公开(公告)号：KR1020140094295A

公开(公告)日：2014-07-30

申请号：KR1020130006929

申请日：2013-01-22

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  조항수 ,  최두진 ,  정미자

IPC: A61K36/07 ,  A61K31/70 ,  A61P25/28 ,  A61P25/00

CPC classification number: A61K31/716 ,  A23L29/035 ,  A23V2200/322 ,  A61K36/07

Abstract: Provided are an anti-Alzheimer′s pharmaceutical composition and a functional health food for alleviating Alzheimer′s, wherein a water-soluble monomer derived from a hot water extract of a Phellinus linteus fruit body is contained as an active ingredient. The pharmaceutical composition and functional health food according to the present invention inhibit the activity of beta secretase related to the production and accumulation of beta amyloid peptides which are considered to be the cause of Alzheimer′s. Accordingly, the pharmaceutical composition containing water-soluble polysaccharides can be utilized as a medical product or a functional health food for preventing or treating Alzheimer′s.

Abstract translation: 提供抗阿尔茨海默氏病药物组合物和用于缓解阿尔茨海默病的功能保健食品，其中含有源自桑黄果实体的热水提取物的水溶性单体作为活性成分。 根据本发明的药物组合物和功能保健食品抑制与被认为是阿尔茨海默氏病原因的β淀粉样蛋白肽的产生和积累相关的β分泌酶的活性。 因此，含有水溶性多糖的药物组合物可以用作医疗产品或用于预防或治疗阿尔茨海默病的功能保健食品。

公开(公告)号：KR1020120051928A

公开(公告)日：2012-05-23

申请号：KR1020100113306

申请日：2010-11-15

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  문혜란 ,  정미자 ,  조수묵

IPC: A61K36/185 ,  A61P29/00 ,  A61P11/02 ,  A61P27/02

Abstract: PURPOSE: A pharmacological composition containing acorn extract is provided to reduce production of iNOS, COX-2 and nitric oxide and to ensure anti-inflammatory effect. CONSTITUTION: A composition with an anti-inflammatory activity contains 0.1-250 ug/ml of water or alcohol extract of acorn. The composition is used for treating or preventing rhinitis, bronchitis, hepatitis, pleurisy, peritonitis, arthritis(rheumatoid arthritis, psoriatic arthritis, cute gouty arthritis), asthma, chondromalacia, and coalescing spondylitis. The composition further contains pharmaceutically or sitologically acceptable carrier, excipient, or diluents.

Abstract translation: 目的：提供含有橡胶提取物的药理组合物，以减少iNOS，COX-2和一氧化氮的产生，并确保抗炎作用。 构成：具有抗炎活性的组合物含有0.1-250ug / ml的橡子的水或醇提取物。 该组合物用于治疗或预防鼻炎，支气管炎，肝炎，胸膜炎，腹膜炎，关节炎（类风湿性关节炎，银屑病关节炎，可爱的痛风性关节炎），哮喘，软骨软化症和聚结性脊椎炎。 该组合物进一步含有药学上或可视觉上可接受的载体，赋形剂或稀释剂。

公开(公告)号：KR1020130047855A

公开(公告)日：2013-05-09

申请号：KR1020110112653

申请日：2011-11-01

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  정미자 ,  박제권

IPC: A61K31/722 ,  A61K31/70 ,  A61P11/06 ,  A61P11/00

CPC classification number: A61K31/702 ,  A23L29/30 ,  A23V2200/314 ,  Y10S514/826

Abstract: PURPOSE: A low molecular weight chitosan oilgosaccharide with anti-asthma activity, and a pharmaceutical composition containing the same are provided to ensure a high anti-asthma effect, and to prevent and treat asthma. CONSTITUTION: A pharmaceutical composition for preventing or treating asthma contains chitosan oligosaccharide as an active ingredient. The low molecular weight chitosan oligosaccharide contains 3-5 glycosamines. The low molecular weight chitosan oligosaccharide suppresses the expression of IL-4, IL-5, IL-13, and TNF-alpha in a lung tissue and bronchoalveolar lavage fluid. The low molecular weight chitosan oligosaccharide is administered in a concentration of 5-20 mg/kg body weight.

Abstract translation: 目的：提供具有抗哮喘活性的低分子量壳聚糖油糖和含有其的药物组合物，以确保高抗哮喘作用，并预防和治疗哮喘。 构成：用于预防或治疗哮喘的药物组合物含有壳聚糖寡糖作为活性成分。 低分子量壳聚糖寡糖含有3-5个糖胺。 低分子量壳聚糖寡糖抑制肺组织和支气管肺泡灌洗液中IL-4，IL-5，IL-13和TNF-α的表达。 低分子量壳聚糖寡糖以5-20mg / kg体重的浓度施用。

公开(公告)号：KR1020120133888A

公开(公告)日：2012-12-11

申请号：KR1020110052797

申请日：2011-06-01

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  문혜란 ,  정미자 ,  조수묵

IPC: A61K36/49 ,  A61P11/06 ,  A61P35/00

CPC classification number: A61K36/49 ,  A23V2200/314 ,  A61K2236/33 ,  Y10S514/826

Abstract: PURPOSE: A pharmacological composition and a medicinal product containing Quercus acutissima CARR extract which prevents or treats asthma is provided to ensure an anti-asthma effect with safety and to be used in medicinal products or health functional foods. CONSTITUTION: A pharmacological composition for anti-asthma contains 50-500 mg/kg of alcohol extract of Quercus acutissima CARR as an active ingredient. The extract suppresses the expression of Bronchoalveolar lavage fluid(BALF) and IL-4, IL-13, TNF-alpha cytokines in lung tissues. The extract contains tannic acids and is prepared using non-polar solvent. A medicinal product for preventing or treating asthma contains the pharmacological composition as an active ingredient and pharmaceutically acceptable carriers.

Abstract translation: 目的：提供防止或治疗哮喘的药物组合物和含有槲皮素CARR提取物的药用成分，以确保抗哮喘作用，并可用于药用产品或保健功能食品。 构成：抗哮喘药理组合物含有50-500mg / kg的槲皮素CARR的醇提取物作为活性成分。 提取物抑制肺组织中支气管肺泡灌洗液（BALF）和IL-4，IL-13，TNF-α细胞因子的表达。 提取物含有单宁酸，并使用非极性溶剂制备。 用于预防或治疗哮喘的药用产品含有药理组合物作为活性成分和药学上可接受的载体。

公开(公告)号：KR101303198B1

公开(公告)日：2013-09-03

申请号：KR1020100113306

申请日：2010-11-15

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  문혜란 ,  정미자 ,  조수묵

IPC: A61K36/185 ,  A61P29/00 ,  A61P11/02 ,  A61P27/02

Abstract: 본 발명은 염증질환을 예방 및 치료할 수 있는 항염증 활성을 갖는 도토리 추출물 및 이 추출물을 함유하는 약리적 조성물에 관한 것이다. 본 발명에 따르면, 대식세포에서 내독소인 LPS에 의해 증가된 iNOS, COX-2 그리고 nitric oxide의 생성량을 감소시키는 도토리 에탄올 추출물이 비염, 지관지염, 간염, 관절염, 천식, 아토피성 피부염 등 염증반응 관련 질병들에 대해 항염증 효과를 발휘하면서 이들 질병 예방과 치료에 도움을 줄 수 있다는 점을 확인하였다.