公开(公告)号：WO2009011886A1

公开(公告)日：2009-01-22

申请号：PCT/US2008/008738

申请日：2008-07-17

Applicant: CARDIAC PACEMAKERS, INC. ,  LEWICKE, Aaron ,  HATLESTAD, John D. ,  PATANGAY, Abhilash

Inventor： LEWICKE, Aaron ,  HATLESTAD, John D. ,  PATANGAY, Abhilash

IPC: A61B5/11

CPC classification number: A61B5/1112 ,  A61B5/1116 ,  A61B5/686

Abstract: An example method includes monitoring a first posture including a first lateral decubitus posture (LDP), recording a first LDP record based on the first LDP, computing a first posture trend based on the first LDP record and determining and providing a wellness indication based on the first posture trend.

Abstract translation: 一种示例性方法包括监视包括第一侧卧位姿势（LDP）的第一姿势，基于第一LDP记录第一LDP记录，基于第一LDP记录计算第一姿态趋势，并基于该第一LDP记录确定并提供健康指示 第一姿势趋势。

公开(公告)号：WO2011100422A1

公开(公告)日：2011-08-18

申请号：PCT/US2011/024339

申请日：2011-02-10

Applicant: CARDIAC PACEMAKERS, INC. ,  HATLESTAD, John D. ,  CHAN, Tsz Ping

Inventor： HATLESTAD, John D. ,  CHAN, Tsz Ping

IPC: A61B5/103 ,  A61B5/11 ,  A61N1/365 ,  G01P15/18

CPC classification number: A61N1/36542 ,  A61B5/1116 ,  A61B5/1117 ,  A61B5/1118 ,  A61B5/686 ,  A61B2560/0223 ,  A61B2562/0219 ,  A61N1/3925 ,  G01P15/18

Abstract: A device can include a multi-dimensional posture sensor that provides an electrical sensor output representative of alignment of first, second, and third non-parallel axes of the device with the gravitational field of the earth, and a processor that includes a calibration circuit and a posture circuit. The calibration circuit measures a first sensor output for the first device axis and a second sensor output for one of a second device axis while the subject is in a first specified posture, measures sensor outputs for the first, second, and third device axes while the subject is in a second specified posture, calculates one or more coordinate transformations, generates transformed sensor outputs using the coordinate transformations, and calibrates the posture sensor by calculating a calibration transformation using the first and second sensor outputs and the transformed sensor outputs. The posture circuit determines a subsequent posture of the subject using the posture sensor.

Abstract translation: 设备可以包括多维姿态传感器，其提供表示设备的第一，第二和第三非平行轴线与地球的重力场的对准的电传感器输出，以及包括校准电路和 姿势电路。 校准电路测量第一设备轴的第一传感器输出和第二设备轴的第二传感器输出，同时对象处于第一指定姿势，测量第一，第二和第三设备轴的传感器输出，同时 受试者处于第二指定姿势，计算一个或多个坐标变换，使用坐标变换生成变换的传感器输出，并且通过使用第一和第二传感器输出和变换的传感器输出计算校准变换来校准姿态传感器。 姿势电路使用姿态传感器来确定对象的后续姿势。

公开(公告)号：WO2010042790A3

公开(公告)日：2010-04-15

申请号：PCT/US2009/060118

申请日：2009-10-09

Applicant: CARDIAC PACEMAKERS, INC. ,  ZHANG, Yi ,  STAHMANN, Jeffrey E. ,  SIEJKO, Krzysztof Z. ,  WARIAR, Ramesh ,  THOMPSON, Julie A. ,  HATLESTAD, John D. ,  BECK, Kenneth C.

Inventor： ZHANG, Yi ,  STAHMANN, Jeffrey E. ,  SIEJKO, Krzysztof Z. ,  WARIAR, Ramesh ,  THOMPSON, Julie A. ,  HATLESTAD, John D. ,  BECK, Kenneth C.

IPC: A61B5/02 ,  A61B5/00 ,  A61N1/39 ,  A61B5/085 ,  A61B5/0452 ,  A61B5/12 ,  A61B7/04 ,  A61B5/029 ,  A61B5/0215

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

公开(公告)号：WO2010042790A2

公开(公告)日：2010-04-15

申请号：PCT/US2009060118

申请日：2009-10-09

Applicant: CARDIAC PACEMAKERS INC ,  ZHANG YI ,  STAHMANN JEFFREY E ,  SIEJKO KRZYSZTOF Z ,  WARIAR RAMESH ,  THOMPSON JULIE A ,  HATLESTAD JOHN D ,  BECK KENNETH C

Inventor： ZHANG YI ,  STAHMANN JEFFREY E ,  SIEJKO KRZYSZTOF Z ,  WARIAR RAMESH ,  THOMPSON JULIE A ,  HATLESTAD JOHN D ,  BECK KENNETH C

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0452 ,  A61B5/085 ,  A61B5/12 ,  A61B7/04 ,  A61N1/39

CPC classification number: A61B5/02055 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/029 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/085 ,  A61B5/1118 ,  A61B5/121 ,  A61B5/14542 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36585

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

Abstract translation: 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。

公开(公告)号：WO2012091848A2

公开(公告)日：2012-07-05

申请号：PCT/US2011062917

申请日：2011-12-01

Applicant: CARDIAC PACEMAKERS INC ,  ARCOT-KRISHNAMURTHY SHANTHA ,  ZHANG YI ,  HATLESTAD JOHN D

Inventor： ARCOT-KRISHNAMURTHY SHANTHA ,  ZHANG YI ,  HATLESTAD JOHN D

IPC: A61N1/36 ,  A61B5/053

CPC classification number: A61N1/36053 ,  A61B5/0538 ,  A61N1/36117 ,  A61N1/36135 ,  A61N1/36521

Abstract: A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

Abstract translation: 设备实施例被配置为将迷走神经刺激治疗（VST）递送至患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。

公开(公告)号：WO2008054580A2

公开(公告)日：2008-05-08

申请号：PCT/US2007020425

申请日：2007-09-20

Applicant: CARDIAC PACEMAKERS INC ,  ZHANG YI ,  HATLESTAD JOHN D ,  CARLSON GERRARD M ,  DALAL YOUSUFALI ,  BROCKWAY MARINA V ,  LEE KENT ,  KUENZLER RICHARD O ,  HARO CARLOS ,  SIEJKO KRZYSZTOF Z ,  PATANGAY ABHILASH

Inventor： ZHANG YI ,  HATLESTAD JOHN D ,  CARLSON GERRARD M ,  DALAL YOUSUFALI ,  BROCKWAY MARINA V ,  LEE KENT ,  KUENZLER RICHARD O ,  HARO CARLOS ,  SIEJKO KRZYSZTOF Z ,  PATANGAY ABHILASH

IPC: A61B5/02

CPC classification number: A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585

Abstract: The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. Baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. Prediction processing may be performed by the at-least one implantable device or by an external device in communication therewith. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

Abstract translation: 使用至少一个可植入装置自动评估或预测对象的健康状态。 在变化的示例中，通过感测或接收关于具有昼夜节律的至少一个生理过程的信息来确定健康状态，该过程的存在，不存在或基线变化与即将发生的疾病相关联，并且将这种节律与基线昼夜节律预测标准进行比较。 除昼夜节律外的其他时间生物节律也可以使用。 基线预测标准可以使用一个或多个过去对非疾病健康状态中的受试者或受试者群体的生理过程观察来导出。 预测处理可以由至少一个可植入装置或通过与其通信的外部装置来执行。 还讨论了响应于健康状态而调用治疗的系统和方法，例如以防止或最小化预测即将发生的心力衰竭的后果。

公开(公告)号：WO2010030454A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/053087

申请日：2009-08-07

Applicant: Cardiac Pacemakers, Inc. ,  HATLESTAD, John D. ,  TRAN, Binh C. ,  MI, Bin ,  HEIL, Ronald W.

Inventor： HATLESTAD, John D. ,  TRAN, Binh C. ,  MI, Bin ,  HEIL, Ronald W.

IPC: A61B5/03

CPC classification number: A61B5/0205 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/036 ,  A61B5/201 ,  A61B5/416 ,  A61B5/6846

Abstract: An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor (12) implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor (18) is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device (14) or in an external device/system (16).

Abstract translation: 用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器（12），用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期 以周期性间隔感测和产生代表患者的腹内压力值的输出。 提供至少一个第二可植入传感器（18），用于感测和产生代表患者的第二生理参数的输出。 另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。 处理器可以驻留在另一可植入装置（14）中或在外部装置/系统（16）中。

公开(公告)号：WO2012091848A3

公开(公告)日：2012-07-05

申请号：PCT/US2011/062917

申请日：2011-12-01

Applicant: CARDIAC PACEMAKERS, INC. ,  ARCOT-KRISHNAMURTHY, Shantha ,  ZHANG, Yi ,  HATLESTAD, John D.

Inventor： ARCOT-KRISHNAMURTHY, Shantha ,  ZHANG, Yi ,  HATLESTAD, John D.

IPC: A61N1/36 ,  A61B5/053

Abstract: A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

公开(公告)号：WO2012087696A3

公开(公告)日：2012-06-28

申请号：PCT/US2011/064811

申请日：2011-12-14

Applicant: CARDIAC PACEMAKERS, INC. ,  AVERINA, Viktoria A. ,  HATLESTAD, John D. ,  PATANGAY, Abhilash ,  THAKUR, Pramodsingh Hirasingh ,  ZHANG, Yi ,  BECK, Kenneth C.

Inventor： AVERINA, Viktoria A. ,  HATLESTAD, John D. ,  PATANGAY, Abhilash ,  THAKUR, Pramodsingh Hirasingh ,  ZHANG, Yi ,  BECK, Kenneth C.

IPC: A61N1/365 ,  A61B5/11

Abstract: An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

公开(公告)号：WO2012087696A2

公开(公告)日：2012-06-28

申请号：PCT/US2011064811

申请日：2011-12-14

Applicant: CARDIAC PACEMAKERS INC ,  AVERINA VIKTORIA A ,  HATLESTAD JOHN D ,  PATANGAY ABHILASH ,  THAKUR PRAMODSINGH HIRASINGH ,  ZHANG YI ,  BECK KENNETH C

Inventor： AVERINA VIKTORIA A ,  HATLESTAD JOHN D ,  PATANGAY ABHILASH ,  THAKUR PRAMODSINGH HIRASINGH ,  ZHANG YI ,  BECK KENNETH C

IPC: A61N1/365 ,  A61B5/11

CPC classification number: A61N1/36542 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869

Abstract: An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

Abstract translation: 可植入或其他动态医疗设备包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路利用使用姿势信号获得的姿势数据来确定对象的姿势，并且确定对象的姿势何时处于稳定状态。 测量电路利用从生理信号提取的生理数据在姿势被确定为稳定状态的至少一个时间段期间导出生理测量结果，并且将生理测量结果提供给用户和与确定的稳定性相关联的过程中的至少一个 状态的姿势。