公开(公告)号：WO2010083086A1

公开(公告)日：2010-07-22

申请号：PCT/US2010/020320

申请日：2010-01-07

Applicant: CARDIAC PACEMAKERS, INC. ,  WARIAR, Ramesh

Inventor： WARIAR, Ramesh

IPC: A61N1/30 ,  A61N1/05 ,  A61N1/32

CPC classification number: A61N1/325 ,  A61N1/306 ,  A61N1/36007

Abstract: A system and method of applying an electric field to the kidney of a subject can reduce renal salt and water retention through the process of electrophoresis. The system includes a first and a second electrode, at least of which is implantably associated with the kidney. The electric field can be controlled to affect the removal of a first constituent (e.g. sodium) from the kidney while the level of a second constituent (e.g. potassium) is maintained within normal physiological range.

Abstract translation: 将电场施加到受试者的肾脏的系统和方法可以通过电泳过程减少肾盐和保水。 该系统包括第一和第二电极，其至少可植入地与肾相关联。 可以控制电场以影响从肾脏中去除第一组分（例如钠），同时将第二组分（例如钾）的水平保持在正常生理范围内。

公开(公告)号：WO2006127594A2

公开(公告)日：2006-11-30

申请号：PCT/US2006019729

申请日：2006-05-23

Applicant: CARDIAC PACEMAKERS INC ,  WARIAR RAMESH ,  SIEJKO KRZYSZTOF Z ,  CARLSON GERRARD M ,  STAHMANN JEFFREY E ,  MAILE KEITH R

Inventor： WARIAR RAMESH ,  SIEJKO KRZYSZTOF Z ,  CARLSON GERRARD M ,  STAHMANN JEFFREY E ,  MAILE KEITH R

IPC: A61B5/02

CPC classification number: A61B7/00 ,  A61N1/08

Abstract: A system to monitor heart sounds, such as to detect a worsening condition of heart failure decompensation. The system comprises a medical device that includes an implantable multi-axis heart sound sensor, operable to produce, for each of at least two nonparallel axes, an electrical signal representative of at least one heart sound, the heart sound associated with mechanical activity of a patient's heart. The device further includes a controller circuit coupled to the heart sound sensor. The controller circuit measures components of the heart sound that respectively correspond to each of the axes.

Abstract translation: 监测心脏声音的系统，例如检测心力衰竭代偿失调的恶化情况。 该系统包括医疗装置，其包括可植入的多轴心音传感器，可操作以针对至少两个不平行的轴中的每一个产生代表至少一个心脏声音的电信号，所述心脏声音与 病人的心。 该装置还包括耦合到心脏声音传感器的控制器电路。 控制器电路测量分别对应于每个轴的心音的分量。

公开(公告)号：WO2010033314A1

公开(公告)日：2010-03-25

申请号：PCT/US2009/052697

申请日：2009-08-04

Applicant: CARDIAC PACEMAKERS, INC. ,  SCHEURER, Elizabeth, S. ,  WARIAR, Ramesh

Inventor： SCHEURER, Elizabeth, S. ,  WARIAR, Ramesh

IPC: A61B5/02

CPC classification number: A61B5/0215 ,  A61B5/0031

Abstract: An implantable system for monitoring a hydration state of a patient and adjusting fluid removal from the patient includes a pressure sensor implantable within an inferior vena cava of the patient and a processor. The pressure sensor senses and generates an output representative of a baseline inferior vena caval pressure value of the patient and chronically senses and generates outputs representative of an inferior vena caval pressure value of the patient. The processor compares differences between the baseline inferior vena caval pressure value and subsequent inferior vena caval pressure values. The processor can reside in another implantable device or in an external device/system.

Abstract translation: 一种用于监测患者的水合状态并调节从患者移除的流体的可植入系统包括可植入患者的下腔静脉内的压力传感器和处理器。 压力传感器感测并产生代表患者的基线下腔静脉压值的输出，并且长期感测并产生代表患者的下腔静脉压值的输出。 处理器比较基线下腔静脉压值与随后的下腔静脉压值之间的差异。 处理器可以驻留在另一个可植入设备中或外部设备/系统中。

公开(公告)号：WO2010042790A3

公开(公告)日：2010-04-15

申请号：PCT/US2009/060118

申请日：2009-10-09

Applicant: CARDIAC PACEMAKERS, INC. ,  ZHANG, Yi ,  STAHMANN, Jeffrey E. ,  SIEJKO, Krzysztof Z. ,  WARIAR, Ramesh ,  THOMPSON, Julie A. ,  HATLESTAD, John D. ,  BECK, Kenneth C.

Inventor： ZHANG, Yi ,  STAHMANN, Jeffrey E. ,  SIEJKO, Krzysztof Z. ,  WARIAR, Ramesh ,  THOMPSON, Julie A. ,  HATLESTAD, John D. ,  BECK, Kenneth C.

IPC: A61B5/02 ,  A61B5/00 ,  A61N1/39 ,  A61B5/085 ,  A61B5/0452 ,  A61B5/12 ,  A61B7/04 ,  A61B5/029 ,  A61B5/0215

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

公开(公告)号：WO2010042790A2

公开(公告)日：2010-04-15

申请号：PCT/US2009060118

申请日：2009-10-09

Applicant: CARDIAC PACEMAKERS INC ,  ZHANG YI ,  STAHMANN JEFFREY E ,  SIEJKO KRZYSZTOF Z ,  WARIAR RAMESH ,  THOMPSON JULIE A ,  HATLESTAD JOHN D ,  BECK KENNETH C

Inventor： ZHANG YI ,  STAHMANN JEFFREY E ,  SIEJKO KRZYSZTOF Z ,  WARIAR RAMESH ,  THOMPSON JULIE A ,  HATLESTAD JOHN D ,  BECK KENNETH C

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0452 ,  A61B5/085 ,  A61B5/12 ,  A61B7/04 ,  A61N1/39

CPC classification number: A61B5/02055 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/029 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/085 ,  A61B5/1118 ,  A61B5/121 ,  A61B5/14542 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36585

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

Abstract translation: 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。

公开(公告)号：WO2008100675A3

公开(公告)日：2008-10-30

申请号：PCT/US2008051289

申请日：2008-01-17

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA ,  ROGER RODOLFO G ,  HARTRANFT THOMAS P ,  WARIAR RAMESH ,  LASSO ANGEL M ,  LAMBERSON GEORGE T

Inventor： ROGER RODOLFO G ,  HARTRANFT THOMAS P ,  WARIAR RAMESH ,  LASSO ANGEL M ,  LAMBERSON GEORGE T

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/34 ,  A61M1/16 ,  A61M1/3413 ,  A61M1/3653 ,  A61M1/3656 ,  A61M5/16831 ,  A61M39/10 ,  A61M2205/13 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  G01N27/07 ,  G01N27/10 ,  G01N33/49

Abstract: An access disconnection system includes an extracorporeal circuit; first and second contacts provided in the extracorporeal circuit; a current source communicating with the first contact and configured to generate a current within fluid flowing through the extracorporeal circuit; and an apparatus positioned to apply a signal at multiple points along a path from the extracorporeal circuit, the signals tending to prevent at least a portion of the current from traveling through a ground path in parallel to the extracorporeal circuit.

Abstract translation: 接入断开系统包括体外电路; 设置在体外回路中的第一和第二触点; 电流源，与所述第一触点连通并且被配置为在流过所述体外回路的流体内产生电流; 以及定位成沿着来自体外回路的路径在多个点处施加信号的装置，所述信号倾向于防止至少一部分电流平行于体外回路行进通过接地路径。

公开(公告)号：WO2012162281A1

公开(公告)日：2012-11-29

申请号：PCT/US2012/038920

申请日：2012-05-22

Applicant: CARDIAC PACEMAKERS, INC. ,  MAHAJAN, Deepa ,  WARIAR, Ramesh ,  SHOME, Shibaji

Inventor： MAHAJAN, Deepa ,  WARIAR, Ramesh ,  SHOME, Shibaji

IPC: G06F19/00

CPC classification number: G06F19/3481 ,  A61M1/14 ,  A61M2205/05 ,  A61M2205/3507 ,  A61M2230/00 ,  A61N1/36117 ,  A61N1/3621 ,  G06F19/00 ,  G16H40/63

Abstract: A system can coordinate operation of a cardiac function management (CFM) device and a renal device, such as during a vulnerable period in which a patient has an increased risk of tachyarrhythmia.

Abstract translation: 系统可以协调心脏功能管理（CFM）装置和肾脏装置的操作，例如在患有快速性心律失常风险增加的脆弱时期。

公开(公告)号：WO2011049716A1

公开(公告)日：2011-04-28

申请号：PCT/US2010/050571

申请日：2010-09-28

Applicant: CARDIAC PACEMAKERS, INC. ,  WARIAR, Ramesh ,  STAHMANN, Jeffrey E. ,  HASTINGS, Roger ,  RUBLE, Stephen ,  HEIL, Ronald W., Jr. ,  HAHN, Stephen J. ,  SHARMA, Arjun

Inventor： WARIAR, Ramesh ,  STAHMANN, Jeffrey E. ,  HASTINGS, Roger ,  RUBLE, Stephen ,  HEIL, Ronald W., Jr. ,  HAHN, Stephen J. ,  SHARMA, Arjun

IPC: A61N1/36 ,  A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/36007 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/37288

Abstract: An implantable cardiorenal stimulator delivers cardiorenal stimulation in response to detection of decompensation associated with heart failure. The cardiorenal stimulation includes delivering renal stimulation pulses to promote diuresis and/or natriureses and delivering cardiac stimulation pulses to enhance the diuretic and/or natriuretic effects of the renal stimulation pulses.

Abstract translation: 可植入的心肾刺激器响应于与心力衰竭相关的代偿失调的检测而提供心脏刺激。 心脏刺激包括递送肾刺激脉冲以促进利尿和/或利钠肽并递送心脏刺激脉冲以增强肾刺激脉冲的利尿和/或利尿钠效应。

公开(公告)号：WO2010129590A1

公开(公告)日：2010-11-11

申请号：PCT/US2010/033600

申请日：2010-05-04

Applicant: CARDIAC PACEMAKERS, INC. ,  WARIAR, Ramesh

Inventor： WARIAR, Ramesh

IPC: A61N1/32 ,  A61B5/053 ,  A61B5/08 ,  A61N1/362 ,  A61N1/20

CPC classification number: A61N1/3601 ,  A61B5/0537 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4878 ,  A61N1/205 ,  A61N1/32 ,  A61N1/3627

Abstract: System and method of applying electric fields to a patient's lung(s) to reduce pulmonary edema. The system includes a first electrode and a second electrode, at least one of which is associated with the lung. The electric field can be controlled so as to modulate a level of fluid in the lung.

Abstract translation: 将电场施加到患者肺部以减少肺水肿的系统和方法。 该系统包括第一电极和第二电极，其中至少一个与肺相关联。 可以控制电场以便调节肺中的液体水平。

公开(公告)号：WO2008100675A2

公开(公告)日：2008-08-21

申请号：PCT/US2008/051289

申请日：2008-01-17

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE S.A. ,  ROGER, Rodolfo, G. ,  HARTRANFT, Thomas, P. ,  WARIAR, Ramesh ,  LASSO, Angel, M. ,  LAMBERSON, George, T.

Inventor： ROGER, Rodolfo, G. ,  HARTRANFT, Thomas, P. ,  WARIAR, Ramesh ,  LASSO, Angel, M. ,  LAMBERSON, George, T.

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/34 ,  A61M1/16 ,  A61M1/3413 ,  A61M1/3653 ,  A61M1/3656 ,  A61M5/16831 ,  A61M39/10 ,  A61M2205/13 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/50 ,  G01N27/07 ,  G01N27/10 ,  G01N33/49

Abstract: An access disconnection system includes an extracorporeal circuit; first and second contacts provided in the extracorporeal circuit; a current source communicating with the first contact and configured to generate a current within fluid flowing through the extracorporeal circuit; and an apparatus positioned to apply a signal at multiple points along a path from the extracorporeal circuit, the signals tending to prevent at least a portion of the current from traveling through a ground path in parallel to the extracorporeal circuit.

Abstract translation: 一种接入断开系统，包括体外电路; 提供在体外循环中的第一和第二触点; 电流源，与所述第一触点通信并且被配置为在流过所述体外电路的流体内产生电流; 以及定位成沿着来自体外电路的路径的多个点处施加信号的装置，所述信号倾向于防止电流的至少一部分平行于体外电路行进通过接地路径。