公开(公告)号：EP1846391A2

公开(公告)日：2007-10-24

申请号：EP06734199.0

申请日：2006-02-02

Applicant: Genentech, Inc. ,  Array Biopharma, Inc. ,  Laird, Ellen ,  Lyssikatos, Joseph P. ,  Welch, Mike ,  Grina, Jonas ,  Hansen, Josh ,  Newhouse, Brad ,  Olivero, Alan ,  Topolav, George

Inventor： Genentech, Inc. ,  Array Biopharma, Inc. ,  Laird, Ellen ,  Lyssikatos, Joseph P. ,  Welch, Mike ,  Grina, Jonas ,  Hansen, Josh ,  Newhouse, Brad ,  Olivero, Alan ,  Topolav, George

IPC: C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/415 ,  A61P35/00 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P37/00 ,  A61P25/00

CPC classification number: C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D487/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2006084015A3

公开(公告)日：2006-08-10

申请号：PCT/US2006/003654

申请日：2006-02-02

Applicant: GENENTECH, INC. ,  ARRAY BIOPHARMA, INC. ,  LAIRD, Ellen ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad ,  OLIVERO, Alan ,  TOPOLAV, George

Inventor： LAIRD, Ellen ,  LYSSIKATOS, Joseph, P. ,  WELCH, Mike ,  GRINA, Jonas ,  HANSEN, Josh ,  NEWHOUSE, Brad ,  OLIVERO, Alan ,  TOPOLAV, George

IPC: C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/415 ,  A61P35/00 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P37/00 ,  A61P25/00

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：WO2006084015A2

公开(公告)日：2006-08-10

申请号：PCT/US2006003654

申请日：2006-02-02

Applicant: GENENTECH INC ,  ARRAY BIOPHARMA INC ,  LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD ,  OLIVERO ALAN ,  TOPOLAV GEORGE

Inventor： LAIRD ELLEN ,  LYSSIKATOS JOSEPH P ,  WELCH MIKE ,  GRINA JONAS ,  HANSEN JOSH ,  NEWHOUSE BRAD ,  OLIVERO ALAN ,  TOPOLAV GEORGE

IPC: C07D401/04 ,  A61K31/415 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D471/04

CPC classification number: C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D403/02 ,  C07D487/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式Ia和Ib的吡唑基化合物可用于抑制Raf激酶并用于治疗由其介导的病症。 公开了使用吡唑基化合物体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。

公开(公告)号：AU2006210626A1

公开(公告)日：2006-08-10

申请号：AU2006210626

申请日：2006-02-02

Applicant: OLIVERO ALAN ,  NEWHOUSE BRAD ,  LYSSIKATOS JPSEPH ,  ARRAY BIOPHARMA INC ,  TOPOLAV GEORGE ,  GENENTECH INC ,  WELCH MIKE ,  GRINA JONAS ,  LAIRD ELLEN ,  HANSEN JOSH

Inventor： TOPOLAV GEORGE ,  OLIVERO ALAN ,  LYSSIKATOS JOSEPH P ,  GRINA JONAS ,  NEWHOUSE BRAD ,  WELCH MIKE ,  HANSEN JOSH ,  LAIRD ELLEN

IPC: C07D401/04 ,  A61K31/415 ,  A61P3/10 ,  A61P9/00 ,  A61P17/06 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/14 ,  C07D471/04

Abstract: Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.