公开(公告)号：AU640514B2

公开(公告)日：1993-08-26

申请号：AU8279391

申请日：1991-08-28

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： ARTHUR PAUL SCHAAP ,  LOUIS J. ROMANO ,  JAIDEV S. GOUDAR

IPC: C07D207/404 ,  C07D207/46 ,  C07D321/00 ,  C07D405/12 ,  C07D407/12 ,  C07D495/04 ,  C07F7/18 ,  C09K11/07 ,  G01N33/533

Abstract: Dioxetanes which couple with organic and biological molecules of the formula: wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

公开(公告)号：AU637194B2

公开(公告)日：1993-05-20

申请号：AU7183391

申请日：1990-12-12

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： ARTHUR PAUL SCHAAP

IPC: C07B37/04 ,  A01N1/02 ,  A61B5/154 ,  A61F6/04 ,  A61J1/05 ,  A61K31/12 ,  A61K31/13 ,  A61K31/16 ,  A61K31/215 ,  A61K31/35 ,  A61K35/14 ,  A61K45/00 ,  A61K45/06 ,  A61L2/00 ,  A61L2/18 ,  A61L2/26 ,  A61L15/00 ,  A61M1/02 ,  A61P31/12 ,  A61P37/04 ,  C07B61/00 ,  C07C37/00 ,  C07C37/62 ,  C07C39/38 ,  C07C41/01 ,  C07C41/18 ,  C07C43/178 ,  C07C43/23 ,  C07C51/15 ,  C07C305/24 ,  C07D207/46 ,  C07D307/87 ,  C07D311/58 ,  C07D311/82 ,  C07D321/00 ,  C07D405/12 ,  C07D407/10 ,  C07D407/12 ,  C07D417/12 ,  C07D493/10 ,  C07D495/04 ,  C07F7/18 ,  C07F9/6541 ,  C07F9/655 ,  C07F9/6558 ,  C07F9/6561 ,  C07H15/203

Abstract: An improved process for the preparation of vinyl ethers by the coupling reaction of an ester of the formula with a carbonyl containing compound of the formula wherein A and R are passive organic groups and OY is a hydroxyl group or OP where P is a protecting group is described. The ester and the carbonyl containing compound are reacted in an organic solvent with a titanium salt, a metallic reducing agent and an amine base to provide the vinyl ether. The reaction is safe and produces high yields. The vinyl ethers are useful for producing dioxetanes which produce light upon triggering.