公开(公告)号：CA2104838A1

公开(公告)日：1994-02-28

申请号：CA2104838

申请日：1993-08-25

Applicant: GOLDBERG STEVEN L ,  JOHNSTON ROBERT M ,  CINO PAUL M

Inventor： GOLDBERG STEVEN L ,  JOHNSTON ROBERT M ,  CINO PAUL M

IPC: C12N1/21 ,  C12N9/20 ,  C12N15/09 ,  C12N15/55 ,  C12P21/02 ,  C12R1/19

Abstract: PSEUDOMONAS LIPASE Nucleic acid sequences, particularly DNA sequences, coding for all or part of a lipase of Pseudomonas sp. ATCC 21808, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the SacI/HindIII insert of plasmid pSG312 deposited with the American Type Culture Collection, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a lipase of Pseudomonas sp. ATCC 21808, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the SacI/HindIII insert of plasmid pSG312 deposited with the American Type Culture Collection, and methods for producing these polypeptides molecules.

公开(公告)号：CA232795A

公开(公告)日：1923-07-17

申请号：CA232795D

Applicant: JOHNSTON ROBERT M

Inventor： JOHNSTON ROBERT M

公开(公告)号：CA189381A

公开(公告)日：1919-04-01

申请号：CA189381D

申请日：1917-01-27

Applicant: JOHNSTON ROBERT M

Inventor： JOHNSTON ROBERT M

公开(公告)号：CA126627A

公开(公告)日：1910-06-28

申请号：CA126627D

申请日：1909-08-23

Applicant: JOHNSTON ROBERT M

Inventor： JOHNSTON ROBERT M

公开(公告)号：WO2012106579A1

公开(公告)日：2012-08-09

申请号：PCT/US2012/023740

申请日：2012-02-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  GOSWAMI, Animesh ,  GOLDBERG, Steven L. ,  JOHNSTON, Robert M. ,  HANSON, Ronald L. ,  PARKER, William Lawrence

Inventor： GOSWAMI, Animesh ,  GOLDBERG, Steven L. ,  JOHNSTON, Robert M. ,  HANSON, Ronald L. ,  PARKER, William Lawrence

IPC: C07K14/435 ,  C12N9/04 ,  C12P13/04

CPC classification number: C12Y104/01 ,  C12N9/0016 ,  C12P13/005 ,  C12P13/04

Abstract: The instant invention provides a novel amino acid dehydrogenase can be utilized to convert keto acids to amino acids more efficiently and in a more cost effective manner. The instant invention also provides knock-out cells which lack glutamate dehydrogenase.

Abstract translation: 本发明提供了一种新的氨基酸脱氢酶，其可以更有效地并以更具成本效益的方式将酮酸转化为氨基酸。 本发明还提供缺乏谷氨酸脱氢酶的敲除细胞。

公开(公告)号：WO2003057393A1

公开(公告)日：2003-07-17

申请号：PCT/US2002/041749

申请日：2002-12-31

Applicant: GOULD ELECTRONICS INC. ,  JOHNSTON, Robert, M.

Inventor： JOHNSTON, Robert, M.

IPC: B23B35/00

CPC classification number: B23B35/00 ,  B23B2250/12 ,  D06M13/17 ,  D06M2200/40 ,  D21H17/53 ,  H05K3/0047 ,  H05K2201/0116 ,  H05K2201/029 ,  H05K2203/0786 ,  H05K2203/127 ,  Y10T408/03

Abstract: A lubricant sheet (10) for use in drilling holes in a printed circuit board, including a lubricant layer. The lubricant layer includes at least a water-soluble lubricant. In an alternative embodiment, the lubricant layer also includes an inversely-soluble lubricant. The water-soluble lubricant is preferably polyethylene glycol (14), having a weight average molecular weight between about 4,500 and 7,000. The inversely-soluble lubricant is preferably polyalkylene glycol (14). The lubricant sheet (10) may also include a porous, fibrous, organic sheet impreganted with lubricant and/or a polymer-impregnated paper.

Abstract translation: 一种用于在包括润滑剂层的印刷电路板中钻孔的润滑剂片（10）。 润滑剂层至少包含水溶性润滑剂。 在替代实施例中，润滑剂层还包括反溶性润滑剂。 水溶性润滑剂优选为聚乙二醇（14），其重均分子量约为4,500-7,000。 反溶剂润滑剂优选为聚亚烷基二醇（14）。 润滑剂片（10）还可以包括多孔的，纤维状的，有润滑剂和/或聚合物浸渍纸的有机片。

公开(公告)号：WO2003054155A3

公开(公告)日：2003-07-03

申请号：PCT/US2002/040235

申请日：2002-12-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  GOLDBERG, Steven, L. ,  CINO, Paul, M. ,  PATEL, Ramesh, N. ,  NANDURI, Venkata, B. ,  JOHNSTON, Robert, M.

Inventor： GOLDBERG, Steven, L. ,  CINO, Paul, M. ,  PATEL, Ramesh, N. ,  NANDURI, Venkata, B. ,  JOHNSTON, Robert, M.

IPC: C12N9/04

Abstract: This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

公开(公告)号：WO2005001047A2

公开(公告)日：2005-01-06

申请号：PCT/US2004/017457

申请日：2004-06-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  NANDURI, Venkata, B. ,  PATEL, Ramesh, N. ,  GOLDBERG, Steven, L. ,  JOHNSTON, Robert, M.

Inventor： NANDURI, Venkata, B. ,  PATEL, Ramesh, N. ,  GOLDBERG, Steven, L. ,  JOHNSTON, Robert, M.

IPC: C07H21/04

CPC classification number: C12N9/78

公开(公告)号：WO2005001047A8

公开(公告)日：2006-04-20

申请号：PCT/US2004017457

申请日：2004-06-03

Applicant: SQUIBB BRISTOL MYERS CO ,  NANDURI VENKATA B ,  PATEL RAMESH N ,  GOLDBERG STEVEN L ,  JOHNSTON ROBERT M

Inventor： NANDURI VENKATA B ,  PATEL RAMESH N ,  GOLDBERG STEVEN L ,  JOHNSTON ROBERT M

IPC: C12N20060101 ,  C07H21/04

CPC classification number: C12N9/78

公开(公告)号：WO2006130657A2

公开(公告)日：2006-12-07

申请号：PCT/US2006/021066

申请日：2006-05-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  PATEL, Ramesh, N. ,  CHU, Linda, Nga, Hoong ,  JOHNSTON, Robert, M. ,  GUO, Zhiwei ,  CHEN, Yijun ,  GOLDBERG, Steven, L. ,  HANSON, Ronald, L. ,  GOSWAMI, Animesh ,  KATIPALLY, Kishta

Inventor： PATEL, Ramesh, N. ,  CHU, Linda, Nga, Hoong ,  JOHNSTON, Robert, M. ,  GUO, Zhiwei ,  CHEN, Yijun ,  GOLDBERG, Steven, L. ,  HANSON, Ronald, L. ,  GOSWAMI, Animesh ,  KATIPALLY, Kishta

CPC classification number: C12N9/0006 ,  C07D487/04 ,  C12P17/165

Abstract: The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula (Ib).

Abstract translation: 本发明涉及一种用于酶促立体选择性还原酮化合物以提供手性醇的方法，例如式（Ib）的化合物。