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    METHOD AND DEVICE FOR PREPARING DIALYSING FLUID
    4.
    发明专利
    METHOD AND DEVICE FOR PREPARING DIALYSING FLUID 失效

    公开(公告)号：JP2001286552A

    公开(公告)日：2001-10-16

    申请号：JP2000105226

    申请日：2000-04-06

    Applicant: TOMITA PHARMA

    Inventor： KIKUISHI JUNYA ,  TAMAGAWA KAZUHIKO ,  AOYAMA HIDEYUKI

    IPC: A61M1/14

    Abstract: PROBLEM TO BE SOLVED: To provide a method for preparing a dialysing fluid to be dissolved sanitarily without contact between the preparation and outside air and to be fed at a constant speed and constant concentration, and a device for the dissolution. SOLUTION: The method for preparing a dialysing fluid to be fed with a constant electrolytic concentration using a dialysing agent for the artificial kidney comprised of an agent A containing sodium chloride, an agent B containing sodium bicarbonate, and an agent C containing calcium salt and magnesium salt as electrolytic components is provided. The method comprises: (1) a step of dissolving the agent A in the aqueous solution of the agent C, and (2) a step of mixing the mixed liquid obtained in the process (1) with the aqueous solution of the agent B. In addition, the device for implementing the method is provided.

    PRODUCTION OF UDP-GALNAC
    5.
    发明专利
    PRODUCTION OF UDP-GALNAC 失效

    公开(公告)号：JPH1146789A

    公开(公告)日：1999-02-23

    申请号：JP21490197

    申请日：1997-08-08

    Applicant: TOMITA PHARMA

    Inventor： KABAYAMA MINEAKI ,  SAKIYAMA TORU

    IPC: C12P19/30 ,  C07H1/06 ,  C07H19/10

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful for the development of medicines, etc. at a low cost on a large seale by allowing an epimerase to act on VDP-GlcNac and subsequently applying a column to the product to separate the compound from the raw material, wherein a lectin capable of selectively binding to the compound is immobilized on the column. SOLUTION: This method for producing VDP-GalNAc comprises allowing an epimerase to act on VDP-GlcNAc to convert into the VDP-GalNAc, subjecting the reaction mixture to a column to separate the VDP-GalNAc from the VDP-GlcNAc. A lectin capable of selectively binding to the VDP-GalNAc is immobilized on the column. Thus, the objective VDP-GalNAc can be obtained at a low cost on a large scale. Dolichosbiflorus agglutinin(DBA), Griffonia simplicifolia agglutinin(GSA), Helix pomatia agglutinin(HPA), etc., are desirably used as the lectin capable of selectively binding to the VDP-GalNAc.

    HYDROXYAPATITE TO BE FORMULATED TO TOOTH PASTE AND ITS PRODUCTION
    6.
    发明专利
    HYDROXYAPATITE TO BE FORMULATED TO TOOTH PASTE AND ITS PRODUCTION 失效

    公开(公告)号：JPH0920508A

    公开(公告)日：1997-01-21

    申请号：JP17082595

    申请日：1995-07-06

    Applicant: TOMITA PHARMA

    Inventor： KIWA TOSHIHIRO ,  HIRONO MOTOKO

    IPC: A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  C01B25/32 ,  A61K7/16

    Abstract: PROBLEM TO BE SOLVED: To inhibit the solidification of hydroxyapatite in tubes of tooth pastes or in pumps by allowing an aqueous suspension or solution containing calcium to react with a phosphorus-containing aqueous solution under special conditions. SOLUTION: An aqueous suspension or solution containing 1-70wt.% of calcium hydroxide or a calcium salt and an aqueous solution containing 5-90wt.% of phosphoric acid or a phosphate salt are mixed so that the Ca/P molar ratio may meet 1.60-1.70, to effect their reaction at a pH of 6-8 and a temperature of 90-100 deg.C for 30 minutes to 8 hours to give hydroxyapatite having a half width of /g.

    SURFACE-COATED FIBROUS SUBSTANCE
    7.
    发明专利
    SURFACE-COATED FIBROUS SUBSTANCE 失效

    公开(公告)号：JPH0782096A

    公开(公告)日：1995-03-28

    申请号：JP18059393

    申请日：1993-06-14

    Applicant: TOMITA PHARMA ,  OTSUKA CHEMICAL CO LTD

    Inventor： SUZUE MASAYOSHI ,  MURATA HIROKI ,  MIZOBUCHI HARUE ,  KIWA TOSHIHIRO

    IPC: B01J20/28 ,  B01J35/06 ,  C01B35/14 ,  C04B35/80 ,  C30B29/62

    Abstract: PURPOSE:To improve heat resistance, chemical resistance, ion exchange ability, antimicrobial property, electrically insulating properties and neutron absorbing ability of a fibrous substance by coating the surface of a fibrous substance with aluminum borosulfate or aluminum borate. CONSTITUTION:One or more compounds selected from sulfuric acid salts of Al, hydroxides of Al, hydroxides of alkali metals, carbonic acid salts of alkali metals, aluminic acid salts of alkali metals, carbonic acid salts of ammonium and ammonium hydroxide are made to react in the presence of a fibrous substance such as fibrous alkali metal salt of titanic acid, a fibrous boric acid transition metal salt, a fibrous alkaline earth metal salt of boric acid or ZnO whisker in an equivalent ratio of 1:(4.5-6.0) at 5-80 deg.C for 1-5hr. Then, a boron compound is added thereto and the fibrous substance is made to react with the boron compound at 10-200 deg.C for 1-8hr and the reactional product is washed with water and dried to coat the surface of the fibrous substance with aluminum borosulfate or aluminum borate.

    PRODUCTION OF MAGNESIUM HYDROGEN CITRATE PENTAHYDRATE
    8.
    发明专利
    PRODUCTION OF MAGNESIUM HYDROGEN CITRATE PENTAHYDRATE 失效

    公开(公告)号：JPH06228046A

    公开(公告)日：1994-08-16

    申请号：JP1855393

    申请日：1993-02-05

    Applicant: TOMITA PHARMA

    Inventor： SAKIYAMA TORU ,  KABAYAMA MINEAKI

    IPC: C07C51/41 ,  C07C51/43 ,  C07C59/265

    Abstract: PURPOSE:To provide a production process for magnesium citrate pentahydrate which is excellent in solubilization and storability. CONSTITUTION:Magnesium metal or its salt is allowed to react with citric acid and the reaction product is precipitated to give magnesium hydrogen citrate pentahydrate wherein the citric acid is used in 1.1 to 1.8 mole per mole of magnesium metal or its salt.

    ANTIBACTERIAL TITANIUM OXIDE AND PREPARATION THEREOF
    10.
    发明专利
    ANTIBACTERIAL TITANIUM OXIDE AND PREPARATION THEREOF 失效

    公开(公告)号：JPH0352804A

    公开(公告)日：1991-03-07

    申请号：JP18693089

    申请日：1989-07-19

    Applicant: TOMITA PHARMA ,  SHINANEN NEW CERAMIC KK

    Inventor： OKUBO AKIRA ,  SAIDA YOSHIO ,  UCHIDA SHINJI ,  KURIHARA YASUO

    IPC: A01N59/16 ,  C01G23/053

    Abstract: PURPOSE:To prepare an antibacterial titanium oxide having excellent antibacterial activity persistence, high hydrophilicity and masking power, no skin irritation property and excellent UV light absorbability by substituting one part or all of ion-exchangeable ions contained in the titanium oxide with antibacterial metal ions. CONSTITUTION:A mixture solution containing four valent titanium and three valent titanium in a molar ratio of 6-720:1 is preferably hydrolyzed and subsequently mixed with an antibacterial metal solution adjusted to a pH of 5-10 to substitute one part or all of ion-exchangeable ions contained in the titanium oxide with antibacterial metal ions, preferably the ions of silver, copper, zinc, mercury, lead, cadmium, chromium and/or thallium to provide an antibacterial titanium oxide which has high ion exchange stability without damaging the fundamental physical properties (hydrophilicity, masking power, stability and UV light absorbability) of the titanium and which has the above-mentioned properties and the antibacterial property imparted by the introduction of the above-mentioned ions.

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