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公开(公告)号：WO2014162299A3
公开(公告)日：2014-10-09
申请号：PCT/IB2014/060441
申请日：2014-04-04
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： RAPTAKIS, Emmanual , PAPANASTASIOU, Dimitris , KOUNADIS, Diamantis , LEKKAS, Alexander , ORFANOPOULOS, Ioannis
Abstract: An electrospray ionisation source for generating charged droplets of liquid entrained within a gas flow (109) within a vacuum chamber (107), comprising a liquid insertion capillary (105) for receiving a liquid external to the vacuum chamber and for outputting the received liquid at an output end of the liquid insertion capillary within the vacuum chamber thereby to insert the liquid into the vacuum chamber. A nebuliser part (102, 103) comprises one or more gas flow ducts (103) for receiving a gas (108) external to the vacuum chamber and for outputting the received gas at an output end (110) of the nebuliser part comprising output end(s) of the one or more said gas flow ducts within the vacuum chamber. This inserts a gas flow (109) into the vacuum chamber (107). A charger part (114, or 217) is provided for charging said droplets of said liquid output by said nebulizer part. The liquid insertion capillary is located within the output end of the nebuliser part so as to position the output end of the liquid insertion capillary within gas flows output by the nebuliser part, in use, to entrain charged droplets of the inserted liquid within flows of the inserted gas.
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公开(公告)号：US20220344144A1
公开(公告)日：2022-10-27
申请号：US17723501
申请日：2022-04-19
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： DIMITRIS PAPANASTASIOU
Abstract: An apparatus (100, 300, 700) is described, comprising: a linear ion trap (102) comprising two pairs of pole electrodes and a radiofrequency, RF, electrical potential supply (117) configured to apply respective RF waveforms to the pairs of pole electrodes, thereby forming a RF trapping field component to trap analyte ions (116) radially in a trapping region (115) of the linear ion trap for processing of the analyte ions (116) therein; a charged particle source (101) comprising a pulse valve (103), a conduit (106, 107), having an entrance in fluid communication therewith and an exit, wherein the conduit (106, 107) extends in the direction of the trapping region (115), and a discharge device (108) electrically coupled to an electrical potential supply (109) and disposed between the entrance and the exit of the conduit (106, 107), wherein the pulse valve (103) is configured to release a gas pulse from a gas supply into the entrance of the conduit (106, 107) and wherein the electrical potential supply (109) is configured to apply a high voltage to the discharge device (108) to generate a discharge (110) in the gas pulse in the conduit (106, 107), thereby generating charged particles (114) from the gas and accelerating the generated charged particles in the direction of the trapping region (115). A method is also described.
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公开(公告)号：US20160049285A1
公开(公告)日：2016-02-18
申请号：US14781618
申请日：2014-04-04
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： DIMITRIS PAPANASTASIOU , EMMANUEL RAPTAKIS , DIAMANTIS KOUNADIS , ALEXANDER LEKKAS , IOANNIS ORFANOPOULOS
CPC classification number: H01J49/167 , H01J49/0404 , H01J49/045 , H01J49/0495 , H01J49/162
Abstract: Techniques are provided for generating charged droplets of liquid entrained within a gas flow within a vacuum chamber and for controlling the gas flow. The gas flow with the entrained charged droplets of liquid is jetted into the vacuum chamber along a predetermined jetting axis. The gas jet is received within a gas conduit housed within the vacuum chamber and having a conduit bore coaxial with the predetermined jetting axis. The received gas jet is caused to be restrained to form a laminar gas flow entrained with charged droplets inside of the gas conduit for guiding the entrained charged droplets therealong.
Abstract translation: 提供了技术来产生夹带在真空室内的气流中的带电液滴并用于控制气流。 具有夹带的液体的带电液滴的气流沿着预定的喷射轴线被喷射到真空室中。 气体射流被容纳在容纳在真空室内的气体管道中，并且具有与预定喷射轴线同轴的导管孔。 引起接收的气体射流被限制以形成夹带在气体导管内部的带电荷的液滴的层流气流，用于在其上引导夹带的带电液滴。
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公开(公告)号：WO2014162299A2
公开(公告)日：2014-10-09
申请号：PCT/IB2014060441
申请日：2014-04-04
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： RAPTAKIS EMMANUAL , PAPANASTASIOU DIMITRIS , KOUNADIS DIAMANTIS , LEKKAS ALEXANDER , ORFANOPOULOS IOANNIS
CPC classification number: H01J49/167 , H01J49/0404 , H01J49/045 , H01J49/0495 , H01J49/162
Abstract: An electrospray ionisation source for generating charged droplets of liquid entrained within a gas flow (109) within a vacuum chamber (107), comprising a liquid insertion capillary (105) for receiving a liquid external to the vacuum chamber and for outputting the received liquid at an output end of the liquid insertion capillary within the vacuum chamber thereby to insert the liquid into the vacuum chamber. A nebuliser part (102, 103) comprises one or more gas flow ducts (103) for receiving a gas (108) external to the vacuum chamber and for outputting the received gas at an output end (1 10) of the nebuliser part comprising output end(s) of the one or more said gas flow ducts within the vacuum chamber. This inserts a gas flow (109) into the vacuum chamber 107). A charger part (1 14, or 217) is provided for charging said droplets of said liquid output by said nebulizer part. The liquid insertion capillary is located within the output end of the nebuliser part so as to position the output end of the liquid insertion capillary within gas flows output by the nebuliser part, in use, to entrain charged droplets of the inserted liquid within flows of the inserted gas.
Abstract translation: 一种电喷雾离子源，用于产生夹带在真空室（107）内的气流（109）内的液体的带电液滴，包括用于接收真空室外部的液体的液体插入毛细管（105），并将所接收的液体输出 真空室内的液体插入毛细管的输出端，从而将液体插入真空室。 雾化器部分（102,103）包括用于接收真空室外部的气体（108）的一个或多个气体流动管道（103），并且用于在雾化器部分的输出端（110）输出接收的气体，包括输出 真空室内的一个或多个所述气体流动管道的端部。 这将气流（109）插入真空室107）。 提供充电器部件（114或217），用于对由所述喷雾器部分输出的所述液体的液滴进行充电。 液体插入毛细管位于雾化器部分的输出端内，以便将液体插入毛细管的输出端定位在雾化器部分输出的气体流中，以在使用中将插入的液体的带电液滴夹在 插入气体。
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公开(公告)号：WO2011148312A3
公开(公告)日：2011-12-01
申请号：PCT/IB2011/052244
申请日：2011-05-23
Inventor： RAPTAKIS, Emmanuel , PAPANASTASIOU, Dimitris
IPC: H01J49/06
Abstract: A mass spectrometer comprises ion pulse means for producing ion pulses in a first vacuum chamber, ion trap means for receiving and trapping the ion pulses for mass analysis in a second vacuum chamber, and ion-optical lens means arranged between the ion pulse means and the ion trap means for receiving the ion pulses and outputting ions therefrom to the ion trap means. A first lens electrode and a second lens electrode collectively define an optical axis and are adapted for distributing a first electrical potential and second electrical potential therealong. Lens control means vary non-periodically with time the first electrical potential relative to the second electrical potential to control as a function of ion mass-to-charge ratio the kinetic energy of ions which have traversed the ion optical lens means. This controls the mass range of the ions receivable by the ion trap from the ion optical lens means.
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Patent Agency Ranking
公开(公告)号：US12009197B2
公开(公告)日：2024-06-11
申请号：US17723501
申请日：2022-04-19
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： Dimitris Papanastasiou
CPC classification number: H01J49/4225 , H01J49/022
Abstract: An apparatus includes a linear ion trap and a charged particle source coupled to one another in a vacuum housing. The linear ion trap has a longitudinal axis and a trapping region configured to store analyte ions. The charged particle source has a conduit, a pulse valve, and a discharge device. The conduit extends towards the trapping region in a direction perpendicular to the longitudinal axis of the linear ion trap and has an entrance and an exit. The pulse valve is disposed in fluid communication with the conduit and is configured to release a gas pulse from a gas supply into the entrance of the conduit. The discharge device is electrically coupled to an electrical potential supply and disposed between the entrance and the exit of the conduit. The electrical potential supply is configured to apply a high voltage to the discharge device to generate a discharge in the gas pulse in the conduit, thereby generating charged particles from the gas and accelerating the generated charged particles towards the trapping region in the direction perpendicular to the longitudinal axis of the linear ion trap to activate analyte ions stored in the trapping region.
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公开(公告)号：GB2508574A
公开(公告)日：2014-06-11
申请号：GB201211186
申请日：2012-06-24
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： RAPTAKIS EMMANUEL , PAPANASTASIOU DIMITRIS , KOUNADIS DIAMANTIS , LEKKAS ALEXANDER , ORFANOPOULOS IOANNIS , NIKOLOS IOANNIS K
IPC: H01J49/04
Abstract: A guide apparatus for generating a flow of ions comprises an ion source 61 for providing ions within a gas at a source pressure. A vacuum chamber 63 is controllable to achieve a second pressure therein and comprises a gas inlet 62 having a first cross sectional area (a) arranged for jetting said gas containing entrained ions into the vacuum chamber along a predetermined jetting axis. A gas duct 67 comprising a duct bore having a second cross sectional area (A) is positioned coaxially with the jetting axis, in register with the gas inlet opening. The second pressure is controlled so as to form a supersonic free jet in the duct with a jet pressure ratio restrained to a value which does not exceed the cubed ratio (A/a)3 of the second and first cross sectional areas. As a result, the expansion of the free jet is restrained so as to form a subsonic laminar flow 71 within the gas duct for guiding entrained ions.
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公开(公告)号：GB201306114D0
公开(公告)日：2013-05-22
申请号：GB201306114
申请日：2013-04-04
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
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公开(公告)号：GB2502155A
公开(公告)日：2013-11-20
申请号：GB201208849
申请日：2012-05-18
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： RAPTAKIS EMMANUEL , PAPANASTASIOU DIMITRIS
Abstract: An ion guide comprises at least two sets of parallel elongate rods disposed circumferentially about a common axis, and to each set is applied independently a RF potential generating a multipole electric field and a DC potential. The order of the multipole field applied decreases from the highest order applied to the set of rods at the entrance end to the lowest order applied to the set of rods at the exit end. The order of each set can equal the number of rods and there can be a third set of rods. The sets can operate as dodecapole, hexapole, octapole or quadrapole ion guides. There can be a series of parallel rod segments about a common axis (fig 3) supplied with an RF potential to form a multipole field confining ions radially and a DC potential forming a field gradient to manipulate the ions axially, the order of multipole field decreasing progressively from a higher order at the entrance to a lower order at the exit to radially compress the ion beam. The hybrid ion guide can operate in a continuous mode using RF voltages to generate mulitpole fields and DC gradients along the axis (cooling mode) or by superimposing periodic pulses for trapping and releasing ions regions of different field-order (bunching mode). The device can be used as a collision cell in either mode or can be coupled to orthogonal TOF mass analyzers to enhance duty cycle.
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公开(公告)号：GB2508574B
公开(公告)日：2014-12-17
申请号：GB201211186
申请日：2012-06-24
Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA
Inventor： RAPTAKIS EMMANUEL , PAPANASTASIOU DIMITRIS , KOUNADIS DIAMANTIS , LEKKAS ALEXANDER , ORFANOPOULOS IOANNIS , NIKOLOS IOANNIS K
IPC: H01J49/04
Abstract: A guide apparatus includes a vacuum compartment provided at a background pressure and having a gas inlet opening arranged for jetting a gas in the form of a free jet stream containing entrained ions into a vacuum chamber along a predetermined jetting axis. At least one duct housed within the vacuum chamber has a guide bore positioned coaxially with the jetting axis for receiving the free jet stream such that a supersonic free jet is formed in the duct with a jet pressure ratio P1/P2 restrained to a value that does not exceed (A/a)3 to form a subsonic laminar gas flow inside of the duct for guiding the entrained ions, where P1 is the pressure at an exit end of the gas inlet opening, P2 is the background pressure, A is the cross sectional area of the bore, and a is the cross sectional area of the gas inlet opening.
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