-
1.发明申请PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS 审中-公开便携式光纤基于探针的光谱扫描仪用于快速诊断
公开(公告)号：WO2013103475A3
公开(公告)日：2015-06-18
申请号：PCT/US2012068795
申请日：2012-12-10
Applicant: MASSACHUSETTS INST TECHNOLOGY , LUE NIYOM , DASARI RAMACHANDRA , BARMAN ISHAN , DINGARI NARAHARA CHARI , KANG JEON WOONG
Inventor： LUE NIYOM , DASARI RAMACHANDRA , BARMAN ISHAN , DINGARI NARAHARA CHARI , KANG JEON WOONG , FELD MICHAEL
IPC: A61B6/00
CPC classification number: G01N21/645 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/4738 , G01N21/65 , G01N2021/6417
Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
Abstract translation: 用于疾病诊断的组织光谱扫描的多模式探针系统。 该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。
-
2.发明申请PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS 审中-公开便携式光纤基于探针的光谱扫描仪用于快速诊断
公开(公告)号：WO2013103475A2
公开(公告)日：2013-07-11
申请号：PCT/US2012/068795
申请日：2012-12-10
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LUE, Niyom , DASARI, Ramachandra , BARMAN, Ishan , DINGARI, Narahara, Chari , KANG, Jeon, Woong
Inventor： LUE, Niyom , DASARI, Ramachandra , BARMAN, Ishan , DINGARI, Narahara, Chari , KANG, Jeon, Woong
IPC: A61B6/00
CPC classification number: G01N21/645 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/4738 , G01N21/65 , G01N2021/6417
Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
Abstract translation: 用于疾病诊断的组织光谱扫描的多模式探针系统。 该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。
-
公开(公告)号：WO2012019102A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/046750
申请日：2011-08-05
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BARMAN, Ishan , DINGARI, Narahara, Chari , DASARI, Ramachandra, R. , KONG, Chae-ryon , FELD, David , HEARN, Alison , FELD, Jonathan
Inventor： BARMAN, Ishan , DINGARI, Narahara, Chari , DASARI, Ramachandra, R. , KONG, Chae-ryon
CPC classification number: A61B5/14532 , A61B5/1455 , A61B5/4312 , A61B5/444 , A61B2560/0223 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/65 , G01N2201/129
Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
Abstract translation: 本发明还涉及特定过滤器组合的选择，其可以提供足够的信息用于多变量校准以提取复杂生物系统中的精确分析物浓度。 本发明还描述了引起小型化设计的波长间隔选择方法。 最后，本发明提出了多种波长选择方法和小型化分光设备设计以及从一个域（波长选择）到另一个域（设计参数）映射的必要工具。 信息谱带的这种选择在使得特别采用拉曼光谱和其他光谱技术的任何临床诊断仪器的小型化方面具有广泛的范围。
-
公开(公告)号：WO2008008265A9
公开(公告)日：2008-04-10
申请号：PCT/US2007015518
申请日：2007-07-06
Applicant: MASSACHUSETTS INST TECHNOLOGY , SON HYUNGBIN , KONG JING , DASARI RAMACHANDRA , DRESSELHAUS MILDRED
Inventor： SON HYUNGBIN , KONG JING , DASARI RAMACHANDRA , DRESSELHAUS MILDRED
CPC classification number: G02B6/34 , G01J3/02 , G01J3/021 , G01J3/06 , G01J3/1804 , G01J3/22 , G02B5/1828 , G02B5/1866 , G02B27/4244 , H01S3/1055 , H01S3/213 , H01S5/141
Abstract: A tunable transmissive grating comprises a transmissive dispersive element (1), a reflective element (2) and an angle ϑ formed between the two elements. A first optical path is formed according to the angle ϑ, wherein light dispersing from the dispersive element is directed onto the reflective element and reflects therefrom. At least one element is rotatable about a rotational center (6) to cause a second optical path and thereby tune the wavelength of the light reflecting from the reflective element. Both elements can be rotatable together around a common rotational center point (6) according to certain embodiments, and/or each element can be independently rotated around a rotational axis associated only with that element. According to some embodiments, the relative angle ϑ formed between the elements is held constant; however, in other embodiments ϑ can vary. A control system can be used to operate the device.
Abstract translation: 可调谐透射光栅包括透射色散元件（1），反射元件（2）和在两个元件之间形成的角度θ。 根据角度θ形成第一光路，其中从色散元件散射的光被引导到反射元件上并从其反射。 至少一个元件可围绕旋转中心（6）旋转以产生第二光路并由此调节从反射元件反射的光的波长。 根据某些实施例，两个元件可围绕共同的旋转中心点（6）一起旋转，并且/或者每个元件可以独立地围绕仅与该元件相关联的旋转轴旋转。 根据一些实施例，元件之间形成的相对角度θ保持不变; 然而，在其他实施例中θ可以变化。 控制系统可以用来操作设备。
-
公开(公告)号：WO2008008265A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/015518
申请日：2007-07-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SON, Hyungbin , KONG, Jing , DASARI, Ramachandra , DRESSELHAUS, Mildred
Inventor： SON, Hyungbin , KONG, Jing , DASARI, Ramachandra , DRESSELHAUS, Mildred
Abstract: A tunable transmissive grating comprises a transmissive dispersive element (1), a reflective element (2) and an angle ϑ formed between the two elements. A first optical path is formed according to the angle ϑ, wherein light dispersing from the dispersive element is directed onto the reflective element and reflects therefrom. At least one element is rotatable about a rotational center (6) to cause a second optical path and thereby tune the wavelength of the light reflecting from the reflective element. Both elements can be rotatable together around a common rotational center point (6) according to certain embodiments, and/or each element can be independently rotated around a rotational axis associated only with that element. According to some embodiments, the relative angle ϑ formed between the elements is held constant; however, in other embodiments ϑ can vary. A control system can be used to operate the device.
-
Patent Agency Ranking
公开(公告)号：WO2009009081A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/008447
申请日：2008-07-10
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CHOI, Wonshik , DASARI, Ramachandra, Rao , FANG-YEN, Christopher, M. , FELD, Michael, S.
CPC classification number: G01N21/45 , G01N21/51 , G01N21/6458 , G01N21/6486 , G01N2021/458 , G01N2201/061 , G01N2201/105 , G01N2201/12
Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase- shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time -dependent changes in cell structure and the quantitative characterization of specimen- induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
Abstract translation: 本发明涉及使用具有可变照射角的相移激光干涉显微镜在活体或非活体细胞，组织或生物中定量三维绘制折射率的系统和方法。 一个优选的实施方案提供了细胞和多细胞生物体的层析成像，以及细胞结构的时间依赖性变化以及在组织光散射中具有多种应用的高分辨率显微镜中样本诱导的像差的定量表征。
-
公开(公告)号：WO2008008265A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015518
申请日：2007-07-06
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SON, Hyungbin , KONG, Jing , DASARI, Ramachandra , DRESSELHAUS, Mildred
Inventor： SON, Hyungbin , KONG, Jing , DASARI, Ramachandra , DRESSELHAUS, Mildred
CPC classification number: G02B6/34 , G01J3/02 , G01J3/021 , G01J3/06 , G01J3/1804 , G01J3/22 , G02B5/1828 , G02B5/1866 , G02B27/4244 , H01S3/1055 , H01S3/213 , H01S5/141
Abstract: A tunable transmissive grating comprises a transmissive dispersive element, a reflective element/ and an angle θ formed between the two elements. A first optical path is formed according to the angle θ, wherein light dispersing from the dispersive element is directed onto the reflective element and reflects therefrom. At least one element is rotatable about a rotational center to cause a second optical path and thereby tune the wavelength of the light reflecting from the reflective element. Both elements can be rotatable together around a common rotational center point according to certain embodiments, and/or each element can be independently rotated around a rotational axis associated only with that element. According to some embodiments, the relative angle θ formed between the elements is held constant; however, in other embodiments θ can vary. A control system can be used to operate the device.
Abstract translation: 可调透射光栅包括透射色散元件，反射元件和/ 形成在两个元素之间。 根据角度θ形成第一光路，其中从分散元件分散的光被引导到反射元件上并从其反射。 至少一个元件可围绕旋转中心旋转以产生第二光路，从而调谐从反射元件反射的光的波长。 根据某些实施例，两个元件可围绕公共旋转中心点一起旋转，和/或每个元件可以围绕仅与该元件相关联的旋转轴独立地旋转。 根据一些实施例，相对角度θ 在元件之间形成保持不变; 然而，在其他实施例中 可以有所不同 控制系统可用于操作设备。
-
公开(公告)号：WO2007014213A3
公开(公告)日：2007-02-01
申请号：PCT/US2006/028834
申请日：2006-07-25
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , YU, Chung-Chieh , LAU, Condon , FULGHUM, Stephen , FANG-YEN, Christopher , DASARI, Ramachandra , FELD, Michael, S.
Inventor： YU, Chung-Chieh , LAU, Condon , FULGHUM, Stephen , FANG-YEN, Christopher , DASARI, Ramachandra , FELD, Michael, S.
Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
-
公开(公告)号：WO2006104899A9
公开(公告)日：2006-12-14
申请号：PCT/US2006010821
申请日：2006-03-24
Applicant: MASSACHUSETTS INST TECHNOLOGY , POPESCU GABRIEL , DASARI RAMACHANDRA , FELD MICHAEL , IKEDA TAKAHIRO
Inventor： POPESCU GABRIEL , DASARI RAMACHANDRA , FELD MICHAEL , IKEDA TAKAHIRO
IPC: G01N21/45
CPC classification number: H01L27/14601 , G01N15/10 , G01N15/1475 , G01N21/453 , G01N33/49 , G01N2015/0073 , G01N2015/008 , G01N2015/145 , G01N2015/1454 , G01N2015/1497 , G06K9/00134
Abstract: Hubert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron- size water droplets.
Abstract translation: Hubert相位显微镜（HPM）作为用于测量与光学透明物体相关的高横向分辨率定量相位图像的光学技术。 由于其单一性质，HPM适用于调查在诸如生物细胞的透明结构中发生的快速现象。 优选实施例用于测量生物系统，包括对红细胞的测量，而其例如在毫秒级上量化动态过程的能力可以用蒸发微米级水滴的测量来说明。
-
公开(公告)号：WO2006104899A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/010821
申请日：2006-03-24
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY , POPESCU, Gabriel , DASARI, Ramachandra , FELD, Michael , IKEDA, Takahiro
Inventor： POPESCU, Gabriel , DASARI, Ramachandra , FELD, Michael , IKEDA, Takahiro
IPC: G01N21/45
CPC classification number: H01L27/14601 , G01N15/10 , G01N15/1475 , G01N21/453 , G01N33/49 , G01N2015/0073 , G01N2015/008 , G01N2015/145 , G01N2015/1454 , G01N2015/1497 , G06K9/00134
Abstract: Hubert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron- size water droplets.
Abstract translation: 作为用于测量与光学透明物体相关联的高横向分辨率定量相位图像的光学技术的休伯特相位显微镜（HPM）。 由于其单发性质，HPM适用于研究在生物细胞等透明结构中发生的快速现象。 一个优选的实施方案用于测量生物系统，包括红血球的测量结果，例如，它可以量化毫秒级的动态过程的能力，例如可以通过蒸发微米尺寸水滴的测量来说明。
-
-
-
-
-
-
-
-
-
Search Results
22
records
(took 0.025 seconds)
