公开(公告)号：AU640514B2

公开(公告)日：1993-08-26

申请号：AU8279391

申请日：1991-08-28

Applicant: BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY

Inventor： ARTHUR PAUL SCHAAP ,  LOUIS J. ROMANO ,  JAIDEV S. GOUDAR

IPC: C07D207/404 ,  C07D207/46 ,  C07D321/00 ,  C07D405/12 ,  C07D407/12 ,  C07D495/04 ,  C07F7/18 ,  C09K11/07 ,  G01N33/533

Abstract: Dioxetanes which couple with organic and biological molecules of the formula: wherein X is a leaving group which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.