IL-27을 유효성분으로 포함하는 면역거부질환의 예방 또는 치료용 조성물
    2.
    发明公开
    IL-27을 유효성분으로 포함하는 면역거부질환의 예방 또는 치료용 조성물 有权
    用于预防或治疗包含IL-27作为有效成分的免疫抑制剂的组合物

    公开(公告)号:KR1020120095046A

    公开(公告)日:2012-08-28

    申请号:KR1020110014438

    申请日:2011-02-18

    CPC classification number: A61K38/20 A61K48/005 Y10S424/81

    Abstract: PURPOSE: A composition for preventing or treating immunological rejection diseases including IL-27 is provided to alleviate the immunological rejection disease by suppressing rejection towards the host after the transplanted cell or organ is engrafted. CONSTITUTION: A composition for preventing or treating immunological rejection diseases includes IL-27 as an active component. The IL-27 has amino acid sequence described in the sequence number 1(SEQ ID NO:1). The composition for preventing or treating immunological rejection diseases includes a vector containing polynucleotide which codes the IL-27 as an active ingredient. The polynucleotide has the base sequence described in the sequence number 2. The immunological rejection disease is graft-versus-host disease.

    Abstract translation: 目的:提供一种用于预防或治疗免疫排斥疾病(包括IL-27)的组合物,用于通过在移植的细胞或器官移植后抑制对宿主的排斥来减轻免疫排斥疾病。 构成:用于预防或治疗免疫排斥疾病的组合物包括IL-27作为活性成分。 IL-27具有序列号1(SEQ ID NO:1)中描述的氨基酸序列。 用于预防或治疗免疫排斥疾病的组合物包括编码IL-27作为活性成分的含有多核苷酸的载体。 多核苷酸具有序列号2中描述的碱基序列。免疫排斥疾病是移植物抗宿主病。

    IL-27로 유도된 p53을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물
    3.
    发明公开
    IL-27로 유도된 p53을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물 无效
    用于预防或治疗包含IL-27诱导的P53的免疫疾病的组合物

    公开(公告)号:KR1020120095063A

    公开(公告)日:2012-08-28

    申请号:KR1020110014466

    申请日:2011-02-18

    CPC classification number: A61K38/1758 A61K38/20 C07K14/4713 C07K14/4746

    Abstract: PURPOSE: A composition for preventing or treating immunization diseases including p53 induced by il-27 is provided to increase expression of p53 by getting stimulation of the IL-27 and to enhance arthritis in animal models according to the expression of p53. CONSTITUTION: A composition for preventing or treating immunization diseases includes p53. The p53 has amino acid sequence described in the sequence number 1(SEQ ID NO:1) or 2. The composition additionally includes the interleukin-27(IL-27). The interleukin-27(IL-27) multiplies the activities of the gene expression of p53 or the p53 protein. The composition for preventing or treating immunization diseases includes a promoter and a vector containing polynucleotide which codes the p53. The polynucleotide has the base sequence described in the sequence number 3 or 4.

    Abstract translation: 目的:提供一种用于预防或治疗由il-27诱导的免疫疾病包括p53的组合物,以通过刺激IL-27并根据p53的表达增强动物模型中的关节炎来增加p53的表达。 构成:用于预防或治疗免疫疾病的组合物包括p53。 p53具有序列号1(SEQ ID NO:1)或2所述的氨基酸序列。该组合物另外包括白细胞介素-27(IL-27)。 白介素-27(IL-27)将p53或p53蛋白的基因表达的活性相乘。 用于预防或治疗免疫疾病的组合物包括编码p53的启动子和含有多核苷酸的载体。 多核苷酸具有序列号3或4中描述的碱基序列。

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