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    BIODEGRADABLE COMPOSITIONS SUITABLE FOR CONTROLLED RELEASE
    2.
    发明申请
    BIODEGRADABLE COMPOSITIONS SUITABLE FOR CONTROLLED RELEASE 审中-公开
    适用于控制释放的可生物降解组合物

    公开(公告)号：WO2012131104A3

    公开(公告)日：2013-01-03

    申请号：PCT/EP2012055993

    申请日：2012-04-02

    Applicant: INGELL TECHNOLOGIES HOLDING B V ,  BRUIN PETER ,  PETIT AUDREY ,  LEEUW DE MIKE ,  PIEST MARTIN ,  MEIJBOOM RONALD

    Inventor： BRUIN PETER ,  PETIT AUDREY ,  LEEUW DE MIKE ,  PIEST MARTIN ,  MEIJBOOM RONALD

    IPC: A61K9/06 ,  A61K47/34 ,  A61K49/04 ,  C08G63/08 ,  C08G63/91

    CPC classification number: A61K31/167 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/415 ,  A61K31/573 ,  A61K38/13 ,  A61K38/385 ,  A61K38/47 ,  A61K39/395 ,  A61K47/30 ,  A61K47/34 ,  A61K47/50 ,  A61K49/04 ,  A61K49/0442 ,  A61K49/0457 ,  A61K51/06 ,  A61K51/065 ,  C08G63/664 ,  C08G63/6822

    Abstract: The invention describes a special class of drug-depot forming triblock copolymers which are very suitable for the loading, containment and releasing of sensitive drugs such as proteins from biodegradable, injectable drug depots. Furthermore the invention describes how to visualize these depots for various imaging related purposes. The invention relates to a composition comprising a tri-block copolymer according to formula 1 B-A-B (1), wherein A stands for a linear poly-(ethylene glycol) block and wherein B stands for wherein B stands for a poly(lactide-co-e-caprolactone) block, wherein the hydroxyl end-groups of the tri-block copolymer are at least partially acylated with an optionally substituted acyl having 2 to 12 C-atoms, C-atoms of the substituents included;an active ingredient, preferably a pharmaceutically active ingredient and a solvent, wherein the block ratio of the tri-block copolymer, which ratio is defined as the ratio between the sum of the average molecular weight of the B- blocks and the sum of the average molecular weight of the A-block ranges from 1.4 to 3.5. This composition is suitable for controlled release of a pharmaceutically active ingredient.

    Abstract translation: 本发明描述了一种特殊类型的药物储库形成三嵌段共聚物，其非常适合于由可生物降解的可注射药物库中的敏感药物如蛋白质的加载，容纳和释放。 此外，本发明描述了如何将这些仓库可视化用于各种成像相关目的。 本发明涉及包含根据式1的三嵌段共聚物BAB（1）的组合物，其中A代表线性聚（乙二醇）嵌段，其中B代表其中B代表聚（丙交酯共 - ε-己内酯）嵌段，其中三嵌段共聚物的羟基端基至少部分地用任选取代的具有2至12个C原子的酰基，包括的取代基的C-原子酰化;活性成分，优选为 药物活性成分和溶剂，其中三嵌段共聚物的嵌段比率定义为B嵌段的平均分子量之和与A-嵌段共聚物的平均分子量之和的比率， 阻止范围从1.4到3.5。 该组合物适于控制药物活性成分的释放。

    BIODEGRADABLE COMPOSITIONS SUITABLE FOR CONTROLLED RELEASE
    4.
    发明申请
    BIODEGRADABLE COMPOSITIONS SUITABLE FOR CONTROLLED RELEASE 审中-公开
    适用于控制释放的可生物降解组合物

    公开(公告)号：WO2012131104A2

    公开(公告)日：2012-10-04

    申请号：PCT/EP2012/055993

    申请日：2012-04-02

    Applicant: Ingell Technologies Holding B.V. ,  BRUIN, Peter ,  PETIT, Audrey ,  LEEUW DE, Mike ,  PIEST, Martin ,  MEIJBOOM, Ronald

    Inventor： BRUIN, Peter ,  PETIT, Audrey ,  LEEUW DE, Mike ,  PIEST, Martin ,  MEIJBOOM, Ronald

    IPC: A61K9/06 ,  A61K47/34 ,  A61K49/04 ,  C08G63/08 ,  C08G63/91

    CPC classification number: A61K31/167 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/415 ,  A61K31/573 ,  A61K38/13 ,  A61K38/385 ,  A61K38/47 ,  A61K39/395 ,  A61K47/30 ,  A61K47/34 ,  A61K47/50 ,  A61K49/04 ,  A61K49/0442 ,  A61K49/0457 ,  A61K51/06 ,  A61K51/065 ,  C08G63/664 ,  C08G63/6822

    Abstract: The invention describes a special class of drug-depot forming triblock copolymers which are very suitable for the loading, containment and releasing of sensitive drugs such as proteins from biodegradable, injectable drug depots. Furthermore the invention describes how to visualize these depots for various imaging related purposes. The invention relates to a composition comprising a tri-block copolymer according to formula 1 B-A-B (1), wherein A stands for a linear poly-(ethylene glycol) block and wherein B stands for wherein B stands for a poly(lactide-co-ε-caprolactone) block, wherein the hydroxyl end-groups of the tri-block copolymer are at least partially acylated with an optionally substituted acyl having 2 to 12 C-atoms, C-atoms of the substituents included;an active ingredient, preferably a pharmaceutically active ingredient and a solvent, wherein the block ratio of the tri-block copolymer, which ratio is defined as the ratio between the sum of the average molecular weight of the B- blocks and the sum of the average molecular weight of the A-block ranges from 1.4 to 3.5. This composition is suitable for controlled release of a pharmaceutically active ingredient.

    Abstract translation: 本发明描述了一种特殊类型的药物储库形成三嵌段共聚物，其非常适合于由可生物降解的可注射药物库中的敏感药物如蛋白质的加载，容纳和释放。 此外，本发明描述了如何将这些仓库可视化用于各种成像相关目的。 本发明涉及包含根据式1的三嵌段共聚物BAB（1）的组合物，其中A代表线性聚（乙二醇）嵌段，其中B代表其中B代表聚（丙交酯共 - ε-己内酯）嵌段，其中三嵌段共聚物的羟基端基至少部分地用任选取代的具有2至12个C原子的酰基，包括的取代基的C-原子酰化;活性成分，优选为 药物活性成分和溶剂，其中三嵌段共聚物的嵌段比率定义为B嵌段的平均分子量之和与A-嵌段共聚物的平均分子量之和的比率， 阻止范围从1.4到3.5。 该组合物适于控制药物活性成分的释放。

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