公开(公告)号：EP1981851A1

公开(公告)日：2008-10-22

申请号：EP07762713.1

申请日：2007-01-26

Applicant: Array Biopharma, Inc. ,  Groneberg, Robert ,  Burgess, Laurence E. ,  Harvey, Darren ,  Laird, Ellen ,  Munson, Mark ,  Rizzi, James ,  Rodriguez, Martha ,  Eary, Charles Todd ,  Watson, Daniel

Inventor： GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

IPC: C07D231/40 ,  C07D231/56 ,  A61K31/416 ,  A61P29/00

CPC classification number: C07D231/40 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

公开(公告)号：EP1846391A2

公开(公告)日：2007-10-24

申请号：EP06734199.0

申请日：2006-02-02

Applicant: Genentech, Inc. ,  Array Biopharma, Inc. ,  Laird, Ellen ,  Lyssikatos, Joseph P. ,  Welch, Mike ,  Grina, Jonas ,  Hansen, Josh ,  Newhouse, Brad ,  Olivero, Alan ,  Topolav, George

Inventor： Genentech, Inc. ,  Array Biopharma, Inc. ,  Laird, Ellen ,  Lyssikatos, Joseph P. ,  Welch, Mike ,  Grina, Jonas ,  Hansen, Josh ,  Newhouse, Brad ,  Olivero, Alan ,  Topolav, George

IPC: C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/415 ,  A61P35/00 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P37/00 ,  A61P25/00

CPC classification number: C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D487/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：AU2006210626A1

公开(公告)日：2006-08-10

申请号：AU2006210626

申请日：2006-02-02

Applicant: OLIVERO ALAN ,  NEWHOUSE BRAD ,  LYSSIKATOS JPSEPH ,  ARRAY BIOPHARMA INC ,  TOPOLAV GEORGE ,  GENENTECH INC ,  WELCH MIKE ,  GRINA JONAS ,  LAIRD ELLEN ,  HANSEN JOSH

Inventor： TOPOLAV GEORGE ,  OLIVERO ALAN ,  LYSSIKATOS JOSEPH P ,  GRINA JONAS ,  NEWHOUSE BRAD ,  WELCH MIKE ,  HANSEN JOSH ,  LAIRD ELLEN

IPC: C07D401/04 ,  A61K31/415 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D471/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2009111279A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/035381

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体，互变异构体，前药和其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

公开(公告)号：WO2009111277A9

公开(公告)日：2009-09-11

申请号：PCT/US2009/035379

申请日：2009-02-27

Applicant: ARRAY BIOPHARMA INC. ,  GENENTECH, INC. ,  AHRENDT, Kateri, A. ,  BUCKMELTER, Alexandre, J. ,  GRINA, Jonas ,  HANSEN, Joshua, D. ,  LAIRD, Ellen, R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven, M. ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy, B. ,  MORENO, David, A.

Inventor： AHRENDT, Kateri, A. ,  BUCKMELTER, Alexandre, J. ,  GRINA, Jonas ,  HANSEN, Joshua, D. ,  LAIRD, Ellen, R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven, M. ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy, B. ,  MORENO, David, A.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P35/00 ,  A61P13/12

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2007089646A1

公开(公告)日：2007-08-09

申请号：PCT/US2007/002272

申请日：2007-01-26

Applicant: ARRAY BIOPHARMA INC. ,  GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

Inventor： GRONEBERG, Robert ,  BURGESS, Laurence, E. ,  HARVEY, Darren ,  LAIRD, Ellen ,  MUNSON, Mark ,  RIZZI, James ,  RODRIGUEZ, Martha ,  EARY, Charles, Todd ,  WATSON, Daniel

IPC: C07D231/40 ,  C07D231/56 ,  A61K31/416 ,  A61P29/00

CPC classification number: C07D231/40 ,  C07D231/56

Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.

Abstract translation: 式（I）化合物及其药学上可接受的盐和前药可用于治疗和预防由激酶介导的各种疾病。

公开(公告)号：WO2007027855A2

公开(公告)日：2007-03-08

申请号：PCT/US2006/033976

申请日：2006-08-31

Applicant: ARRAY BIOPHARMA INC. ,  MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐的方法用于在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些疾病。 披露。

公开(公告)号：WO2006125101A2

公开(公告)日：2006-11-23

申请号：PCT/US2006019280

申请日：2006-05-18

Applicant: ARRAY BIOPHARMA INC ,  LAIRD ELLEN ,  TOPALOV GEORGE ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD

Inventor： LAIRD ELLEN ,  TOPALOV GEORGE ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD

CPC classification number: C07D487/04

Abstract: Compounds of Formula (I) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式（I）的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 公开了使用式（I）化合物及其立体异构体，互变异构体，溶剂合物及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理学病症中的这种病症的方法 。

公开(公告)号：WO2006084015A3

公开(公告)日：2006-08-10

申请号：PCT/US2006/003654

申请日：2006-02-02

Applicant: GENENTECH, INC. ,  ARRAY BIOPHARMA, INC. ,  LAIRD, Ellen ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad ,  OLIVERO, Alan ,  TOPOLAV, George

Inventor： LAIRD, Ellen ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad ,  OLIVERO, Alan ,  TOPOLAV, George

IPC: C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/415 ,  A61P35/00 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P37/00 ,  A61P25/00

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2006084015A2

公开(公告)日：2006-08-10

申请号：PCT/US2006003654

申请日：2006-02-02

Applicant: GENENTECH INC ,  ARRAY BIOPHARMA INC ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD ,  OLIVERO ALAN ,  TOPOLAV GEORGE

Inventor： LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD ,  OLIVERO ALAN ,  TOPOLAV GEORGE

IPC: C07D401/04 ,  A61K31/415 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D471/04

CPC classification number: C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D487/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式Ia和Ib的吡唑基化合物可用于抑制Raf激酶并用于治疗由其介导的病症。 公开了使用吡唑基化合物体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。