公开(公告)号：WO2011103020A1

公开(公告)日：2011-08-25

申请号：PCT/US2011/024325

申请日：2011-02-10

Applicant: CARDIAC PACEMAKERS, INC. ,  BECK, Kenneth C. ,  BAKER, Lemont ,  LIU, Kassity Yefei

Inventor： BECK, Kenneth C. ,  BAKER, Lemont ,  LIU, Kassity Yefei

IPC: G06F19/00 ,  A61B5/04

CPC classification number: A61B5/1118 ,  A61B5/0245 ,  A61B5/0816 ,  G06F19/00 ,  G16H50/50

Abstract: A physiological response to activity (PRA) during a subject's activities of daily living (ADL) can be used, such as to generate useful diagnostic information about the subject. This can involve using a template, such as an impulse response template. The technique can be used with an implantable or other ambulatory medical monitoring or therapy device, such as a cardiac function management device, or with a local or remote external interface device.

Abstract translation: 可以使用在受试者的日常生活活动（ADL）期间对活动的生理反应（PRA），例如产生有关该受试者的有用的诊断信息。 这可以涉及使用模板，例如脉冲响应模板。 该技术可以与可植入或其他动态医疗监测或治疗装置（例如心脏功能管理装置）或本地或远程外部接口装置一起使用。

公开(公告)号：WO2010042790A3

公开(公告)日：2010-04-15

申请号：PCT/US2009/060118

申请日：2009-10-09

Applicant: CARDIAC PACEMAKERS, INC. ,  ZHANG, Yi ,  STAHMANN, Jeffrey E. ,  SIEJKO, Krzysztof Z. ,  WARIAR, Ramesh ,  THOMPSON, Julie A. ,  HATLESTAD, John D. ,  BECK, Kenneth C.

Inventor： ZHANG, Yi ,  STAHMANN, Jeffrey E. ,  SIEJKO, Krzysztof Z. ,  WARIAR, Ramesh ,  THOMPSON, Julie A. ,  HATLESTAD, John D. ,  BECK, Kenneth C.

IPC: A61B5/02 ,  A61B5/00 ,  A61N1/39 ,  A61B5/085 ,  A61B5/0452 ,  A61B5/12 ,  A61B7/04 ,  A61B5/029 ,  A61B5/0215

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

公开(公告)号：WO2010042790A2

公开(公告)日：2010-04-15

申请号：PCT/US2009060118

申请日：2009-10-09

Applicant: CARDIAC PACEMAKERS INC ,  ZHANG YI ,  STAHMANN JEFFREY E ,  SIEJKO KRZYSZTOF Z ,  WARIAR RAMESH ,  THOMPSON JULIE A ,  HATLESTAD JOHN D ,  BECK KENNETH C

Inventor： ZHANG YI ,  STAHMANN JEFFREY E ,  SIEJKO KRZYSZTOF Z ,  WARIAR RAMESH ,  THOMPSON JULIE A ,  HATLESTAD JOHN D ,  BECK KENNETH C

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0452 ,  A61B5/085 ,  A61B5/12 ,  A61B7/04 ,  A61N1/39

CPC classification number: A61B5/02055 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/029 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/085 ,  A61B5/1118 ,  A61B5/121 ,  A61B5/14542 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36585

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

Abstract translation: 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。

公开(公告)号：WO2012087696A3

公开(公告)日：2012-06-28

申请号：PCT/US2011/064811

申请日：2011-12-14

Applicant: CARDIAC PACEMAKERS, INC. ,  AVERINA, Viktoria A. ,  HATLESTAD, John D. ,  PATANGAY, Abhilash ,  THAKUR, Pramodsingh Hirasingh ,  ZHANG, Yi ,  BECK, Kenneth C.

Inventor： AVERINA, Viktoria A. ,  HATLESTAD, John D. ,  PATANGAY, Abhilash ,  THAKUR, Pramodsingh Hirasingh ,  ZHANG, Yi ,  BECK, Kenneth C.

IPC: A61N1/365 ,  A61B5/11

Abstract: An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

公开(公告)号：WO2012087696A2

公开(公告)日：2012-06-28

申请号：PCT/US2011064811

申请日：2011-12-14

Applicant: CARDIAC PACEMAKERS INC ,  AVERINA VIKTORIA A ,  HATLESTAD JOHN D ,  PATANGAY ABHILASH ,  THAKUR PRAMODSINGH HIRASINGH ,  ZHANG YI ,  BECK KENNETH C

Inventor： AVERINA VIKTORIA A ,  HATLESTAD JOHN D ,  PATANGAY ABHILASH ,  THAKUR PRAMODSINGH HIRASINGH ,  ZHANG YI ,  BECK KENNETH C

IPC: A61N1/365 ,  A61B5/11

CPC classification number: A61N1/36542 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869

Abstract: An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

Abstract translation: 可植入或其他动态医疗设备包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路利用使用姿势信号获得的姿势数据来确定对象的姿势，并且确定对象的姿势何时处于稳定状态。 测量电路利用从生理信号提取的生理数据在姿势被确定为稳定状态的至少一个时间段期间导出生理测量结果，并且将生理测量结果提供给用户和与确定的稳定性相关联的过程中的至少一个 状态的姿势。

公开(公告)号：WO2010014497A1

公开(公告)日：2010-02-04

申请号：PCT/US2009/051579

申请日：2009-07-23

Applicant: CARDIAC PACEMAKERS, INC. ,  ZHANG, Yi ,  BECK, Kenneth, C. ,  LEWICKE, Aaron ,  ZHANG, Yunlong

Inventor： ZHANG, Yi ,  BECK, Kenneth, C. ,  LEWICKE, Aaron ,  ZHANG, Yunlong

IPC: A61B5/0215

CPC classification number: A61B5/0205 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/4519

Abstract: Various method embodiments of the present invention concern sensing patient- internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

Abstract translation: 本发明的各种方法实施例涉及检测指示生理消耗的患者内部压力测量，基于患者内部的压力测量，感测心外反应数据和对应于心脏的心脏反应数据识别生理用药的一个或多个稳态时期 一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度的等效水平相关联的心脏反应信息进行比较， 以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

公开(公告)号：WO2009048610A1

公开(公告)日：2009-04-16

申请号：PCT/US2008/011641

申请日：2008-10-10

Applicant: CARDIAC PACEMAKERS, INC. ,  LIN, Zheng ,  BECK, Kenneth C. ,  KWOK, Jonathan ,  LEE, Kent ,  PU, Yachuan ,  STAHMANN, Jeffrey E.

Inventor： LIN, Zheng ,  BECK, Kenneth C. ,  KWOK, Jonathan ,  LEE, Kent ,  PU, Yachuan ,  STAHMANN, Jeffrey E.

IPC: A61N1/36

CPC classification number: A61N1/3611 ,  A61B5/0816 ,  A61N1/3601

Abstract: A system and method for treating and/or preventing is described for treating periodic breathing characterized by cyclical hyperventilation and hypoventilation, examples of which include Cheyne-Stokes respiration and central sleep apnea. The system could also be used in the treatment of other conditions involving an impairment of respiratory drive.

Abstract translation: 描述了治疗和/或预防的系统和方法，用于治疗以循环过度换气和通气不足为特征的周期性呼吸，其实例包括Cheyne-Stokes呼吸和中枢性睡眠呼吸暂停。 该系统也可用于治疗涉及呼吸驱动障碍的其他病症。