Abstract:
An electrospray ionisation source for generating charged droplets of liquid entrained within a gas flow (109) within a vacuum chamber (107), comprising a liquid insertion capillary (105) for receiving a liquid external to the vacuum chamber and for outputting the received liquid at an output end of the liquid insertion capillary within the vacuum chamber thereby to insert the liquid into the vacuum chamber. A nebuliser part (102, 103) comprises one or more gas flow ducts (103) for receiving a gas (108) external to the vacuum chamber and for outputting the received gas at an output end (1 10) of the nebuliser part comprising output end(s) of the one or more said gas flow ducts within the vacuum chamber. This inserts a gas flow (109) into the vacuum chamber 107). A charger part (1 14, or 217) is provided for charging said droplets of said liquid output by said nebulizer part. The liquid insertion capillary is located within the output end of the nebuliser part so as to position the output end of the liquid insertion capillary within gas flows output by the nebuliser part, in use, to entrain charged droplets of the inserted liquid within flows of the inserted gas.