公开(公告)号：WO2006089307A3

公开(公告)日：2006-11-23

申请号：PCT/US2006006550

申请日：2006-02-21

Applicant: IROBOT CORP ,  ZIEGLER ANDREW ,  MORESE CHRISTOPHER JOHN ,  DUSSAULT NANCY ,  JONES ANDREW ,  PRATT SCOTT ,  GILBERT DUANE ,  SANDIN PAUL ,  KONANDREAS STEPHANOS

Inventor： ZIEGLER ANDREW ,  MORESE CHRISTOPHER JOHN ,  DUSSAULT NANCY ,  JONES ANDREW ,  PRATT SCOTT ,  GILBERT DUANE ,  SANDIN PAUL ,  KONANDREAS STEPHANOS

IPC: A47L11/00 ,  A47L11/40

CPC classification number: A47L11/302 ,  A47L5/14 ,  A47L7/0028 ,  A47L7/0038 ,  A47L7/0042 ,  A47L9/009 ,  A47L9/10 ,  A47L9/28 ,  A47L9/2826 ,  A47L9/2852 ,  A47L9/2857 ,  A47L9/2873 ,  A47L9/2884 ,  A47L11/40 ,  A47L11/4005 ,  A47L11/4011 ,  A47L11/4016 ,  A47L11/4027 ,  A47L11/4041 ,  A47L11/4044 ,  A47L11/4061 ,  A47L11/4066 ,  A47L11/4069 ,  A47L11/4083 ,  A47L11/4088 ,  A47L2201/00 ,  A47L2201/022 ,  A47L2201/04 ,  B60B33/001 ,  B60B33/0021 ,  B60B33/0028 ,  B60B33/0039 ,  B60B33/0049 ,  B60B33/0057 ,  B60B33/0068 ,  B60B33/0073 ,  B60B33/028 ,  B60R19/483 ,  C11D1/62 ,  C11D1/75 ,  F04D29/4233 ,  G05D1/0219 ,  G05D1/0225 ,  G05D1/0227 ,  G05D1/0272 ,  G05D2201/0203 ,  Y10S901/01 ,  Y10S901/40

Abstract: An autonomous floor cleaning robot (100) includes a transport drive and control system (300,900) arranged for autonomous movement of the robot over a floor for performing cleaning operations. The robot chassis (102) carries a first cleaning zone (A) comprising cleaning elements arranged to suction loose particulates up from the cleaning surface and a second cleaning zone (B) comprising cleaning elements arranged to apply a cleaning fluid onto the surface and to thereafter collect the cleaning fluid up from the surface after it has been used to clean the surface. The robot chassis carries a supply of cleaning fluid and a waste container (D) for storing waste materials collected up from the cleaning surface .

Abstract translation: 自动地板清洁机器人（100）包括传送驱动和控制系统（300,900），其被布置用于机器人在地板上的自动移动以进行清洁操作。 机器人底盘（102）承载第一清洁区域（A），其包括布置成从清洁表面向上吸入松散颗粒的清洁元件和包括清洁元件（B）的第二清洁区域（B），该清洁区域布置成将清洁流体施加到表面上，此后 在清洁表面后，从表面向上收集清洁液。 机器人底盘运送清洁液供应源和用于储存从清洁表面收集的废物的废物容器（D）。

公开(公告)号：WO2006116412A3

公开(公告)日：2006-11-02

申请号：PCT/US2006/015646

申请日：2006-04-26

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  ASO, Kazuyoshi ,  GYOTEN, Michiyo ,  GYORKOS, Albert Charles ,  CORRETTE, Christopher Peter ,  CHO, Suk Young ,  PRATT, Scott Alan ,  SIEDEM, Christopher Stephen

Inventor： ASO, Kazuyoshi ,  GYOTEN, Michiyo ,  GYORKOS, Albert Charles ,  CORRETTE, Christopher Peter ,  CHO, Suk Young ,  PRATT, Scott Alan ,  SIEDEM, Christopher Stephen

IPC: C07D235/24 ,  C07D235/04 ,  C07D235/12 ,  C07D235/18 ,  C07D403/02

Abstract: There is provided a CRF receptor antagonist comprising a compound of the formula (I) : wherein R1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic group, an optionally substituted N-linked heteroaryl group, a cyano or an acyl; R2 is an optionally substituted cyclic hydrocarbyl or an optionally substituted heterocyclic group; X is oxygen, sulfur or -NR3- (wherein R3 is a hydrogen, an optionally substituted hydrocarbyl or an acyl) ; Y1, Y2 and Y3 are each an optionally substituted carbon or a nitrogen, provided that one or less of Y1, Y2 and Y3 is nitrogen; and Z is a bond, -CO-, oxygen, sulfur, -SO-, -SO2-, -NR4-, -NR4-alk-, -CONR4- or -NR4CO- (wherein alk is an optionally substituted C3.-4 alkylene and R4 is a hydrogen, an optionally substituted hydrocarbyl or an acyl) ; or a salt thereof or a prodrug thereof .

公开(公告)号：WO2006116412A2

公开(公告)日：2006-11-02

申请号：PCT/US2006015646

申请日：2006-04-26

Applicant: TAKEDA PHARMACEUTICAL ,  GYORKOS ALBERT ,  CORRETTE CHRISTOPHER ,  CHO SUK ,  PRATT SCOTT ,  SIEDEM CHRISTOPHER ,  ASO KAZUYOSHI ,  GYOTEN MICHIYO

Inventor： GYORKOS ALBERT ,  CORRETTE CHRISTOPHER ,  CHO SUK ,  PRATT SCOTT ,  SIEDEM CHRISTOPHER ,  ASO KAZUYOSHI ,  GYOTEN MICHIYO

IPC: C07D487/02

CPC classification number: C07D403/04 ,  C07D235/26 ,  C07D235/30 ,  C07D335/02 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D409/04 ,  C07D409/10 ,  C07D409/12 ,  C07D413/04 ,  C07D417/10 ,  C07D471/04 ,  C07D471/06 ,  C07D495/04

Abstract: There is provided a CRF receptor antagonist comprising a compound of the formula (I) : wherein R1 is an optionally substituted hydrocarbyl, an optionally substituted C-linked heterocyclic group, an optionally substituted N-linked heteroaryl group, a cyano or an acyl; R2 is an optionally substituted cyclic hydrocarbyl or an optionally substituted heterocyclic group; X is oxygen, sulfur or -NR3- (wherein R3 is a hydrogen, an optionally substituted hydrocarbyl or an acyl) ; Y1, Y2 and Y3 are each an optionally substituted carbon or a nitrogen, provided that one or less of Y1, Y2 and Y3 is nitrogen; and Z is a bond, -CO-, oxygen, sulfur, -SO-, -SO2-, -NR4-, -NR4-alk-, -CONR4- or -NR4CO- (wherein alk is an optionally substituted C3.-4 alkylene and R4 is a hydrogen, an optionally substituted hydrocarbyl or an acyl) ; or a salt thereof or a prodrug thereof .

Abstract translation: 提供了包含式（I）化合物的CRF受体拮抗剂：其中R1是任选取代的烃基，任选取代的C连接的杂环基，任选取代的N-连接的杂芳基，氰基或酰基; R2是任选取代的环状烃基或任选取代的杂环基; X是氧，硫或-NR 3 - （其中R 3是氢，任选取代的烃基或酰基）; Y1，Y2和Y3各自为任选取代的碳或氮，条件是Y1，Y2和Y3中的一个或多个为氮; 并且Z是键，-CO-，氧，硫，-SO - ， - SO 2 - ， - NR 4 - ， - NR 4 - 烷 - ， - CONR 4 - 或-NR 4 CO-（其中alk是任选取代的C 3 -4 亚烷基和R 4是氢，任选取代的烃基或酰基）; 或其盐或其前药。

公开(公告)号：WO2006089307A2

公开(公告)日：2006-08-24

申请号：PCT/US2006/006550

申请日：2006-02-21

Applicant: IROBOT CORPORATION ,  ZIEGLER, Andrew ,  MORESE, Christopher John ,  DUSSAULT, Nancy ,  JONES, Andrew ,  PRATT, Scott ,  GILBERT, Duane ,  SANDIN, Paul ,  KONANDREAS, Stephanos

Inventor： ZIEGLER, Andrew ,  MORESE, Christopher John ,  DUSSAULT, Nancy ,  JONES, Andrew ,  PRATT, Scott ,  GILBERT, Duane ,  SANDIN, Paul ,  KONANDREAS, Stephanos

IPC: A47L11/00

CPC classification number: A47L11/302 ,  A47L5/14 ,  A47L7/0028 ,  A47L7/0038 ,  A47L7/0042 ,  A47L9/009 ,  A47L9/10 ,  A47L9/28 ,  A47L9/2826 ,  A47L9/2852 ,  A47L9/2857 ,  A47L9/2873 ,  A47L9/2884 ,  A47L11/40 ,  A47L11/4005 ,  A47L11/4011 ,  A47L11/4016 ,  A47L11/4027 ,  A47L11/4041 ,  A47L11/4044 ,  A47L11/4061 ,  A47L11/4066 ,  A47L11/4069 ,  A47L11/4083 ,  A47L11/4088 ,  A47L2201/00 ,  A47L2201/022 ,  A47L2201/04 ,  B60B33/001 ,  B60B33/0021 ,  B60B33/0028 ,  B60B33/0039 ,  B60B33/0049 ,  B60B33/0057 ,  B60B33/0068 ,  B60B33/0073 ,  B60B33/028 ,  B60R19/483 ,  C11D1/62 ,  C11D1/75 ,  F04D29/4233 ,  G05D1/0219 ,  G05D1/0225 ,  G05D1/0227 ,  G05D1/0272 ,  G05D2201/0203 ,  Y10S901/01 ,  Y10S901/40

Abstract: An autonomous floor cleaning robot includes a transport drive and control system arranged for autonomous movement of the robot over a floor for performing cleaning operations. The robot chassis carries a first cleaning zone comprising cleaning elements arranged to suction loose particulates up from the cleaning surface and a second cleaning zone comprising cleaning elements arraigned to apply a cleaning fluid onto the surface and to thereafter collect the cleaning fluid up from the surface after it has been used to clean the surface. The robot chassis carries a supply of cleaning fluid and a waste container for storing waste materials collected up from the cleaning surface.

Abstract translation: 自主地板清洁机器人包括传送驱动和控制系统，其被布置成用于机器人在地板上的自动运动以执行清洁操作。 所述机器人机架包括第一清洁区域，所述第一清洁区域包括布置成从所述清洁表面向上抽吸松散颗粒的清洁元件，以及第二清洁区域，所述第二清洁区域包括被清理的清洁元件，以将清洁流体施加到所述表面上， 它已被用来清洁表面。 机器人底盘运送清洁液供应源和用于储存从清洁表面收集的废物的废物容器。

公开(公告)号：WO2004017908A3

公开(公告)日：2004-03-04

申请号：PCT/US2003/026317

申请日：2003-08-21

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  YASUMA, Tsuneo ,  MORI, Akira ,  KAWASE, Masahiro ,  KIMURA, Hiroyuki ,  YOSHIDA, Masato ,  GYORKOS, Albert, Charles ,  PRATT, Scott, Alan ,  CORRETTE, Christopher, Peter

Inventor： YASUMA, Tsuneo ,  MORI, Akira ,  KAWASE, Masahiro ,  KIMURA, Hiroyuki ,  YOSHIDA, Masato ,  GYORKOS, Albert, Charles ,  PRATT, Scott, Alan ,  CORRETTE, Christopher, Peter

IPC: C07D221/04

Abstract: There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X 1 is CR 1 , CR 1 R 2 , N or NR 13 ; X 2 is N or NR 3 ; Y is C, CR 4 or N, Z is CR 5 , CR 5 R 6 , N or NR 7 ; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR 5 or N; R 8 , R 9 ,R 10 , R 11 and R 12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X 1 , R 3 , R 1 , Y and X 3 in formula (II) and (III) as before.

公开(公告)号：WO2013066869A1

公开(公告)日：2013-05-10

申请号：PCT/US2012/062576

申请日：2012-10-30

Applicant: ARRAY BIOPHARMA INC. ,  AICHER, Thomas Daniel ,  BENSCIK, Josef Roland ,  BOYD, Steven Armen ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John Peter ,  HINKLIN, Ronald Jay ,  PRATT, Scott ,  SINGH, Ajay ,  TURNER, Timothy M.

Inventor： AICHER, Thomas Daniel ,  BENSCIK, Josef Roland ,  BOYD, Steven Armen ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John Peter ,  HINKLIN, Ronald Jay ,  PRATT, Scott ,  SINGH, Ajay ,  TURNER, Timothy M.

IPC: C07D413/14 ,  C07D417/14 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/433 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/12 ,  A61P9/00 ,  A61P25/28 ,  A61P25/18

CPC classification number: C07D417/14 ,  C07D413/14

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X 1 , X 2 , X 3 , L, R 3 , R 4 , R 5 , R 7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，X3，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防 的疾病，例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。

公开(公告)号：WO2012037393A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/051821

申请日：2011-09-15

Applicant: ARRAY BIOPHARMA INC. ,  AICHER, Thomas Daniel ,  BENCSIK, Josef R. ,  BOYD, Steven Armen ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John P. ,  HINKLIN, Ronald Jay ,  PRATT, Scott Alan ,  SINGH, Ajay ,  TURNER, Timothy M.

Inventor： AICHER, Thomas Daniel ,  BENCSIK, Josef R. ,  BOYD, Steven Armen ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John P. ,  HINKLIN, Ronald Jay ,  PRATT, Scott Alan ,  SINGH, Ajay ,  TURNER, Timothy M.

IPC: A61K31/4468 ,  A61K31/454 ,  A61P3/04 ,  C07D413/14

CPC classification number: C07D413/14 ,  A61K31/4468 ,  A61K31/454 ,  C07D211/76 ,  C07D401/04 ,  C07D401/14

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X 1 , X 2 , L, R 3 , R 4 , R 5 , R 7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防疾病 例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。

公开(公告)号：WO2011146335A1

公开(公告)日：2011-11-24

申请号：PCT/US2011/036443

申请日：2011-05-13

Applicant: ARRAY BIOPHARMA INC. ,  AICHER, Thomas Daniel ,  BENCSIK, Josef Roland ,  BOYD, Steven Armen ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John P. ,  HINKLIN, Ronald Jay ,  PRATT, Scott Alan ,  SINGH, Ajay ,  TURNER, Timothy M.

Inventor： AICHER, Thomas Daniel ,  BENCSIK, Josef Roland ,  CONDROSKI, Kevin Ronald ,  FELL, Jay Bradford ,  FISCHER, John P. ,  HINKLIN, Ronald Jay ,  PRATT, Scott Alan ,  SINGH, Ajay ,  TURNER, Timothy M.

IPC: C07D401/14 ,  A61K31/4545 ,  A61P3/10

CPC classification number: C07D413/14 ,  C07D401/14 ,  C07D405/14

Abstract: Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which X 1 , X 2 , L, R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 9 , R 9a , and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，L，R3，R4，R5，R6，R6a，R7，R9，R9a和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂 并且可用于治疗或预防诸如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症等疾病。

公开(公告)号：WO2008011130A3

公开(公告)日：2008-10-30

申请号：PCT/US2007016424

申请日：2007-07-20

Applicant: TAKEDA PHARMACEUTICAL ,  KITAMURA SHUJI ,  AICHER THOMAS DANIEL ,  GONZALES STEVE ,  LE HUEROU YVAN ,  PRATT SCOTT ALAN ,  NAKADA YOSHIHISA

Inventor： KITAMURA SHUJI ,  AICHER THOMAS DANIEL ,  GONZALES STEVE ,  LE HUEROU YVAN ,  PRATT SCOTT ALAN ,  NAKADA YOSHIHISA

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D231/14 ,  C07D231/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08

Abstract: The present invention provides compounds represented by the formula (Ie) and the formula (If) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibitory activity and are useful for the prophylaxis, treatment or improvement of diseases or pathologies caused by high expression or high activation of DGAT.

Abstract translation: 本发明提供由式（Ie）和式（If）表示的化合物，其中每个符号如说明书中所定义。 根据本发明，这些化合物具有DGAT抑制活性，并且可用于预防，治疗或改善由DGAT的高表达或高活性引起的疾病或病状。

公开(公告)号：WO2008011130A2

公开(公告)日：2008-01-24

申请号：PCT/US2007/016424

申请日：2007-07-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  KITAMURA, Shuji ,  AICHER, Thomas, Daniel ,  GONZALES, Steve ,  LE HUEROU, Yvan ,  PRATT, Scott, Alan ,  NAKADA, Yoshihisa

Inventor： KITAMURA, Shuji ,  AICHER, Thomas, Daniel ,  GONZALES, Steve ,  LE HUEROU, Yvan ,  PRATT, Scott, Alan ,  NAKADA, Yoshihisa

IPC: A61K31/4178

CPC classification number: C07D401/12 ,  C07D231/14 ,  C07D231/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08

Abstract: The present invention provides compounds represented by the formula (Ie) and the formula (If) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibitory activity and are useful for the prophylaxis, treatment or improvement of diseases or pathologies caused by high expression or high activation of DGAT.

Abstract translation: 本发明提供由式（Ie）和式（If）表示的化合物，其中每个符号如说明书中所定义。 根据本发明，这些化合物具有DGAT抑制活性，可用于预防，治疗或改善由高表达或高活化DGAT引起的疾病或病理。