29/2418 ,  G01N2021/8427 ,  G01N2021/8924 ,  G01N2021/9516 ,  G01N2201/117 ,  G01N2201/126

Abstract: A scratch verification method and apparatus for detecting and analyzing defects in a surface, the apparatus include a detection device with a plurality of emission sources and a plurality of sensors. A processor is connected to the detection device and is configured to apply one or more sets of criteria to one or more corresponding target areas of a surface. The processor is further configured to differentiate between data from the one or more target areas.

Abstract translation: 一种用于检测和分析表面缺陷的划痕验证方法和装置，该装置包括具有多个发射源和多个传感器的检测装置。 处理器连接到检测装置，并且被配置为将一组或多组标准应用于表面的一个或多个对应的目标区域。 处理器还被配置为区分来自一个或多个目标区域的数据。

公开(公告)号：US20150002848A1

公开(公告)日：2015-01-01

申请号：US14372093

申请日：2013-01-15

Applicant: FEMTOLASERS PRODUCTIONS GMBH

Inventor： Gabriel-Florin Tempea

IPC: G01J3/45 ,  G01N21/25

CPC classification number: G01J3/45 ,  E01H5/045 ,  G01J3/4531 ,  G01J2003/283 ,  G01J2003/451 ,  G01J2003/4538 ,  G01M11/005 ,  G01N21/25 ,  G01N21/45 ,  G01N2021/4126 ,  G01N2201/126 ,  G02B1/115 ,  G02B5/0825

Abstract: Method and device for optical inspection of a sample using spectral interferometry, wherein a beam (2″) emitted by a radiation source (1) is directed onto the sample (5) and a reference beam (2′) is directed onto a reference sample (4), and the spectral interference of both beams after being reflected on the samples or after passing the samples is recorded by means of a spectrograph (6); the interferogram I(ω) thus obtained is numerically derived with respect to the angular frequency ω. For the function I′(ω) thus obtained the zeros ωi are calculated numerically as solutions to the equation I′(ω)=0 and the frequency-dependent group delay τ(ω) is then calculated from the zeros ωi according to the equation τ(ωn)=π/(ωi+1−ωi), wherein i=1, 2 . . . and ωn=(ωi+1+ωi)2.

Abstract translation: 用于使用光谱干涉测量法对样品进行光学检查的方法和装置，其中由辐射源（1）发射的光束（2“）被引导到样品（5）上，并且参考光束（2'）被引导到参考样品 （4），并且两个光束在样品上反射之后或在通过样品之后的光谱干涉通过光谱仪（6）记录; 这样获得的干涉图I（ω）相对于角频率ω被数值地导出。 对于由此获得的函数I'（ω），零数值被计算为等式I'（ω）= 0的解，并且然后根据等式从零的ωi计算频率相关组延迟τ（ω） τ（ωn）=＆pgr; /（ωi+ 1-ωi），其中i = 1,2。 。 。 和ωn=（ωi+ 1 +ωi）2。

公开(公告)号：US08237786B2

公开(公告)日：2012-08-07

申请号：US12751816

申请日：2010-03-31

Applicant: Gaudenz Danuser ,  Paul C. Goodwin

Inventor： Gaudenz Danuser ,  Paul C. Goodwin

IPC: H04N9/47 ,  H04N13/04

CPC classification number: G01N21/6428 ,  G01N21/636 ,  G01N21/6458 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2201/126 ,  G02B21/365 ,  G02B21/367 ,  G06T3/4053

Abstract: Embodiments of the present invention are directed to imaging technologies, and, in particular, to an imaging system that detects relatively weak signals, over time, and that uses the detected signals to determine the positions of signal emitters. Particular embodiments of the present invention are directed to methods and systems for imaging fluorophore-labeled samples in order to produce images of the sample at resolutions significantly greater than the diffraction-limited resolution associated with optical microscopy. Embodiments of the present invention employ overlapping-emitter-image disambiguation to allow data to be collected from densely arranged emitters, which significantly decreases the data-collection time for producing intermediate images as well as the number of intermediate images needed to computationally construct high-resolution final images. Additional embodiments of the present invention employ hierarchical image-processing techniques to further resolve and interpret disambiguated images.

Abstract translation: 本发明的实施例涉及成像技术，特别涉及一种随时间检测相对较弱信号的成像系统，并且使用所检测的信号来确定信号发射器的位置。 本发明的具体实施方案涉及用于成像荧光团标记的样品的方法和系统，以便以明显大于与光学显微镜相关联的衍射限制分辨率的分辨率产生样品的图像。 本发明的实施例采用重叠 - 发射 - 图像消歧以允许从密集布置的发射器收集数据，这显着减少用于产生中间图像的数据收集时间以及计算构建高分辨率所需的中间图像的数量 最终图像。 本发明的另外的实施例采用分层图像处理技术来进一步解析和解释消歧图像。

公开(公告)号：US20110291027A1

公开(公告)日：2011-12-01

申请号：US13102551

申请日：2011-05-06

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/64 ,  G01J1/58

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

公开(公告)号：US20100284602A1

公开(公告)日：2010-11-11

申请号：US12785314

申请日：2010-05-21

Applicant: James WINKELMAN ,  Milenko TANASIJEVIC ,  David ZAHNISER

Inventor： James WINKELMAN ,  Milenko TANASIJEVIC ,  David ZAHNISER

IPC: G06K9/00

CPC classification number: G01N15/1475 ,  G01N1/2813 ,  G01N1/312 ,  G01N21/255 ,  G01N33/49 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/1016 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1006 ,  G01N2015/1472 ,  G01N2015/1486 ,  G01N2015/1497 ,  G01N2035/00138 ,  G01N2035/00465 ,  G01N2035/0091 ,  G01N2201/062 ,  G01N2201/126 ,  G01N2333/805 ,  G06K9/4652 ,  G06K9/6267 ,  G06T7/0012 ,  H04N5/2256 ,  H04N5/23293 ,  H04N5/265

Abstract: Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.

Abstract translation: 公开了分析体液如血液和骨髓的系统和方法。 系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。 本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

公开(公告)号：US07626704B2

公开(公告)日：2009-12-01

申请号：US11978138

申请日：2007-10-26

Applicant: Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

Inventor： Paul Lundquist ,  Denis Zaccarin ,  Yves Lacroix ,  Mark Maxham ,  Mathieu Foquet ,  Stephen Turner

IPC: G01N21/25

CPC classification number: G01N21/6452 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2803 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6417 ,  G01N2201/126

Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

Abstract translation: 用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。 系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

公开(公告)号：US5866349A

公开(公告)日：1999-02-02

申请号：US768255

申请日：1991-10-16

Applicant: Jan Evert Lilja ,  Sven-Erik Lennart Nilsson

Inventor： Jan Evert Lilja ,  Sven-Erik Lennart Nilsson

IPC: C12M1/34 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/533 ,  C12Q1/54 ,  G01N15/00 ,  G01N21/03 ,  G01N21/31 ,  G01N21/35 ,  G01N21/78 ,  G01N33/48 ,  G01N33/493

CPC classification number: C12Q1/54 ,  G01N21/03 ,  G01N21/314 ,  G01N2015/0069 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/3181 ,  G01N21/78 ,  G01N2201/1222 ,  G01N2201/126 ,  G01N33/493

Abstract: A sample of whole blood is contacted with a reagent which by chemical reaction with glucose in the sample brings about a detectable dye concentration change (10) the size of which is determined as a measure of the glucose content of the sample. The sample is initially introduced undiluted in a microcuvette having at least one cavity for receiving the sample. The cavity is internally pretreated with the reagent in dry form, and the chemical reaction takes place in the cavity. Active components of the reagent comprise at least a hemolyzing agent for exposing glucose contained in the blood cells of the sample for allowing total glucose determination, and agents taking part in the chemical reaction and ensuring that the dye concentration change (10) takes place at least in a wavelength range (14) outside the absorption range (12) of the blood hemoglobin. An absorption measurement is performed in said wavelength range directly on the sample in the cuvette. A pretreated disposable cuvette with such a reagent and a photometer are also described.

Abstract translation: PCT No.PCT / SE90 / 00273 Sec。 371日期1991年10月16日 102（e）日期1991年10月16日PCT 1990年4月24日PCT PCT。 WO90 / 12890 PCT出版物 日期1990年11月1日全血样品与试剂接触，该试剂通过与样品中的葡萄糖的化学反应产生可检测的染料浓度变化（10），其大小被确定为样品的葡萄糖含量的量度 。 样品最初在具有至少一个用于接收样品的空腔的微量储存器中未稀释地引入。 空腔内部用干燥形式的预处理，化学反应发生在空腔中。 试剂的活性组分至少包含用于暴露样品血细胞中所含的葡萄糖的溶血剂，以允许总葡萄糖测定，以及参与化学反应的试剂，并确保染料浓度变化（10）至少发生 在血红蛋白的吸收范围（12）之外的波长范围（14）中。 在比色皿中的样品上直接在所述波长范围内进行吸收测量。 还描述了具有这种试剂和光度计的预处理的一次性比色杯。

公开(公告)号：US5118183A

公开(公告)日：1992-06-02

申请号：US480331

申请日：1990-02-13

Applicant: Mark A. Cargill ,  Bernard J. Berg ,  Steven H. Peterson ,  Timothy R. Friend ,  Thomas J. Boes

Inventor： Mark A. Cargill ,  Bernard J. Berg ,  Steven H. Peterson ,  Timothy R. Friend ,  Thomas J. Boes

IPC: G01J3/10 ,  G01J3/51 ,  G01N21/01 ,  G01N21/59 ,  G01N21/86 ,  G01N35/00

CPC classification number: G01J3/51 ,  G01J3/10 ,  G01J3/524 ,  G01N21/86 ,  G01J3/513 ,  G01N2021/0162 ,  G01N2021/1734 ,  G01N21/4738 ,  G01N21/59 ,  G01N21/8483 ,  G01N2201/0694 ,  G01N2201/126 ,  G01N35/00029

Abstract: A densitometer apparatus (410) is disclosed and is adapted to provide color density measurements of object samples. The densitometer apparatus (410) comprises a source light (580) for projecting light toward an object sample comprising a control strip (588, 620). A reflection optics assembly (576) is adapted to measure light density reflected from the object sample when the object sample is in the form of a paper control strip. A transmission optics assembly (618) is adapted to measure transmission density of light rays projected through the object sample when the object sample is in the form of a film control strip. A motor assembly (426) operating with a drive wheel assembly (434) and idler wheel assembly (440) automatically moves the object sample (588, 620) through the apparatus (410) adjacent the source light (580). A pair of guides (468, 470) are selectively adjustable by the operator to control movement of the object sample (588, 620) through the apparatus (410). In response to input from a key switch assembly (492) activatable by the operator, the apparatus (410) is adapted to perform various color density measurement and calibration functions, and display appropriate information to the operator through the use of a visual display (490).

Abstract translation: 公开了一种密度计装置（410），并且适用于提供对象样品的颜色浓度测量。 密度计装置（410）包括用于向包括控制条（588,620）的物体样品投射光的源光（580）。 反射光学组件（576）适用于当对象样本呈纸控制条的形式时，测量从对象样本反射的光密度。 传输光学组件（618）适于测量当对象样本呈胶卷控制条形式时通过对象样品投射的光线的透射密度。 用驱动轮组件（434）和惰轮组件（440）操作的马达组件（426）自动地使物体样品（588,620）通过邻近源光（580）的设备（410）移动。 一对引导件（468,470）可由操作者选择性调节，以控制物体样品（588,620）通过设备（410）的移动。 响应于由操作员激活的钥匙开关组件（492）的输入，装置（410）适于执行各种颜色浓度测量和校准功能，并且通过使用视觉显示器（490）向操作者显示适当的信息 ）。