PROCESS FOR THE FORMATION OF PARTICULATE MATERIAL
    2.
    发明申请
    PROCESS FOR THE FORMATION OF PARTICULATE MATERIAL 审中-公开
    形成颗粒物的方法

    公开(公告)号:WO2006041521A1

    公开(公告)日:2006-04-20

    申请号:PCT/US2005/010635

    申请日:2005-03-31

    Abstract: A process for the formation of particulate material of a desired substance including: (i) charging a vessel with a supercritical fluid ; (ii) agitating the contents of the vessel with a rotary agitator, creating a relatively highly agitated zone and a bulk mixing zone ; (iii) introducing into the agitated vessel a first feed stream comprising a solvent and the desired substance and a second feed stream comprising the supercritical fluid, wherein the desired substance is less soluble in the supercritical fluid relative to tis solubility in the solvent, the first and second feed streams are introduced into the highly agitated zone of the vessel and the first feed stream is dispersed in the supercritical fluid by action of the rotary agitator, allowing extraction of the solvent into the supercritical fluid, and (iv) precipitating particles of the desired substance in the vessel with a volume-weighted average diameter of less than 100 nanometers.

    Abstract translation: 用于形成所需物质的颗粒材料的方法,包括:(i)用超临界流体填充容器; (ii)用旋转搅拌器搅拌容器的内容物,产生相对高度搅拌的区域和本体混合区域; (iii)向搅拌的容器中引入包含溶剂和所需物质的第一进料流和包含超临界流体的第二进料流,其中所需物质相对于溶剂在溶剂中的溶解度较不溶于超临界流体,第一 并且将第二进料流引入容器的高度搅拌的区域中,并且通过旋转搅拌器的作用将第一进料流分散在超临界流体中,从而将溶剂萃取到超临界流体中,和(iv)沉淀出 容器中所需物质的体积加权平均直径小于100纳米。

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