公开(公告)号：WO2010006610A1

公开(公告)日：2010-01-21

申请号：PCT/DK2009/000174

申请日：2009-07-14

Applicant: DIRAMO A/S ,  CEQUR APS ,  PAASCH, Kasper ,  GRAVESEN, Peter

Inventor： PAASCH, Kasper

IPC: G01F17/00 ,  G01F22/02

CPC classification number: G01F23/14 ,  G01F22/02 ,  G01F23/18

Abstract: A system (1) and a method for determining a residual volume of a container unit (2) is disclosed. The system (1) comprises a container unit (2) comprising at least a primary container (3), means for applying a pressure inside the primary container (3), a flow restrictor (14) fluidly connected between the primary container (3) and the exterior of the container unit (2), means (P1, P3) for measuring a rate of pressure change of a pressure of the container unit (2), and means for determining a residual volume of the container unit (2) based on a measured rate of pressure change. The pressure inside the primary container (3) is allowed to adapt to the pressure of the exterior position in a controlled manner via the flow restrictor (14). Knowing the initial pressure in the primary container (3), and the flow resistance of the flow restrictor (14) the rate of pressure change is defined by the volume of the primary container (3), and this volume can thereby be determined. The volume of the primary container (3) thus determined may be the residual volume. Alternatively, the volume of the primary container (3) may be used for deriving another residual volume of the container unit (2).

Abstract translation: 公开了一种用于确定容器单元（2）的剩余容积的系统（1）和方法。 系统（1）包括容器单元（2），该容器单元至少包括主容器（3），用于在主容器（3）内施加压力的装置，流体连接在主容器（3）之间的流量限制器 和容器单元（2）的外部，用于测量容器单元（2）的压力变化率的装置（P1，P3）和用于确定容器单元（2）的剩余容积的装置 测量压力变化率。 允许主容器（3）内的压力通过限流器（14）以受控的方式适应外部位置的压力。 了解初级容器（3）中的初始压力和流量限制器（14）的流动阻力，压力变化率由初级容器（3）的体积确定，从而可以确定该体积。 如此确定的主容器（3）的体积可以是剩余体积。 或者，主容器（3）的体积可以用于导出容器单元（2）的另一剩余容积。

公开(公告)号：WO2010040354A1

公开(公告)日：2010-04-15

申请号：PCT/DK2009/000217

申请日：2009-10-07

Applicant: DIRAMO A/S ,  POULSEN, Kristian, Raaby ,  RASMUSSEN, Peter, Andreas

Inventor： POULSEN, Kristian, Raaby ,  RASMUSSEN, Peter, Andreas

IPC: F16K99/00 ,  B01L3/00 ,  B81B1/00

CPC classification number: F16K99/0001 ,  B01L2400/0633 ,  B81B2201/054 ,  B81C1/00119 ,  F16K99/0021 ,  Y10T29/494

Abstract: A method of forming a flow restriction in a fluid communication system is disclosed. The method comprises the steps of providing a flow restricting section having a cross sectional area and a length, measuring the flow resistivity of the flow restricting section, and modifying the cross sectional area and/or the length of the flow restricting section until a desired flow resistivity of the flow restricting section is obtained. The method provides the possibility of forming a flow restriction in an easy and cost effective manner, and to subsequently adjust the flow resistivity of the flow restriction, thereby obtaining an accurate flow resistivity.

Abstract translation: 公开了一种在流体通信系统中形成流量限制的方法。 该方法包括以下步骤：提供具有横截面面积和长度的流量限制部分，测量流动限制部分的流动阻力，以及修改流动限制部分的横截面面积和/或长度，直到所需流动 获得流量限制部分的电阻率。 该方法提供了以容易且成本有效的方式形成流动限制的可能性，并且随后调节流动限制的流动阻力，从而获得精确的流动阻力。

公开(公告)号：WO2009095020A1

公开(公告)日：2009-08-06

申请号：PCT/DK2009/000023

申请日：2009-01-30

Applicant: DIRAMO A/S ,  TRÖSKEN, Volker ,  STENSTRØM, Theiss ,  DIRAC, Holger

Inventor： TRÖSKEN, Volker ,  STENSTRØM, Theiss ,  DIRAC, Holger

IPC: A61B5/00 ,  A61M25/00 ,  B01D61/28

CPC classification number: A61M25/0026 ,  A61B5/145 ,  A61B5/14528 ,  B01D61/28 ,  B01D63/005 ,  B01D63/06 ,  B01D63/061

Abstract: A method of making a micro-dialysis probe (6) by providing a first flow channel (4), a second flow channel (5) and a separating wall (3) arranged in such a manner that it separates the first flow channel (4) and the second flow channel (5). The method further comprises providing at least one opening (7) in an outer wall (2) of the first (4) or second (5) flow channel, and arranging a semi-permeable membrane tube (8) therein. Finally, the method comprises removing material from the separating wall (3), thereby providing a communication opening (9) providing fluid communication between the first flow channel (4) and the second flow channel (5). The method is very easy to perform, and it is suitable for mass production. The invention further relates to a micro-dialysis probe (6).

Abstract translation: 一种通过提供第一流动通道（4），第二流动通道（5）和分隔壁（3）来制造微量透析探针（6）的方法，其以这样一种方式排列，即，将第一流动通道（4） ）和第二流动通道（5）。 该方法还包括在第一（4）或第二（5）流动通道的外壁（2）中提供至少一个开口（7），并在其中设置半透膜隔离管（8）。 最后，该方法包括从分离壁（3）中移除材料，从而提供在第一流动通道（4）和第二流动通道（5）之间提供流体连通的连通开口（9）。 该方法非常容易实现，适合批量生产。 本发明还涉及微透析探针（6）。

公开(公告)号：EP2107885A1

公开(公告)日：2009-10-14

申请号：EP08700904.9

申请日：2008-01-25

Applicant: Diramo A/S

Inventor： DIRAC, Holger ,  NIELSEN, Karsten, Dupont ,  RADMER, Jim ,  WINDUM, Jesper, Peter ,  AHM, Thorkild

IPC: A61B5/00

CPC classification number: A61B5/14503 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/1459

Abstract: A system for analysing a fluid, the system comprising a base station, an analysing unit being remote from the base station, and a substance collecting device being remote both from the base station and from the analysing unit, a first fluid communication link for communicating fluid between the base station and the analysing unit, and a second fluid communication link for communicating fluid between the analysing unit and the substance collecting device, wherein the analysing unit comprises sensing means adapted to provide data representing a content of a substance in the fluid and wherein the base station comprises data processing means being adapted to process the data to provide information regarding the content of the substance in the fluid.

Abstract translation: 一种用于分析流体的系统，所述系统包括基站，远离所述基站的分析单元和远离所述基站和所述分析单元的物质收集装置，用于连通流体的第一流体连通链路 以及用于在所述分析单元和所述物质收集装置之间连通流体的第二流体连通链路，其中所述分析单元包括适于提供表示流体中物质含量的数据的感测装置，其中， 基站包括数据处理装置，其适于处理数据以提供关于流体中的物质的内容的信息。

公开(公告)号：EP2117710A1

公开(公告)日：2009-11-18

申请号：EP07702462.8

申请日：2007-01-30

Applicant: Diramo A/S

Inventor： RASMUSSEN, Per Brandt ,  GRAVESEN, Peter

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01J2219/0081 ,  B01L3/565 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  Y10T137/8593

Abstract: The invention provides a micro fluid device comprising a substrate with a channel forming a receiving cavity, an outer chamber, and an inner chamber, the device further comprising a multi lumen hose with a free end portion which is fixed in the receiving cavity. The multi lumen hose forming a first conduit and at least one second conduit located radially offset from the first conduit, and the outer chamber is in fluid communication with at least one second conduit, and the inner chamber is in fluid communication with the first conduit. The chambers are separated by an inner sealing member located between the substrate and the hose. To simplify the manufacturing of the device, the channel is formed by a groove in an upper surface of a body of the substrate, which groove closed by an essentially plane cover which is sealed to the upper surface.

公开(公告)号：EP2043948A1

公开(公告)日：2009-04-08

申请号：EP07764488.8

申请日：2007-07-14

Applicant: CeQur ApS ,  Diramo A/S

Inventor： SCHWEITZ, Kasper Oktavio ,  MANSCHER, Martin

IPC: B81B1/00 ,  B01D19/00

CPC classification number: B81B1/002 ,  B81B2201/058 ,  Y10T137/8593 ,  Y10T137/9247

Abstract: A flow system, preferably a micro fluidic system, having a base part (4) with at least one flow path formed therein and a lid part (5) being attached to the base part (4) in such a manner that it covers the flow path(s). The flow path(s) comprise(s) a flow restrictor (1) and a flow channel comprising an inlet section positioned immediately upstream relatively to the flow restrictor (1). At least the inlet section of the flow channel has a cross section defining at least two distinct depths of the flow channel. This may be achieved by defining a centre section (3) and at least one peripheral section (2), the centre section (3) having a depth and a width which are substantially larger than the depth(s) and width(s) of the peripheral section(s) (2). If air bubbles are formed in the system this design of the inlet section will allow a flow of liquid to enter the shallower parts of the flow channel, while the air bubbles are confined to the deeper parts of the flow channel. Thereby air bubbles are prevented from entering the flow restrictor (1), thereby reducing the risk of air bubbles blocking the flow path through the flow restrictor (1). Simultaneously liquid is allowed to flow into the flow restrictor (1) substantially unaffected by the air bubble. Accordingly the flow system operates in a very reliable manner.