公开(公告)号：DE69524238T2

公开(公告)日：2002-07-18

申请号：DE69524238

申请日：1995-09-04

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： BERG KRISTIAN ,  SANDVIK KIRSTEN ,  MOAN JOHAN

IPC: A61K47/00 ,  A61K41/00 ,  A61K47/48

Abstract: The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.

公开(公告)号：DE69524238D1

公开(公告)日：2002-01-10

申请号：DE69524238

申请日：1995-09-04

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： BERG KRISTIAN ,  SANDVIK KIRSTEN ,  MOAN JOHAN

IPC: A61K47/00 ,  A61K41/00 ,  A61K47/48

Abstract: The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells by the photodynamic treatment. More particularly, this invention includes a method for transferring DNA and/or RNA, such as genes, to cells by photochemically inducing the disruption of endosomes and lysosomes.

公开(公告)号：DE69613365T2

公开(公告)日：2002-05-02

申请号：DE69613365

申请日：1996-03-08

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： GIERSKCKY ERIK ,  MOAN JOHAN ,  PENG QIAN ,  STEEN HARALD ,  WARLOE TROND ,  BJORSETH ALF

IPC: G01N33/50 ,  A61K31/215 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  C07C227/18 ,  C07C229/22 ,  G01N33/15 ,  G01N33/58 ,  A61K31/195

Abstract: PCT No. PCT/GB96/00553 Sec. 371 Date Dec. 5, 1997 Sec. 102(e) Date Dec. 5, 1997 PCT Filed Mar. 8, 1996 PCT Pub. No. WO96/28412 PCT Pub. Date Sep. 19, 1996The invention provides a pharmaceutical compositions comprising a compound of formula I:R22N-CH2COCH2-CH2CO-OR1(I)wherein, R1 and R2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.

公开(公告)号：DE69613365D1

公开(公告)日：2001-07-19

申请号：DE69613365

申请日：1996-03-08

Applicant: PHOTOCURE ASA OSLO OSLO

Inventor： GIERSKCKY ERIK ,  MOAN JOHAN ,  PENG QIAN ,  STEEN HARALD ,  WARLOE TROND ,  BJORSETH ALF

IPC: G01N33/50 ,  A61K31/215 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  C07C227/18 ,  C07C229/22 ,  G01N33/15 ,  G01N33/58 ,  A61K31/195

Abstract: PCT No. PCT/GB96/00553 Sec. 371 Date Dec. 5, 1997 Sec. 102(e) Date Dec. 5, 1997 PCT Filed Mar. 8, 1996 PCT Pub. No. WO96/28412 PCT Pub. Date Sep. 19, 1996The invention provides a pharmaceutical compositions comprising a compound of formula I:R22N-CH2COCH2-CH2CO-OR1(I)wherein, R1 and R2 have any of the values defined in the specification; or a salt thereof; and a pharmaceutically acceptable carrier or excipient. The invention also provides a method for the diagnosis or photochemotherapeutic treatment of disorders or abnormalities of external or internal surfaces of the body using such compounds or salts.