公开(公告)号：GB2508574A

公开(公告)日：2014-06-11

申请号：GB201211186

申请日：2012-06-24

Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA

Inventor： RAPTAKIS EMMANUEL ,  PAPANASTASIOU DIMITRIS ,  KOUNADIS DIAMANTIS ,  LEKKAS ALEXANDER ,  ORFANOPOULOS IOANNIS ,  NIKOLOS IOANNIS K

IPC: H01J49/04

Abstract: A guide apparatus for generating a flow of ions comprises an ion source 61 for providing ions within a gas at a source pressure. A vacuum chamber 63 is controllable to achieve a second pressure therein and comprises a gas inlet 62 having a first cross sectional area (a) arranged for jetting said gas containing entrained ions into the vacuum chamber along a predetermined jetting axis. A gas duct 67 comprising a duct bore having a second cross sectional area (A) is positioned coaxially with the jetting axis, in register with the gas inlet opening. The second pressure is controlled so as to form a supersonic free jet in the duct with a jet pressure ratio restrained to a value which does not exceed the cubed ratio (A/a)3 of the second and first cross sectional areas. As a result, the expansion of the free jet is restrained so as to form a subsonic laminar flow 71 within the gas duct for guiding entrained ions.

公开(公告)号：WO2014162299A2

公开(公告)日：2014-10-09

申请号：PCT/IB2014060441

申请日：2014-04-04

Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA

Inventor： RAPTAKIS EMMANUAL ,  PAPANASTASIOU DIMITRIS ,  KOUNADIS DIAMANTIS ,  LEKKAS ALEXANDER ,  ORFANOPOULOS IOANNIS

CPC classification number: H01J49/167 ,  H01J49/0404 ,  H01J49/045 ,  H01J49/0495 ,  H01J49/162

Abstract: An electrospray ionisation source for generating charged droplets of liquid entrained within a gas flow (109) within a vacuum chamber (107), comprising a liquid insertion capillary (105) for receiving a liquid external to the vacuum chamber and for outputting the received liquid at an output end of the liquid insertion capillary within the vacuum chamber thereby to insert the liquid into the vacuum chamber. A nebuliser part (102, 103) comprises one or more gas flow ducts (103) for receiving a gas (108) external to the vacuum chamber and for outputting the received gas at an output end (1 10) of the nebuliser part comprising output end(s) of the one or more said gas flow ducts within the vacuum chamber. This inserts a gas flow (109) into the vacuum chamber 107). A charger part (1 14, or 217) is provided for charging said droplets of said liquid output by said nebulizer part. The liquid insertion capillary is located within the output end of the nebuliser part so as to position the output end of the liquid insertion capillary within gas flows output by the nebuliser part, in use, to entrain charged droplets of the inserted liquid within flows of the inserted gas.

Abstract translation: 一种电喷雾离子源，用于产生夹带在真空室（107）内的气流（109）内的液体的带电液滴，包括用于接收真空室外部的液体的液体插入毛细管（105），并将所接收的液体输出 真空室内的液体插入毛细管的输出端，从而将液体插入真空室。 雾化器部分（102,103）包括用于接收真空室外部的气体（108）的一个或多个气体流动管道（103），并且用于在雾化器部分的输出端（110）输出接收的气体，包括输出 真空室内的一个或多个所述气体流动管道的端部。 这将气流（109）插入真空室107）。 提供充电器部件（114或217），用于对由所述喷雾器部分输出的所述液体的液滴进行充电。 液体插入毛细管位于雾化器部分的输出端内，以便将液体插入毛细管的输出端定位在雾化器部分输出的气体流中，以在使用中将插入的液体的带电液滴夹在 插入气体。

公开(公告)号：GB2508574B

公开(公告)日：2014-12-17

申请号：GB201211186

申请日：2012-06-24

Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA

Inventor： RAPTAKIS EMMANUEL ,  PAPANASTASIOU DIMITRIS ,  KOUNADIS DIAMANTIS ,  LEKKAS ALEXANDER ,  ORFANOPOULOS IOANNIS ,  NIKOLOS IOANNIS K

IPC: H01J49/04

Abstract: A guide apparatus includes a vacuum compartment provided at a background pressure and having a gas inlet opening arranged for jetting a gas in the form of a free jet stream containing entrained ions into a vacuum chamber along a predetermined jetting axis. At least one duct housed within the vacuum chamber has a guide bore positioned coaxially with the jetting axis for receiving the free jet stream such that a supersonic free jet is formed in the duct with a jet pressure ratio P1/P2 restrained to a value that does not exceed (A/a)3 to form a subsonic laminar gas flow inside of the duct for guiding the entrained ions, where P1 is the pressure at an exit end of the gas inlet opening, P2 is the background pressure, A is the cross sectional area of the bore, and a is the cross sectional area of the gas inlet opening.

公开(公告)号：GB2512640A

公开(公告)日：2014-10-08

申请号：GB201306114

申请日：2013-04-04

Applicant: FASMATECH SCIENCE AND TECHNOLOGY SA

Inventor： RAPTAKIS EMMANUEL ,  PAPANASTASIOU DIMITRIS ,  KOUNADIS DIAMANTIS ,  LEKKAS ALEXANDER ,  ORFANOPOULOS IOANNIS

IPC: H01J49/16 ,  H01J49/04

Abstract: A nebulized fluid is formed by injecting a liquid comprising a solvent into a vacuum system 107connected to a mass analyzer directly at supersonic speeds. Liquid droplets are entrained within a gas stream 109 also injected into the vacuum system. The droplets are ionized by an electrode ring 217 although it is envisaged that non-charged droplets may be produced and ionized within an ion optics system. The solvent subsequently evaporates during transit through an ion optics system to provide a stream of ions to a mass analyzer. Secondary or primary ionization of the ions/molecules may be provided using a UV source arranged in the ion optics system. The droplets/ions produced by the nozzle are directly injected into the mass analyser vacuum system so differential vacuum pumping systems are not required. The nozzle configuration with direct injection into a vacuum enables reduced droplet sizes and increased droplet dispersion that enhances desolvation whilst at the same time allowing high flow rates. Also, the ion optics system provided converts the supersonic jet injected into the system into a subsonic laminar flow of ions, and because the ion flow is laminar the loss of ions in the ion-optics system is reduced.