Abstract:
Methods are provided for producing T cell receptor (TCR) like antibodies that recognize peptides displayed in the context of HLA molecules. Antibodies produced by methods provided herein have the specificity of a TCR and can be used as therapeutic, diagnostic and research reagents. Also provided are TCR-like antibodies which recognize Epstein-Barr virus (EBV) peptides displayed in the context of HLA molecules and are useful for the detection and treatment of EBV and EBV-linked diseases.
Abstract:
An apparatus for generating laser radiation, the apparatus comprising: a pumping device comprising a resonant cavity; and a laser radiation generation element that is substantially Poynting vector walk-off compensated, the laser radiation generation element being located within the resonant cavity.
Abstract:
A method of determining the angle of arrival of a signal, the method comprising the steps of: providing a plurality of antennae; sampling, in turn, the output from each of the antennae, to obtain a set of samples, each of the samples relating to different points in time; performing a Fourier transform on the set of samples, thereby producing a sequence of spectral lines; identifying a signal impinging on the antennae from the configuration of the spectral lines; and calculating, from phase and amplitude data gathered from at least a subset of the spectral lines, the direction of arrival of the signal at the antennae. The invention allows high resolution estimation of the directions of arrival of multiple signals with a single channel receiver employing a plurality of antennae which may be spatially separated or provided in substantially the same location as one another. The antenna sampling rate need only be 2N times the bandwidth of the impinging signals (N being the number of antennae), and direction finders operating in accordance with the invention may be inexpensive, compact and high-performance.
Abstract:
A sensor member for use in a wearable device for monitoring vital signs of a user, the sensor member comprising: a substrate repeatedly extendable and retractable in a direction of extension/retraction, the direction of extension/retraction lying in a plane of the substrate; a deformation member disposed on the substrate; and an optical fibre attached to the substrate and including a bend, the bend lying in a plane that is non-coincident with the plane of the substrate, wherein the deformation member is disposed between the bend and substrate so that extension and retraction of the substrate changes a radius of curvature of the bend about the deformation member thereby modulating a signal propagated along the optical fibre.
Abstract:
Various embodiments provide a method for landing an unmanned aerial vehicle (UAV) (2) in the presence of a wind. The method comprises: performing a first flare- maneuver whilst the UAV is flying. The flare-maneuver causes a front portion of the UAV to rise with respect to a rear portion of the UAV (202). The method also comprises steering the UAV along a path heading into a direction of the wind (204). The method further comprises performing a second flare- maneuver before the UAV impacts a landing surface to land (206). Various embodiments provide a corresponding UAV.
Abstract:
An optical device adapted to transmit light from an area of interest to a field of view of a camera detector array of a camera, comprising at least two wedges, each wedge having a top wall, a bottom; wall, a front wall adapted to receive light from a segment of the area of interest, and a rear wall, wherein each of the at least two wedges is adapted to transmit the light from the segment to a corresponding segment of the field of view of the camera detector array. The wedges comprise a first wedge and a second wedge, and the bottom wall of the first wedge contacts the top wall of the second wedge such that each wedge is vertically offset from each other corresponding wedge, and each segment is horizontally offset from each other segment.
Abstract:
Various embodiments provide a method for landing an unmanned aerial vehicle (UAV) in the presence of a wind. The method comprises: performing a first flare-maneuver whilst the UAV is flying. The flare-maneuver causes a front portion of the UAV to rise with respect to a rear portion of the UAV. The method also comprises steering the UAV along a path heading into a direction of the wind. The method further comprises performing a second flare-maneuver before the UAV impacts a landing surface to land. Various embodiments provide a corresponding UAV.
Abstract:
Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing monoclonal antibodies to Dengue virus isolated from EBV immortalized B cells derived from patients who have recovered from Dengue infection are disclosed. Methods are provided for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate, or prevent relapse from infection.
Abstract:
There is disclosed a three stage method for the preparation of ladder-like silicone polymers. The first stage comprises hydrolysis and polymerization of alkyltrialkoxylsilane-like monomers to give relatively low molecular weight prepolymers. The second stage comprises dehydrated condensation polymerization of the prepolymers to give high molecular weight polymers. The third stage comprises partial blocking of a proportion of the pendant SinullOH (silanol) groups with a pre-determined sub-stoichiometric amount of a blocking agent. Also disclosed are the prepolymers, polymers and partially blocked polymers so produced.
Abstract:
A device for producing laser radiation, the device comprising: an elongate sample of a quasi-three-level laser material; a source of pumping radiation; and a concentrator configured such that at least some of the pumping radiation emitted by the source of pumping radiation is concentrated by the concentrator and subsequently enters the sample through a side surface thereof.