公开(公告)号：WO2011028834A3

公开(公告)日：2011-07-07

申请号：PCT/US2010047573

申请日：2010-09-01

Applicant: LIFE TECHNOLOGIES CORP ,  WOJTOWICZ JANUSZ ,  DAHLHOFF GEOFFREY ,  GRUNEWALD DOUGLAS W ,  CONNER THOMAS A

Inventor： WOJTOWICZ JANUSZ ,  DAHLHOFF GEOFFREY ,  GRUNEWALD DOUGLAS W ,  CONNER THOMAS A

IPC: G06F1/20 ,  H05K7/20

CPC classification number: H01L21/4882 ,  F28D2021/0029 ,  H01L23/467 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The present teachings disclose various embodiments of a thermal block assembly having low thermal non-uniformity throughout the thermal block assembly. Accordingly, various embodiments of thermal block assemblies having such low thermal non-uniformity provide for desired performance of bioanalysis instrumentation utilizing such thermal block assemblies.

Abstract translation: 本教导公开了整个热块组件中具有低热不均匀性的热块组件的各种实施例。 因此，具有这种低热不均匀性的热块组件的各种实施例提供了利用这种热块组件的生物分析仪器的期望性能。

公开(公告)号：WO2011127386A3

公开(公告)日：2011-10-13

申请号：PCT/US2011/031750

申请日：2011-04-08

Applicant: LIFE TECHNOLOGIES CORPORATION ,  CONNER, Thomas, A ,  LIM, Chee Kiong ,  PALLAS, Michael, C. ,  CHING, Chee Wee

Inventor： CONNER, Thomas, A ,  LIM, Chee Kiong ,  PALLAS, Michael, C. ,  CHING, Chee Wee

IPC: C12Q1/68 ,  C12M1/38 ,  G01N33/50

Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

公开(公告)号：WO2011127386A2

公开(公告)日：2011-10-13

申请号：PCT/US2011031750

申请日：2011-04-08

Applicant: LIFE TECHNOLOGIES CORP ,  CONNER THOMAS A ,  LIM CHEE KIONG ,  PALLAS MICHAEL C ,  CHING CHEE WEE

Inventor： CONNER THOMAS A ,  LIM CHEE KIONG ,  PALLAS MICHAEL C ,  CHING CHEE WEE

IPC: C12Q1/68 ,  C12M1/38 ,  G01N33/50

CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1894

Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

Abstract translation: 提供了一种用于提高热不均匀性的聚合酶链反应（PCR）的方法。 该方法包括通过第一传感器测量样品块的第一样品块扇区的第一温度，并由第二传感器测量与第一样品块相邻的样品块的第二样品块扇区的第二温度 样品块部门。 该方法还包括通过热电控制器计算第一温度和第二温度之间的温度差，并且由热电控制器通过使用一个或多个温度控制器来调节基于温差的第一样品块扇区的第一温度 更多热电冷却器。 一个或多个热电冷却器被配置为通过调节从热电控制器输出的功率来加热或冷却第一样品块扇区。

公开(公告)号：WO2011028834A2

公开(公告)日：2011-03-10

申请号：PCT/US2010/047573

申请日：2010-09-01

Applicant: LIFE TECHNOLOGIES CORPORATION ,  WOJTOWICZ, Janusz ,  DAHLHOFF, Geoffrey ,  GRUNEWALD, Douglas W. ,  CONNER, Thomas A.

Inventor： WOJTOWICZ, Janusz ,  DAHLHOFF, Geoffrey ,  GRUNEWALD, Douglas W. ,  CONNER, Thomas A.

IPC: G06F1/20 ,  H05K7/20

CPC classification number: H01L21/4882 ,  F28D2021/0029 ,  H01L23/467 ,  H01L2924/0002 ,  H01L2924/00

Abstract: The present teachings disclose various embodiments of a thermal block assembly having low thermal non-uniformity throughout the thermal block assembly. Accordingly, various embodiments of thermal block assemblies having such low thermal non-uniformity provide for desired performance of bioanalysis instrumentation utilizing such thermal block assemblies.

Abstract translation: 本教导公开了在整个热块组件中具有低热不均匀性的热块组件的各种实施例。 因此，具有这种低热不均匀性的热块组件的各种实施例提供利用这种热块组件的生物分析仪器的期望性能。