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1.发明专利Integrated microneedle array, composition comprising the microneedle array, and system 有权集成麦克风阵列，包含麦克风阵列的组合和系统
公开(公告)号：JP2014076378A
公开(公告)日：2014-05-01
申请号：JP2013249414
申请日：2013-12-02
Applicant: Stichting Voor De Technische Wetenschappen , スティヒティング フォール デ テヘニッヘ ウェテンスハペンStichting voor de Technische Wetenschappen , Univ Twente , ユニヴァシティート トウェンテ
Inventor： REGINA LUTTGE , SVETLANA NIKOLAJEVNA BYSTROVA , JOOST GERARDUS VAN BENNEKOM , MACIEJ DOMANSKI , PATRICK WILHELMUS HENDRIKUS LOETERS , ROB GERHARDUS HENDRIKUS LAMMERTINK , ALOYSIUS JOHANNES ANTONIUS WINNUBST
CPC classification number: A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , B81B2201/055 , B81B2203/0361 , B81C99/0085 , B81C2201/034
Abstract: PROBLEM TO BE SOLVED: To provide an inexpensive and robust microneedle array having improved properties, and enabling parameters thereof to be easily optimized on demand.SOLUTION: A method of manufacturing a microneedle array includes: a process of selecting a mold capable of generating a microneedle array integrated with a base plate, which is a soft manufacturing mold 46a including a set of incisions of microscopic size defining a shape of a microneedle; and a process of using a filler material 50 to enough fill the incisions of microscopic size to thereby manufacture the microneedle array having a predetermined shape and integrated with the base plate. For the filler material, a water or alcohol based ceramic or polymer-ceramic slurry is selected.
Abstract translation: 要解决的问题：提供一种具有改进性能的廉价且鲁棒的微针阵列，并且使其参数能够根据需要容易地优化。解决方案：制造微针阵列的方法包括：选择能够产生微针的模具的方法 与基板一体化的基板，其是包括限定微针形状的微观尺寸的切口的软制造模具46a; 以及使用填充材料50足以填充微观尺寸的切口的过程，从而制造具有预定形状并与基板一体化的微针阵列。 对于填充材料，选择水或醇基陶瓷或聚合物 - 陶瓷浆料。
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2.发明申请
公开(公告)号：WO2013004644A8
公开(公告)日：2013-08-01
申请号：PCT/EP2012062789
申请日：2012-07-01
Applicant: UNIV TWENTE , LE GAC SEVERINE , BERG VAN DEN ALBERT , ESTEVES TELMA CRISTINA
Inventor： LE GAC SEVERINE , BERG VAN DEN ALBERT , ESTEVES TELMA CRISTINA
CPC classification number: B01L3/502761 , B01L2200/0668 , B01L2300/0663 , B01L2300/0816 , B01L2400/086 , C12M21/06 , C12M23/16 , C12M41/34
Abstract: The invention provides a microfluidic device (10) comprising a chamber (12) for holding at least one embryo (14), said chamber (12) enclosing a volume and comprising an inlet (13) and an outlet (13'), dimensioned for allowing said embryo (14) to enter and leave said chamber (12) and said chamber (12) adapted for holding a culture solution when said microfluidic device (10) is in operation, said chamber (12) further comprising at least one sensor (33, 33') integrated in said chamber (12) for in situ measuring of at least one selected from a chemical, physical and biochemical parameter of said culture solution when said microfluidic device (10) is in operation.
Abstract translation: 本发明提供一种包括用于保持至少一个胚胎（14）的腔室（12）的微流体装置（10），所述腔室（12）封闭一个容积并且包括入口（13）和出口（13'）， 当所述微流体装置（10）运行时，允许所述胚胎（14）进入和离开所述腔室（12）和所述腔室（12），所述腔室（12）还包括至少一个传感器（ 其特征在于，当所述微流体装置（10）处于操作中时，用于原位测量从所述培养溶液的化学，物理和生物化学参数中选择的至少一种参数。
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公开(公告)号：WO2013105859A3
公开(公告)日：2013-11-07
申请号：PCT/NL2013050017
申请日：2013-01-14
Applicant: UNIV TWENTE
CPC classification number: G01L1/148 , G01L1/142 , G01L1/144 , G01L3/02 , G01L5/165 , G01P15/125 , G01R27/2605
Abstract: A sensing device for measuring force and/or torque includes a top part with a top electrode structure, a bottom part with a bottom electrode structure, and a support structure. The support structure (7) includes spring elements for supporting the top part on the bottom part with the top electrode structure (4) parallel to and facing the bottom electrode structure (6). The spring elements provide a gap between the top and bottom electrode structures (6) and allow displacement of the top part relative to the bottom part in three orthogonal directions two parallel and one perpendicular to the bottom plate, and for rotation of the top part relative to the bottom part around three orthogonal axes, corresponding with said two parallel and one perpendicular directions. The displacement and/or rotation induce a change in distance between and/or overlap area of the top and bottom electrodes and a corresponding change of capacitance.
Abstract translation: 用于测量力和/或扭矩的感测装置包括具有顶部电极结构的顶部部分，具有底部电极结构的底部部分和支撑结构。 支撑结构（7）包括用于支撑底部顶部的弹簧元件，顶部电极结构（4）平行于并面向底部电极结构（6）。 弹簧元件在顶部和底部电极结构（6）之间提供间隙，并且允许顶部相对于底部部分在垂直于底板的平行和垂直的三个正交方向上移位，并且允许顶部部分相对于 到三个正交轴的底部，对应于所述两个平行和一个垂直方向。 位移和/或旋转引起顶部和底部电极之间和/或重叠区域之间的距离和相应的电容变化的变化。
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公开(公告)号：WO2011108929A3
公开(公告)日：2011-11-17
申请号：PCT/NL2011050151
申请日：2011-03-04
Applicant: STICHTING TECH WETENSCHAPP , UNIV TWENTE , WESSLING MATTHIAS , STAMATIALIS DIMITRIOS , KOPEC KARINA KATARZYNA , DUTCZAK SZYMON MARIA
CPC classification number: B01D69/125 , B01D69/088 , B01D69/12 , B01D71/60 , D01D5/24
Abstract: The present invention relates to a process for manufacturing a hollow fibre membrane having a supporting layer and a separating layer, said process comprising: (a)extruding a spinning composition comprising a first polymer and a solvent for the first polymer through an inner annular orifice of a hollow-fibre die; (b)co-extruding a composition comprising an organic nucleophilic reagent and a mixtures of a solvent and a non-solvent for the first polymer, wherein the composition is either extruded through a central annular orifice of the hollow-fibre die or through an outer annular orifice of a hollow-fibre die; and (c)passing the hollow-fibre through a coagulation bath. The hollow fibre membrane according to the present invention can be used in gas separation processes, vapour separation processes and liquid filtration processes.
Abstract translation: 本发明涉及一种制造具有支撑层和分离层的中空纤维膜的方法，所述方法包括：（a）通过内部环形孔挤出第一聚合物的第一聚合物和溶剂的纺丝组合物， 中空纤维模; （b）共挤出包含有机亲核试剂的组合物和用于第一聚合物的溶剂和非溶剂的混合物，其中所述组合物通过中空纤维模头的中心环形孔口挤出或通过外部 中空纤维模具的环形孔; 和（c）使中空纤维通过凝固浴。 根据本发明的中空纤维膜可用于气体分离过程，蒸气分离过程和液体过滤过程。
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公开(公告)号：WO2008043509A8
公开(公告)日：2009-12-23
申请号：PCT/EP2007008713
申请日：2007-10-05
Applicant: UNIV TWENTE , HEKMAN EDSKO EVERT GEERT , STIENEN ADRLANUS HUBERTUS ARNO , VAN DER KOOIJ HERMAN
CPC classification number: F16D55/00 , A63B21/015 , A63B24/00 , A63B2220/51 , B60T8/52 , F16D65/18 , F16D2121/02 , F16D2121/14
Abstract: The invention relates to a device for providing a controlled friction on a rotation shaft rotatably arranged on a base, which device comprises: - a friction generating device having a rotatable part connected to the shaft and a stationary part connected to the base; - a pressure sensor arranged between the stationary part and the base in order to measure the counter-force; and - control means for controlling the friction generating device based on the pressure measured by the pressure sensor.
Abstract translation: 本发明涉及一种用于在可旋转地布置在基座上的旋转轴上提供受控摩擦的装置，该装置包括： - 摩擦产生装置，具有连接到轴的可旋转部分和连接到基座的固定部分; - 压力传感器，布置在固定部分和基部之间，以便测量反作用力; 以及 - 控制装置，用于基于由压力传感器测量的压力来控制摩擦产生装置。
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Patent Agency Ranking
公开(公告)号：WO0015326A2
公开(公告)日：2000-03-23
申请号：PCT/NL9900537
申请日：1999-08-30
Applicant: UNIV TWENTE , NIJMEIJER ARIAN , CERES MILIEU HOLDING BV , VERWEIJ HENDRIK
Inventor： NIJMEIJER ARIAN , KRUIDHOF HENDRIK , VERWEIJ HENDRIK
CPC classification number: B01D69/12 , B01D71/025 , B01D71/027
Abstract: A device for separating liquid and/or gas components from each other, which device includes a ceramic membrane comprising a porous layer of gamma -alumina (2) which is present on top of a porous layer of supporting material (1), wherein an alkali-free, phosphorous material (4) is provided between said supporting material (1) and said layer of gamma -alumina (2), and wherein said material preferably consists of monoaluminium phosphate.
Abstract translation: 一种用于将液体和/或气体组分彼此分离的装置，该装置包括陶瓷膜，该陶瓷膜包括存在于支撑材料（1）的多孔层顶部的γ-氧化铝（2）的多孔层，其中碱 在所述支撑材料（1）和所述γ-氧化铝层（2）之间提供了无磷磷材料（4），并且其中所述材料优选由单磷酸铝组成。
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7.发明申请ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF 审中-公开分离的和重组的抗微生物肽血栓素-1（TC-1）和血栓素-2（TC-2）或其变体
公开(公告)号：WO9915548B1
公开(公告)日：1999-09-02
申请号：PCT/EP9806183
申请日：1998-09-25
Applicant: AZ UNIV AMSTERDAM , UNIV TWENTE , NL ORGANISATIE VOOR WETENSCHAP , KRIJGSVELD JEROEN , ZAAT SEBASTIANUS ANTONIUS JOHA , DANKERT JACOB , KUIJPERS ALMA JOHANNA , ENGBERS GERARDUS HENRICUS MARI , FEIJEN JAN
Inventor： KRIJGSVELD JEROEN , ZAAT SEBASTIANUS ANTONIUS JOHA , DANKERT JACOB , KUIJPERS ALMA JOHANNA , ENGBERS GERARDUS HENRICUS MARI , FEIJEN JAN
CPC classification number: C07K14/521 , A61K38/00
Abstract: The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.
Abstract translation: 本发明涉及分离的和重组的抗微生物肽血小板生成素-1（TC-1）和血栓形成素-2（TC-2）或其变体，其至少部分包含如图1所示的由标签TC -1和TC-2，并且对例如大肠杆菌，枯草芽孢杆菌，血链球菌，肺炎链球菌，表皮葡萄球菌和金黄色葡萄球菌，和/或抗真菌的革兰氏阳性菌和革兰氏阴性菌具有抗微生物活性 白色念珠菌，glabarata，新型隐球菌，黄曲霉菌，烟曲霉和假黄曲霉。本发明进一步涉及所述肽或其变体在制备用于治疗细菌或真菌的药物中的用途 人和动物中的感染如心内膜炎以及所述肽或其变体在释放系统中用于预防人和动物中的细菌或真菌感染的用途。
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8.发明申请
公开(公告)号：WO9915548A3
公开(公告)日：1999-06-17
申请号：PCT/EP9806183
申请日：1998-09-25
Applicant: AZ UNIV AMSTERDAM , UNIV TWENTE , NL ORGANISATIE VOOR WETENSCHAP , KRIJGSVELD JEROEN , ZAAT SEBASTIANUS ANTONIUS JOHA , DANKERT JACOB , KUIJPERS ALMA JOHANNA , ENGBERS GERARDUS HENRICUS MARI , FEIJEN JAN
Inventor： KRIJGSVELD JEROEN , ZAAT SEBASTIANUS ANTONIUS JOHA , DANKERT JACOB , KUIJPERS ALMA JOHANNA , ENGBERS GERARDUS HENRICUS MARI , FEIJEN JAN
CPC classification number: C07K14/521 , A61K38/00
Abstract: The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.
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公开(公告)号：WO2011159161A3
公开(公告)日：2012-05-03
申请号：PCT/NL2011050440
申请日：2011-06-20
Applicant: UNIV TWENTE , ENGBERSEN JOHANNES FRANCISCUS JOSEPH , PIEST MARTIN
Inventor： ENGBERSEN JOHANNES FRANCISCUS JOSEPH , PIEST MARTIN
IPC: C08G73/02 , A61K47/48 , C08G65/337
CPC classification number: A61K47/34 , A61K9/06 , A61K9/5146 , C08G65/337 , C08G69/42 , C08G69/48 , C08G73/02 , C08G73/028 , C08G2650/50 , C08L79/02
Abstract: The present invention relates to a boronated polymer according to Formula (1): a process for making the boronated polymer according to Formula (1), drug 10 delivery systems, aggregates, nanoparticles and hydrogels comprising the boronated polymer according to Formula (1).
Abstract translation: 本发明涉及根据式（1）的硼化聚合物：制备根据式（1）的硼化聚合物，包含根据式（1）的硼化聚合物的药物10递送系统，聚集体，纳米颗粒和水凝胶的方法。
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公开(公告)号：WO2013172708A8
公开(公告)日：2014-05-30
申请号：PCT/NL2013050357
申请日：2013-05-14
Applicant: UNIV TWENTE
Inventor： VERSLUIS ANDREAS MICHAEL , SEGERS TIM JOSEPH
CPC classification number: A61K49/223 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2400/0439 , B01L2400/0487 , B01L2400/0496 , G01N15/0255 , G01N2015/0288 , G01N2015/142 , G01N2015/149
Abstract: Disclosed is a continuous method of size-sorting microbubbles, comprising: providing a polydisperse plurality of microbubbles (70); entraining said microbubbles (70) in a fluid flow (46) flowing in a flow direction (x+) towards a collection location (62); at an insonification location (60) upstream of the collection location (62), subjecting the microbubbles (70) in said fluid flow (46) to an acoustic pressure wave (52) propagating in a wave direction with a non-zero directional component in a microbubble segregation dimension (y) that extends perpendicular to the flow direction (x+), thereby segregating microbubbles of different equilibrium radius (ro) in said microbubble segregation dimension (y) as they pass the insonification location; and at said collection location (62), collecting the microbubbles (70) present within at least two spatial ranges (44a-c) of said microbubble segregation dimension (y). Also disclosed is an apparatus (1) implementing the method.
Abstract translation: 公开了一种连续的尺寸分选微泡的方法，包括：提供多分散的多个微泡（70）; 在流向（x +）朝向收集位置（62）流动的流体流（46）中夹带所述微泡（70）; 在收集位置（62）上游的增音位置（60）处，使所述流体流（46）中的微泡（70）经受在波方向上以非零方向分量传播的声压波（52） 所述微气泡分离尺寸（y）垂直于所述流动方向（x +）延伸，从而在所述微泡偏析尺寸（y）中通过所述微泡位置时分离不同平衡半径（ro）的微泡; 并且在所述收集位置（62）处收集存在于所述微泡分离尺寸（y）的至少两个空间范围（44a-c）内的微泡（70）。 还公开了实现该方法的装置（1）。
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