公开(公告)号：DE69806378D1

公开(公告)日：2002-08-08

申请号：DE69806378

申请日：1998-05-11

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： STEEN B

IPC: A61N5/06 ,  H01J20060101 ,  H01J3/10

Abstract: A device for irradiating a limited, defined area where uniform and intense irradiation is obtained of a sharply defined light field (7) of variable size, the light from a halogen lamp (1) or similar incoherent light source being directed by means of an elliptical mirror (2) towards one end surface (3) of a transparent rod (4) whose opposite end surface (6) is thereby uniformly irradiated and is imaged by a lens (7) in the area (9) which has to be irradiated.

公开(公告)号：DE69524238T2

公开(公告)日：2002-07-18

申请号：DE69524238

申请日：1995-09-04

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： BERG KRISTIAN ,  SANDVIK KIRSTEN ,  MOAN JOHAN

IPC: A61K47/00 ,  A61K41/00 ,  A61K47/48

Abstract: The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.

公开(公告)号：DE69524238D1

公开(公告)日：2002-01-10

申请号：DE69524238

申请日：1995-09-04

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： BERG KRISTIAN ,  SANDVIK KIRSTEN ,  MOAN JOHAN

IPC: A61K47/00 ,  A61K41/00 ,  A61K47/48

Abstract: The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.

公开(公告)号：DE60111539T2

公开(公告)日：2006-05-11

申请号：DE60111539

申请日：2001-07-25

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： KLAVENESS JO ,  HANSSON VIDAR ,  GODAL ASLAK

IPC: A61K31/195 ,  A61K47/02 ,  A61K9/00 ,  A61K9/70 ,  A61K31/122 ,  A61K31/197 ,  A61K31/22 ,  A61K31/24 ,  A61K31/37 ,  A61K31/409 ,  A61K45/08 ,  A61K47/20 ,  A61K47/24 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61P1/02 ,  A61P1/04 ,  A61P11/00 ,  A61P11/02 ,  A61P15/00 ,  A61P15/02 ,  A61P17/00 ,  A61P17/06 ,  A61P27/02 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/22 ,  A61P35/00 ,  A61P43/00

Abstract: The present invention relates to a pharmaceutical composition for use as a medicament, preferably for the treatment or diagnosis of disorders or abnormalities of epithelial-lined surfaces, preferably mucosa-lined surfaces, comprising a photochemotherapeutic agent together with a mucoadhesive agent, optionally together with at least one surface penetration assisting agent and optionally with one or more chelating agents, and products and kits for performing the invention.

公开(公告)号：DE69806378T2

公开(公告)日：2003-02-13

申请号：DE69806378

申请日：1998-05-11

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： STEEN B

IPC: A61N5/06 ,  H01J20060101 ,  H01J3/10

Abstract: A device for irradiating a limited, defined area where uniform and intense irradiation is obtained of a sharply defined light field (7) of variable size, the light from a halogen lamp (1) or similar incoherent light source being directed by means of an elliptical mirror (2) towards one end surface (3) of a transparent rod (4) whose opposite end surface (6) is thereby uniformly irradiated and is imaged by a lens (7) in the area (9) which has to be irradiated.

公开(公告)号：DE60111539D1

公开(公告)日：2005-07-21

申请号：DE60111539

申请日：2001-07-25

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： KLAVENESS JO ,  HANSSON VIDAR ,  GODAL ASLAK

IPC: A61K47/02 ,  A61K9/00 ,  A61K9/70 ,  A61K31/122 ,  A61K31/197 ,  A61K31/22 ,  A61K31/24 ,  A61K31/37 ,  A61K31/409 ,  A61K45/08 ,  A61K47/20 ,  A61K47/24 ,  A61K47/30 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61P1/02 ,  A61P1/04 ,  A61P11/00 ,  A61P11/02 ,  A61P15/00 ,  A61P15/02 ,  A61P17/00 ,  A61P17/06 ,  A61P27/02 ,  A61P27/16 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/22 ,  A61P35/00 ,  A61P43/00 ,  A61K31/195

Abstract: The present invention relates to a pharmaceutical composition for use as a medicament, preferably for the treatment or diagnosis of disorders or abnormalities of epithelial-lined surfaces, preferably mucosa-lined surfaces, comprising a photochemotherapeutic agent together with a mucoadhesive agent, optionally together with at least one surface penetration assisting agent and optionally with one or more chelating agents, and products and kits for performing the invention.

公开(公告)号：DE69613365T2

公开(公告)日：2002-05-02

申请号：DE69613365

申请日：1996-03-08

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： GIERSKCKY ERIK ,  MOAN JOHAN ,  PENG QIAN ,  STEEN HARALD ,  WARLOE TROND ,  BJORSETH ALF

IPC: G01N33/50 ,  A61K31/215 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  C07C227/18 ,  C07C229/22 ,  G01N33/15 ,  G01N33/58 ,  A61K31/195

Abstract: PCT No. PCT/GB96/00553 Sec. 371 Date Dec. 5, 1997 Sec. 102(e) Date Dec. 5, 1997 PCT Filed Mar. 8, 1996 PCT Pub. No. WO96/28412 PCT Pub. Date Sep. 19, 1996The invention provides a pharmaceutical compositions comprising a compound of formula I:R22N-CH2COCH2-CH2CO-OR1(I)wherein, R1 and R2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.

公开(公告)号：DE69613365D1

公开(公告)日：2001-07-19

申请号：DE69613365

申请日：1996-03-08

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： GIERSKCKY ERIK ,  MOAN JOHAN ,  PENG QIAN ,  STEEN HARALD ,  WARLOE TROND ,  BJORSETH ALF

IPC: G01N33/50 ,  A61K31/215 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  C07C227/18 ,  C07C229/22 ,  G01N33/15 ,  G01N33/58 ,  A61K31/195

Abstract: PCT No. PCT/GB96/00553 Sec. 371 Date Dec. 5, 1997 Sec. 102(e) Date Dec. 5, 1997 PCT Filed Mar. 8, 1996 PCT Pub. No. WO96/28412 PCT Pub. Date Sep. 19, 1996The invention provides a pharmaceutical compositions comprising a compound of formula I:R22N-CH2COCH2-CH2CO-OR1(I)wherein, R1 and R2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.