公开(公告)号：WO2002070707A3

公开(公告)日：2002-09-12

申请号：PCT/US2001/049168

申请日：2001-12-18

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

Inventor： PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2002070660A3

公开(公告)日：2002-09-12

申请号：PCT/US2002/006485

申请日：2002-03-04

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS ,  KEKUDA, Ramesh ,  CONLEY, Pamela, B. ,  BIN-YANG, Ruey ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, Newman ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  ZERHUSEN, Bryan, D. ,  KOMUVES, Laszlo ,  PADIGARU, Muralidhara

Inventor： KEKUDA, Ramesh ,  CONLEY, Pamela, B. ,  BIN-YANG, Ruey ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, Newman ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  ZERHUSEN, Bryan, D. ,  KOMUVES, Laszlo ,  PADIGARU, Muralidhara

IPC: C07K14/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

公开(公告)号：WO02070660A2

公开(公告)日：2002-09-12

申请号：PCT/US0206485

申请日：2002-03-04

Applicant: CURAGEN CORP ,  COR THERAPEUTICS ,  KEKUDA RAMESH ,  CONLEY PAMELA B ,  BIN-YANG RUEY ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES NEWMAN ,  SHIMKETS RICHARD A ,  LEACH MARTIN D ,  ZERHUSEN BRYAN D ,  KOMUVES LASZLO ,  PADIGARU MURALIDHARA

Inventor： KEKUDA RAMESH ,  CONLEY PAMELA B ,  BIN-YANG RUEY ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES NEWMAN ,  SHIMKETS RICHARD A ,  LEACH MARTIN D ,  ZERHUSEN BRYAN D ,  KOMUVES LASZLO ,  PADIGARU MURALIDHARA

IPC: A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码相同的多肽和核酸。 还揭示了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO2012057789A1

公开(公告)日：2012-05-03

申请号：PCT/US2010/054751

申请日：2010-10-29

Applicant: TECHTRONIC FLOOR CARE TECHNOLOGY LIMITED ,  DAVIS, Josh ,  MAUER, Edgar ,  JENSEN, Jeffrey ,  BO, Deng ,  BIN, Yang Ying

Inventor： DAVIS, Josh ,  MAUER, Edgar ,  JENSEN, Jeffrey ,  BO, Deng ,  BIN, Yang Ying

IPC: B02C18/28 ,  B02C18/30

CPC classification number: B02C18/0007 ,  B02C23/04

Abstract: A shredder includes a shredder housing with a top head and a shredder mechanism receptacle. The top head has at least a first slot for receiving articles to be shredded. The shredder mechanism receptacle is connected to the top head for receiving a cutting assembly capable of shredding paper. A safety device is disposed in the shredder housing. The safety device includes a slot guard and gear system for selectively blocking the first slot.

Abstract translation: 切碎机包括具有顶部头部和粉碎机构容器的切碎机壳体。 顶部头部至少具有用于接收待切割物品的第一槽。 切碎机构插座连接到顶部头部，用于接收能够切碎纸的切割组件。 安全装置设置在粉碎机壳体中。 安全装置包括用于选择性地阻挡第一槽的槽护罩和齿轮系统。

公开(公告)号：WO02070707A2

公开(公告)日：2002-09-12

申请号：PCT/US0149168

申请日：2001-12-18

Applicant: CURAGEN CORP ,  COR THERAPEUTICS INC ,  PADIGARU MURALIDHARA ,  GERLACH VALERIE L ,  SMITHSON GLENNDA ,  STONE DAVID ,  BIN-YANG RUEY ,  CONLEY PAMELA ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  KEKUDA RAMESH ,  CASMAN STACIE J ,  EDINGER SCHLOMIT ,  MACDOUGALL JOHN R

Inventor： PADIGARU MURALIDHARA ,  GERLACH VALERIE L ,  SMITHSON GLENNDA ,  STONE DAVID ,  BIN-YANG RUEY ,  CONLEY PAMELA ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES N ,  KEKUDA RAMESH ,  CASMAN STACIE J ,  EDINGER SCHLOMIT ,  MACDOUGALL JOHN R

IPC: A61K38/00 ,  C07K14/705 ,  C12N15/12 ,  A61K31/7088 ,  A61K38/17 ,  A61K39/395 ,  C07K16/28 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K2039/505

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

公开(公告)号：US20240188772A1

公开(公告)日：2024-06-13

申请号：US18139967

申请日：2023-04-27

Applicant: Bin YANG ,  Qi CHEN ,  Xiang Ye LIN

Inventor： Bin YANG ,  Qi CHEN ,  Xiang Ye LIN

IPC: A47K13/26

CPC classification number: A47K13/26

Abstract: A quick assembly and disassembly structure of a toilet seat base, including a supporting base, base boards, lid bodies, and axial hole portions and connecting portions on the supporting base; each connecting portion is provided with a sliding groove; each base board is slidable back and forth within a corresponding sliding groove and non-movable vertically within the corresponding sliding groove; one end of each lid body is pivotally connected with a corresponding connecting portion; a bottom surface of each lid body is provided with positioning ribs; a top surface of each connecting portion is provided with positioning holes; the positioning holes of each connecting portion are in communication to a corresponding sliding groove. When each lid body is closed, the positioning ribs pass through the positioning holes and fit with the positioning grooves, so that each base board and a corresponding sliding groove are fixed.

公开(公告)号：US20240188769A1

公开(公告)日：2024-06-13

申请号：US18143078

申请日：2023-05-04

Applicant: Bin YANG ,  Qi CHEN ,  Xiang Ye LIN

Inventor： Bin YANG ,  Qi CHEN ,  Xiang Ye LIN

IPC: A47K13/06

CPC classification number: A47K13/06

Abstract: A novel toilet seat structure, including a supporting base, a toilet seat, fixing blocks and two first buffered-descent modules; the toilet seat includes a child seat that has a child seat body and a first decorative lid; a rear end of the child seat body is provided with a shaft portion including first shaft sleeves and a sliding groove; the first decorative lid is detachably fitted with an opening part of the sliding groove; two ends of the supporting base are provided with second shaft sleeves respectively; a fixing block is embedded inside and being limited from rotating circumferentially in each second shaft sleeve; each first buffered-descent module is embedded inside the shaft portion through the sliding groove, and then passes through a corresponding first shaft sleeve and is then connected to a corresponding fixing block.

公开(公告)号：US10131889B1

公开(公告)日：2018-11-20

申请号：US15810007

申请日：2017-11-11

Applicant: Liming Liu ,  Bin Yang

Inventor： Liming Liu ,  Bin Yang

IPC: C12N9/20 ,  C12N15/74 ,  C12N15/00 ,  C12P9/00

Abstract: The present invention relates to the field of bioengineering. It provides a Candida antarctica lipase B mutant and its application. The mutant enzyme overcomes the limit of the parent enzyme that can exhibit high enantioselectivity towards (R)-3-TBDMSO glutaric acid methyl monoester only at temperatures below 5° C. The mutant enzyme successfully increased R-ee value at 5-70° C. The mutant D223V/A281S exhibits high R-ee value (>99%), high conversion rate (80%), and high space-time yield (107.54 g L−1 d−1). The present invention lays a foundation for industrial production of (R)-3-TBDMSO glutaric acid methyl monoester using a biosynthesis approach and provide insights into conformational dynamics-based enzyme design.

公开(公告)号：US09182661B2

公开(公告)日：2015-11-10

申请号：US13996967

申请日：2011-12-24

Applicant: Haifeng Li ,  Bin Yang

Inventor： Haifeng Li ,  Bin Yang

IPC: H04N1/405 ,  G03F5/20

CPC classification number: G03F5/20 ,  H04N1/4055

Abstract: The present application provides a screen method for intaglio printing, comprising: dividing multiple classes of regions according to a brightness range; and generating screen dots with various screen patterns for the grouped classes of regions. The present application also provides a screen device for intaglio printing, comprising: a dividing module configured to group multiple classes of regions according to the brightness range; and a generating module configured to generate screen dots with various screen patterns for the grouped classes of regions. Since multiple kinds of screen patterns are applied in the technical solutions in present application, the problem, i.e., water ripple will occur in the prior art, may be addressed, so as to improve the quality of printing.

Abstract translation: 本申请提供了一种用于凹版印刷的屏幕方法，包括：根据亮度范围划分多个类别的区域; 并且为分组的区域类别生成具有各种屏幕图案的屏幕点。 本申请还提供了一种用于凹版印刷的屏幕装置，包括：分割模块，被配置为根据亮度范围对多个类别的区域进行分组; 以及生成模块，被配置为生成用于所述分组的区域类别的各种屏幕图案的屏幕点。 由于在本申请中的技术方案中应用了多种屏幕图案，所以可以解决现有技术中出现的水波纹问题，以提高打印质量。

公开(公告)号：US09134079B2

公开(公告)日：2015-09-15

申请号：US12652027

申请日：2010-01-04

Applicant: Anna Lee Tonkovich ,  Bin Yang ,  Steven T. Perry ,  Sean P. Fitzgerald ,  Ravi Arora ,  Robert Luzenski ,  Thomas D. Yuschak

Inventor： Anna Lee Tonkovich ,  Bin Yang ,  Steven T. Perry ,  Sean P. Fitzgerald ,  Ravi Arora ,  Robert Luzenski ,  Thomas D. Yuschak

IPC: B01J10/00 ,  F28F13/06 ,  B01J19/00 ,  B01L3/00

CPC classification number: F28F13/06 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00995 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/086 ,  F28F2260/02 ,  Y10T137/0396

Abstract: The invention provides apparatuses and techniques for controlling flow between a manifold and two or more connecting microchannels. Flow between plural connecting microchannels, that share a common manifold, can be made more uniform by the use of flow straighteners and distributors that equalize flow in connecting channels. Alternatively, flow can be made more uniform by sections of narrowed diameter within the channels. Methods of making apparatus and methods of conducting unit operations in connecting channels are also described.

Abstract translation: 本发明提供用于控制歧管和两个或更多个连接微通道之间的流动的装置和技术。 通过使用均衡连接通道中的流动的流平衡器和分配器，可以使共享共同歧管的多个连接微通道之间的流动更均匀。 或者，可以通过通道内的变窄直径的部分使流动更均匀。 还描述了在连接通道中进行单元操作的装置和方法的方法。