Abstract:
A triggered release liposomal delivery system is disclosed that selectively releases its contents in response to illumination or reduction in pH. The liposomes contain an amphipathic lipid, such as a phospholipid, having two chains derived from fatty acid that allow the lipid to pack into a bilayer structure. One or both of the alkyl chains contains a vinyl ether functionality that is cleaved by reactive oxygen species (ROS) or acid. A photosensitizer is incorporated into the liposomal cavity or membrane, and produces ROS or acid when illuminated to cleave the vinyl ether functionality and disrupt the liposomal membrane to release the vesicle contents. The lipid is preferably a plasmalogen, for example (* CHEMICAL STRUCTURE *) wherein R1 and R2 are each long chain hydrocarbons containing 12-24 carbons.
Abstract:
Alliage binaire de bore utilisé comme source émettrice dans les dispositifs générateurs de rayons ioniques du type à émission de champ, dans lequel le bore est le constituant prédominant de l'alliage, de préférence à raison de 60 atomes pour cent. L'autre constituant de l'alliage est choisi dans le groupe des éléments qui constituent le nickel, le palladium et le platine. La prédominance du bore dans ces alliages favorise, pendant le fonctionnement, la combinaison du bore avec des impuretés à l'état de traces de carbone pour former B4C et ainsi favoriser le mouillage d'un substrat de carbone associé.
Abstract:
Improved system and method for speaker-independent speech token recognition are described. The system is neural network-based and involves processing a sequence of spoken utterance, e.g. separately articulated letters of a name, to identify the same based upon a highest probability match of each utterance with learned speech tokens, e.g. the letters of the English language alphabet, and based upon a highest probability match of the uttered sequence with a defined utterance library, e.g. a list of names. First, the spoken utterance is digitized or captured and processed into a spectral representation. Second, discrete time frames of the spectral representation are classified phonetically using the spectral coefficients. Third, the time-frame outputs are used by a modified Viterbi search to locate segment boundaries, near which such segment boundaries lies the information that is needed to discriminate letters. Fourth, the segmented or bounded representation is reclassified using such information into individual hypothesized letters. Fifth, successive, hypothesized letter scores are analyzed to obtain a high probability match with a spelled word within the utterance library. The system and method comprehend finer distinctions near points of interest used to discriminate difficult-to-recognize letter pair differences such as M/N, B/D, etc.. The system is described in the context of phone line reception of names spelled by remote users.
Abstract:
A liquid metal ion source and alloy, wherein the species to be emitted from the ion source is contained in a congruently vaporizing alloy. In one embodiment, the liquid metal ion source acts as a source of arsenic, and in a source alloy the arsenic is combined with palladium, preferably in a liquid alloy having a range of compositions from about 24 to about 33 atomic percent arsenic. Such an alloy may be readily prepared by a combustion synthesis technique. Liquid metal ion sources thus prepared produce arsenic ions for implantation, have long lifetimes, and are highly stable in operation.
Abstract:
A liquid metal ion source (10) and alloy for the simultaneous ion evaporation of arsenic and boron, arsenic and phosphorus, or arsenic, boron and phosphorus. The ionic species to be evaporated are contained in palladium-arsenic-boron and palladium-arsenic-boron-phosphorus alloys. The ion source (10), including an emitter means such as a needle emitter (12) and a source means such as U-shaped heater element (14), is preferably constructed of rhemium and tungsten, both of which are readily fabricated. The ion sources (10) emit continuous beams of ions having sufficiently high currents of the desired species to be useful in ion implantation of semiconductor wafers for preparing integrated circuit devices. The sources are stable in operation, experience little corrosion during operation, and have long operating lifetimes.
Abstract:
A substrate for the growth of monocrystalline beta -SiC is formed by providing a body of monocrystalline hexagonal material having a planar surface with a lattice parameter that is within +/-5% of the lattice parameter of 6H alpha -SiC in the basal plane and growing a body of monocrystalline cubic material on the surface to provide a planar cubic material surface that is without grain boundaries, subgrain boundaries, double positioning boundaries, and pits. The cubic material, for example TiC, ZrC, HfC, or TiN, has a rock salt structure and a lattice parameter within +/-5% of the lattice parameter of beta -SiC. Monocrystalline beta -SiC can be nucleated and grown on the surface of the cubic material.
Abstract:
Improved system and method for speaker-independent speech token recognition are described. The system is neural network-based and involves processing a sequence of spoken utterance, e.g. separately articulated letters of a name, to identify the same based upon a highest probability match of each utterance with learned speech tokens, e.g. the letters of the English language alphabet, and based upon a highest probability match of the uttered sequence with a defined utterance library, e.g. a list of names. First, the spoken utterance is digitized or captured and processed into a spectral representation. Second, discrete time frames of the spectral representation are classified phonetically using the spectral coefficients. Third, the time-frame outputs are used by a modified Viterbi search to locate segment boundaries, near which such segment boundaries lies the information that is needed to discriminate letters. Fourth, the segmented or bounded representation is reclassified using such information into individual hypothesized letters. Fifth, successive, hypothesized letter scores are analyzed to obtain a high probability match with a spelled word within the utterance library. The system and method comprehend finer distinctions near points of interest used to discriminate difficult-to-recognize letter pair differences such as M/N, B/D, etc.. The system is described in the context of phone line reception of names spelled by remote users.