公开(公告)号：KR1020120058995A

公开(公告)日：2012-06-08

申请号：KR1020100120571

申请日：2010-11-30

Applicant: (주)아모레퍼시픽 ,  서울대학교산학협력단

Inventor： 손의동 ,  이진영 ,  나용주 ,  김혜경 ,  김지현 ,  안수미 ,  김한곤 ,  정진호 ,  박치현 ,  서은영 ,  이민정 ,  오인경 ,  윤현선

IPC: C12Q1/68 ,  C12N15/12

CPC classification number: C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5008

Abstract: PURPOSE: A method for screening a gene which characteristically developing aging is provided to control gene expression and to suppress aging on the skin. CONSTITUTION: A method for screening a gene associated with skin aging comprises: a step of extracting total RNA from skin tissue and performing microarray; a step of analyzing genes which are changed by aging using bioinformatics; a step of selecting a candidate gene relating to skin aging; and a step of determining a candidate gene. The skin aging includes intrinsic aging or menopause aging.

Abstract translation: 目的：提供筛选特征性发展老化基因的方法，以控制基因表达并抑制皮肤老化。 构成：筛选与皮肤老化有关的基因的方法包括：从皮肤组织提取总RNA并进行微阵列的步骤; 分析使用生物信息学老化改变的基因的步骤; 选择与皮肤老化有关的候选基因的步骤; 以及确定候选基因的步骤。 皮肤老化包括内在老化或更年期老化。

公开(公告)号：KR1020100106029A

公开(公告)日：2010-10-01

申请号：KR1020090024448

申请日：2009-03-23

Applicant: 서울대학교산학협력단

Inventor： 정진호 ,  강용정 ,  박치현 ,  유현경 ,  서은영 ,  김연경 ,  공경환

IPC: A61K48/00 ,  A61P17/00 ,  A61K8/64 ,  A61Q19/02

CPC classification number: A61K48/0058 ,  A61K8/64 ,  A61Q19/02 ,  Y10S514/847

Abstract: PURPOSE: A composition for skin whitening containing a material which suppresses expression or activation of alpha-synuclein gene is provided to ensure skin whitening activity without citotoxicity. CONSTITUTION: A composition for skin whitening contains a material which suppresses expression or activation of alpha-synuclein gene. A pharmaceutical composition for skin whitening contains the composition. The alpha-synuclein gene encodes alpha-synuclein protein with an amino acid sequence of sequence number 1. The alpha-synuclein gene has a base sequence of sequence number 2. The material is an antibody or antibody fragment which specifically binds to the protein.

Abstract translation: 目的：提供含有抑制α-突触核蛋白基因表达或活化的材料的皮肤美白组合物，以确保皮肤美白活性而不引起宿醉性。 构成：皮肤美白组合物含有抑制α-突触核蛋白基因表达或活化的物质。 用于皮肤美白的药物组合物含有该组合物。 α-突触核蛋白基因编码具有序列号1的氨基酸序列的α-突触核蛋白.α-突触核蛋白基因具有序列号2的碱基序列。该物质是特异性结合蛋白质的抗体或抗体片段。