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1.发明公开
公开(公告)号：KR1020060132409A
公开(公告)日：2006-12-21
申请号：KR1020050052743
申请日：2005-06-18
Applicant: (주)씨앤팜
CPC classification number: A21D2/22 , A21D2/02 , A21D2/16 , A21D2/165 , A21D2/183 , A21D2/188 , A21D2/34
Abstract: Provided are a bread improver, which substitutes noxious bread improvers, improves dough to reduce the time involved in making bread, and provides bread having dense textures, and a preparation thereof. The bread improver comprises: a hybrid of vitamin C and layered metal hydroxides or metal oxides; and a vitamin C-releasing retarder selected from the group consisting of lecithin, cellulose, xanthan gum, guar gum, methylcellulose, hydroxypropylmethylcellulose, ethylcellulose, monoglyceride, diglyceride, polyglycerolester, beeswax, and a mixture thereof. The vitamin C is contained in an amount of 0.1-55wt% based on the total weight of the bread improver.
Abstract translation: 提供了一种面包改良剂，其代替有害的面包改良剂，改善面团以减少制作面包的时间，并提供具有致密纹理的面包及其制备。 面包改良剂包括：维生素C和层状金属氢氧化物或金属氧化物的杂化物; 和选自卵磷脂，纤维素，黄原胶，瓜尔胶，甲基纤维素，羟丙基甲基纤维素，乙基纤维素，甘油单酯，甘油二酯，聚甘油酯，蜂蜡及其混合物的维生素C释放缓释剂。 基于面包改良剂的总重量，维生素C的含量为0.1-55重量％。
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公开(公告)号：KR100937205B1
公开(公告)日：2010-01-19
申请号：KR1020070073442
申请日：2007-07-23
Applicant: (주)씨앤팜
IPC: A61K9/18 , A61K9/14 , A61K31/164
Abstract: 본 발명은 활성성분이 생체 친화성 공중합 고분자 계면활성제의 미셀 중에 담지된 활성성분-미셀의 복합체가 메조 다공성 무기 구조체의 동공 중에 혼성화된 혼성물질, 그 제조방법, 및 그 혼성물질을 포함하는 완제품을 제공한다.
메조 다공성 무기 구조체, 혼성 물질, 약물 전달체-
公开(公告)号：KR1020060093240A
公开(公告)日：2006-08-24
申请号：KR1020050014273
申请日：2005-02-21
Applicant: (주)씨앤팜
IPC: A61K47/48
CPC classification number: A61K31/4525 , A61K9/1611 , A61K9/1635 , A61K31/137 , A61K31/445 , A61K47/50
Abstract: 본 발명은 난용성 염기형 약물과 층상형 규산염간의 하이브리드 물질에 수용성 염기 폴리머가 첨가된 혼성체의 약학적 조성 및 그 제조방법에 관한 것이다. 상기 수용성 고분자로는 아미노알킬메타크릴레이트 공중합체(예를들어, 데구사(Degussa)의 유드라지트 E 100(Eudragit E 100: poly(butyl methacrylate, (2-dimethyl aminoethyl)methacrylate, methyl methacrylate) 1:2:1) 또는 폴리비닐아세탈 디에틸아미노아세테이트(AEA)등을 사용할 수 있다.
본 발명에 따르면 경구용 제제의 원료로 사용되는 유-무기 하이브리드 물질에서의 난용성 약물의 용출률을 단시간 내에 90% 가까이 높여 체내 흡수율에 대한 효율성을 높이는데 유용하다.-
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公开(公告)号：KR1020040010306A
公开(公告)日：2004-01-31
申请号：KR1020030050119
申请日：2003-07-22
Applicant: (주)씨앤팜
IPC: A61K47/02
CPC classification number: A61K31/403 , A61K9/143 , A61K31/496 , A61K38/13
Abstract: PURPOSE: Provided are a hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same, thereby releasing drugs from the layered silicate and maximizing their bioavailability in the living body. CONSTITUTION: A hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate is characterized in that itraconazole, cyclosporine or carvedilol is inserted between silicate layers or absorbed to the surface of the layered silicate. It is manufactured by the steps of: preparing a solution containing layered silicate by dispersing the layered silicate in a water soluble solvent; preparing a drugs-containing solution by dissolving drugs in an organic solvent; and mixing the above solutions together to insert drugs between silicate layers or absorb them to the surface to the surface of the layered silicate.
Abstract translation: 目的：提供伊曲康唑，环孢菌素或卡维地洛与层状硅酸盐的混合物及其制备方法，从而从层状硅酸盐释放药物并使其在生物体中的生物利用度最大化。 构成：伊曲康唑，环孢菌素或卡维地洛与层状硅酸盐的混合物的特征在于，伊曲康唑，环孢菌素或卡维地洛插入硅酸盐层之间或吸收到层状硅酸盐的表面。 通过以下步骤制造：通过将层状硅酸盐分散在水溶性溶剂中来制备含有层状硅酸盐的溶液; 通过将药物溶解在有机溶剂中制备药物溶液; 并将上述溶液混合在一起，将药物插入硅酸盐层之间或将其吸收到层状硅酸盐表面。
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Patent Agency Ranking
公开(公告)号：KR1020080031763A
公开(公告)日：2008-04-11
申请号：KR1020060097719
申请日：2006-10-05
Applicant: (주)씨앤팜
Inventor： 박태운
Abstract: A target delivery method of an anti-cancer drug is provided to increase in vivo retention time and selectivity to cancer cells by increasing molecular weight with LDH(layered double hydroxide), minimize side effects and maximize drug effects by controlling the size of LDH nanoparticles, selectively delivering the drug to cancer cells, and promoting cell entrance and delivery by endocytosis. A method for inhibiting growth of cancer cells selectively comprises the steps of: regulating the size of metal layered double hydroxide(LDH) to 50-450 nm and inserting an anti-cancer drug MTX(methotrexate) between layers of the LDH through ion exchange to prepare a MTX/LDH hybrid; and administering the MTX/LDH hybrid to a cancer patient through injection, wherein the cancer cell is MNNG/HOS(N-methyl-N'-nitro-N-nitroso-guanidine/human osteosarcoma).
Abstract translation: 提供抗癌药物的靶递送方法，以通过用LDH（层状双氢氧化物）增加分子量来增加体内保留时间和对癌细胞的选择性，通过控制LDH纳米颗粒的尺寸来最小化副作用并最大化药物作用， 选择性地将药物递送至癌细胞，并通过内吞促进细胞进入和递送。 选择性地抑制癌细胞生长的方法包括以下步骤：将金属层状双氢氧化物（LDH）的尺寸调节至50-450nm，并通过离子交换将LDH的层之间的抗癌药物MTX（甲氨蝶呤）插入到 制备MTX / LDH杂交体; 并通过注射给予癌症患者MTX / LDH杂交体，其中癌细胞是MNNG / HOS（N-甲基-N'-硝基-N-亚硝基胍/人骨肉瘤）。
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公开(公告)号：KR101207553B1
公开(公告)日：2012-12-03
申请号：KR1020050047235
申请日：2005-06-02
Applicant: (주)씨앤팜
CPC classification number: A61K9/0019 , A61K9/143 , A61K47/02
Abstract: 본발명은무독성금속이중층수산화물및 약제학적으로허용가능한첨가제를포함하는주사제용약물담체에관한것이다. 보다구체적으로, 본발명은다양한조성을갖는금속이중층수산화물을합성하는단계, 생체파괴를일으키지않는수준으로금속이중층수산화물의크기와입형을조절하는단계, 금속이중층수산화물을용매에분산시켜생체에주입하는단계를포함한다. 본발명에따르면, 생물체의혈관에영향을주지않는나노크기의금속이중층수산화물을합성할수 있으며, 이렇게합성된금속이중층수산화물은 400mg/kg 까지의투여량에도생체에악영향을끼치지않으면서, 특정약물의전달효율을높일수 있는약물전달체시스템을확립할수 있다.
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公开(公告)号：KR1020080009653A
公开(公告)日：2008-01-29
申请号：KR1020070073442
申请日：2007-07-23
Applicant: (주)씨앤팜
IPC: A61K9/18 , A61K9/14 , A61K31/164
CPC classification number: A61K9/1611 , A61K9/127 , A61K9/1629 , A61K9/1682 , A61K31/164
Abstract: A mixture material in which a complex of an active ingredient-micelle is hybridized into pores of a meso porous inorganic structure is provided to make a drug be stable at light and heat and show the controlled releasing property, thereby lowering the toxicity of the drug itself and also increasing the transmission efficiency of the drug into cells. A method for preparing the same is provided to simply obtain the mixture material with only two steps. A mixture material is characterized in that a complex of an active ingredient-micelle in which the active ingredient is supported on a micelle of a biocompatible copolymeric polymer surfactant is hybridized with pores of a meso porous inorganic structure, wherein the surfactant is a compound of EOnPOmEOn (n is an integer from 20-106 and m is an integer from 40-100), the meso porous inorganic structure is made of SiO2 or TiO2, and the active ingredient is a water-insoluble drug. A method for preparing the mixture material comprises the steps of: (a) reacting an aqueous solution of a mixture consisting of an active ingredient, a biocompatible copolymeric polymer surfactant with the concentration of more than the critical micelle formation, and an inorganic precursor at a temperature of 25-40 deg.C to form a complex of an active ingredient-micelle in which the active ingredient is supported on the micelle of the surfactant; and (b) subjecting the complex formed aqueous solution to hydrothermal reaction at a temperature of 80-130 deg.C to prepare an organic-inorganic complex.
Abstract translation: 提供其中将活性成分胶束的复合物与中孔多孔无机结构的孔杂交的混合材料，以使药物在光和热下稳定并显示出控制释放性质，从而降低药物本身的毒性 并且还将药物的传播效率提高到细胞中。 提供了制备该方法的方法以简单地仅获得两步的混合材料。 混合材料的特征在于将活性成分 - 胶束的复合物与活性成分负载在生物相容性共聚物表面活性剂的胶束上，与内消旋多孔无机结构的孔杂交，其中表面活性剂是EOnPOmOn的化合物 （n为20〜106的整数，m为40〜100的整数），中空多孔无机结构由SiO 2或TiO 2构成，活性成分为水不溶性药物。 一种制备该混合物材料的方法包括以下步骤：（a）使活性成分，生物相容性共聚物表面活性剂的浓度超过临界胶束形成的混合物的水溶液与无机前体反应， 温度为25-40℃，形成活性成分胶束的复合物，其中活性成分负载在表面活性剂的胶束上; 和（b）使复合物形成的水溶液在80-130℃的温度下进行水热反应以制备有机 - 无机络合物。
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公开(公告)号：KR1020060125280A
公开(公告)日：2006-12-06
申请号：KR1020050047235
申请日：2005-06-02
Applicant: (주)씨앤팜
CPC classification number: A61K9/0019 , A61K9/143 , A61K47/02
Abstract: An injectable drug carrier comprising double-layered hydroxide is provided to remove a destruction risk of blood vessel by the double-layered hydroxide, and deliver an effective drug into the human body without toxicity and side effects. The injectable drug carrier comprises the nontoxic double-layered hydroxide and a pharmaceutically acceptable additive, wherein the particle size of the double layered hydroxide is 100-300 nm; and drug is MTX(methotrexate). The method for preparing the injectable drug carrier comprises the steps of: titrating divalent or trivalent metal salt solution with base solution to synthesize the double-layered hydroxide by hydro thermal method or at room temperature; and regulating the particle size of the synthesized double-layered hydroxide, wherein the divalent metal is magnesium, calcium or zinc, and the trivalent metal is aluminum or iron; and the base solution is sodium hydroxide or ammonia.
Abstract translation: 提供包含双层氢氧化物的可注射药物载体以通过双层氢氧化物去除血管的破坏风险，并将有效药物输送到人体内而没有毒副作用。 可注射药物载体包含无毒双层氢氧化物和药学上可接受的添加剂，其中双层氢氧化物的粒径为100-300nm; 药物是MTX（甲氨蝶呤）。 制备可注射药物载体的方法包括以下步骤：用碱溶液滴定二价或三价金属盐溶液，通过水热法或室温合成双层氢氧化物; 并调节合成的双层氢氧化物的粒度，其中二价金属是镁，钙或锌，三价金属是铝或铁; 碱溶液为氢氧化钠或氨。
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10.发明公开
公开(公告)号：KR1020050020157A
公开(公告)日：2005-03-04
申请号：KR1020030057890
申请日：2003-08-21
Applicant: (주)씨앤팜
IPC: A61K47/48
CPC classification number: A61K9/1635 , A61K9/143 , A61K47/50
Abstract: PURPOSE: A hybrid of amlodipine with layered silicate and a preparation process thereof are provided, which hybrid is easily dispersed in aqueous solution to increase bioavailability of amlodipine, and is non-hygroscopic enabling easy manufacturing of formulation. CONSTITUTION: The hybrid of amlodipine with layered silicate is provided, wherein the amlodipine is inserted between layers of silicate; the layered silicate is selected from montmorillonite, beidellite, nontronite, hectorite, saponite, illite, celadonite, gluconite, clay and bentonite; inorganic salt or organic base is added into the hybride in order to regulate release of amlodipine; the organic base is aminoalkyl metacrylate copolymer or polyvinylacetal diethylaminoacetate; and the inorganic salt is selected from calcium salt, sodium salt, potassium salt and ammonium salt. The process for preparing the hybrid of amlodipine with layered silicate comprises the steps of: (1) dispersing the layered silicate in aqueous solution; (2) dissolving amlodipine in ethanol or water; and (3) mixing the layered silicate solution with the amlodipine solution and stirring them.
Abstract translation: 目的：提供氨氯地平与层状硅酸盐的混合物及其制备方法，其混合物容易分散在水溶液中以提高氨氯地平的生物利用度，并且是非吸湿性的，使制剂容易制造。 构成：提供氨氯地平与层状硅酸盐的混合物，其中氨氯地平插入硅酸盐层之间; 层状硅酸盐选自蒙脱石，贝得石，脱镁石，锂蒙脱石，皂石，伊利石，青瓷，葡萄糖甙，粘土和膨润土; 将无机盐或有机碱加入到混合物中以调节氨氯地平的释放; 有机碱是氨基烷基甲基丙烯酸酯共聚物或聚乙烯醇缩二乙基氨基乙酸酯; 无机盐选自钙盐，钠盐，钾盐和铵盐。 制备氨氯地平与层状硅酸盐的混合物的方法包括以下步骤：（1）将层状硅酸盐分散在水溶液中; （2）将氨氯地平溶于乙醇或水中; 和（3）将层状硅酸盐溶液与氨氯地平溶液混合并搅拌。
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