公开(公告)号：KR101207553B1

公开(公告)日：2012-12-03

申请号：KR1020050047235

申请日：2005-06-02

Applicant: (주)씨앤팜

Inventor： 박태운 ,  최진호 ,  오제민 ,  정지선

IPC: A61K47/02 ,  A61K9/08

CPC classification number: A61K9/0019 ,  A61K9/143 ,  A61K47/02

Abstract: 본발명은무독성금속이중층수산화물및 약제학적으로허용가능한첨가제를포함하는주사제용약물담체에관한것이다. 보다구체적으로, 본발명은다양한조성을갖는금속이중층수산화물을합성하는단계, 생체파괴를일으키지않는수준으로금속이중층수산화물의크기와입형을조절하는단계, 금속이중층수산화물을용매에분산시켜생체에주입하는단계를포함한다. 본발명에따르면, 생물체의혈관에영향을주지않는나노크기의금속이중층수산화물을합성할수 있으며, 이렇게합성된금속이중층수산화물은 400mg/kg 까지의투여량에도생체에악영향을끼치지않으면서, 특정약물의전달효율을높일수 있는약물전달체시스템을확립할수 있다.

公开(公告)号：KR1020060125280A

公开(公告)日：2006-12-06

申请号：KR1020050047235

申请日：2005-06-02

Applicant: (주)씨앤팜

Inventor： 박태운 ,  최진호 ,  오제민 ,  정지선

IPC: A61K47/02 ,  A61K9/08

CPC classification number: A61K9/0019 ,  A61K9/143 ,  A61K47/02

Abstract: An injectable drug carrier comprising double-layered hydroxide is provided to remove a destruction risk of blood vessel by the double-layered hydroxide, and deliver an effective drug into the human body without toxicity and side effects. The injectable drug carrier comprises the nontoxic double-layered hydroxide and a pharmaceutically acceptable additive, wherein the particle size of the double layered hydroxide is 100-300 nm; and drug is MTX(methotrexate). The method for preparing the injectable drug carrier comprises the steps of: titrating divalent or trivalent metal salt solution with base solution to synthesize the double-layered hydroxide by hydro thermal method or at room temperature; and regulating the particle size of the synthesized double-layered hydroxide, wherein the divalent metal is magnesium, calcium or zinc, and the trivalent metal is aluminum or iron; and the base solution is sodium hydroxide or ammonia.

Abstract translation: 提供包含双层氢氧化物的可注射药物载体以通过双层氢氧化物去除血管的破坏风险，并将有效药物输送到人体内而没有毒副作用。 可注射药物载体包含无毒双层氢氧化物和药学上可接受的添加剂，其中双层氢氧化物的粒径为100-300nm; 药物是MTX（甲氨蝶呤）。 制备可注射药物载体的方法包括以下步骤：用碱溶液滴定二价或三价金属盐溶液，通过水热法或室温合成双层氢氧化物; 并调节合成的双层氢氧化物的粒度，其中二价金属是镁，钙或锌，三价金属是铝或铁; 碱溶液为氢氧化钠或氨。