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公开(公告)号：WO2014030898A1
公开(公告)日：2014-02-27
申请号：PCT/KR2013/007440
申请日：2013-08-20
Applicant: 강원대학교산학협력단
CPC classification number: C07K5/1019 , A61K8/64 , A61K38/06 , A61K38/07 , A61Q19/08 , C07K5/0804 , C07K5/0817 , C07K5/0819 , C07K5/101
Abstract: 본 발명은 NF-κB의 p65 서브유닛으로부터 유래된 작은 펩타이드 단편(small peptide fragments) 및 이를 포함하는 약학 조성물 또는 화장료 조성물을 제공한다. 상기 펩타이드는 NF-κB의 전사 촉진 기능을 조절함으로써 NF-κB 억제 활성을 갖는다. 상기 펩타이드들은 NF-κB 활성에 의해 발현이 유도되는 다양한 염증 매개분자의 발현을 억제하고 백혈구의 혈관외유출을 억제함으로써 항-염증 활성을 갖는다. 특히, 상기 펩타이드들은 피부 염증 및 피부 노화에 대한 우수한 억제활성을 갖는다. 또한, 상기 펩타이드들은 혈관신생 및 암세포의 바닥막 침윤을 억제함으로써 암세포의 성장과 전이에 대한 억제 활성을 갖는다.
Abstract translation: 本发明提供衍生自NF-κB的p65亚基的小肽片段和包含其的药物组合物或化妆品组合物。 肽调节NF-κB的反式激活功能以具有NF-κB的抑制活性。 肽抑制各种炎性介质分子的表达，其表达由NF-κB活性诱导，并抑制白血细胞外渗以具有抗炎活性。 特别地，肽对皮肤炎症和皮肤老化具有优异的抑制活性。 此外，肽抑制癌细胞的基底膜的血管化和渗透，从而具有抑制癌细胞生长和转移的活性。
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公开(公告)号：KR1020120003832A
公开(公告)日：2012-01-11
申请号：KR1020110122052
申请日：2011-11-22
Applicant: 강원대학교산학협력단
IPC: A61K38/16 , A61K31/711 , A61P35/00
Abstract: PURPOSE: A composition containing NADPH oxidase complex protein and/or diphenylene iodonium and/or derivative thereof is provided to treat and diagnose cancer. CONSTITUTION: A composition for preventing and treating cancer contains therapeutically effective amount of diphenylene iodonium, derivative thereof, or pharmaceutically acceptable salt thereof as an active ingredient. The therapeutically effective amount is 1mg/kg to 1000 mg/kg. The composition is administered by combining with an anti-cancer drug such as cisplatin, taxol, taxotere, doxorubicin, etoposide, gleevec, arimidex, tamoxifern, epirubicin, adriamycin, or valstar.
Abstract translation: 目的：提供含有NADPH氧化酶复合蛋白和/或二亚苯基碘和/或其衍生物的组合物以治疗和诊断癌症。 构成：用于预防和治疗癌症的组合物含有治疗有效量的二亚苯基碘鎓，其衍生物或其药学上可接受的盐作为活性成分。 治疗有效量为1mg / kg至1000mg / kg。 组合物通过与抗癌药物如顺铂，紫杉醇，泰索帝，多柔比星，依托泊苷，格列卫，阿昔洛韦，他莫昔芬，表柔比星，阿霉素或valstar组合施用。
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公开(公告)号：KR101877951B1
公开(公告)日：2018-07-12
申请号：KR1020170011075
申请日：2017-01-24
Applicant: 강원대학교산학협력단
IPC: C07J63/00 , C07J53/00 , A61K31/192
CPC classification number: C07J63/008 , A61K31/192 , C07J53/002
Abstract: 본발명은 PIM(Proviral Integration site for Moloney murine leukemia virus)-1 키나아제를표적으로하는화합물인셀라스트롤(Celastrol)에관한것으로, 본발명을통하여알 수있는바와같이 celastrol은 Pim-1 kinase의 ATP-binding 결합부위에직접결합하여유비퀴틴화를유도하고유비퀴틴화된 Pim-1은 26S proteasome에의해분해됨으로써 cisplatin에대한암 세포의내성을완화시키는효과가있다.
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5.发明授权
公开(公告)号：KR101594032B1
公开(公告)日：2016-02-15
申请号：KR1020120092400
申请日：2012-08-23
Applicant: 강원대학교산학협력단
CPC classification number: C07K5/1019 , A61K8/64 , A61K38/06 , A61K38/07 , A61Q19/08 , C07K5/0804 , C07K5/0817 , C07K5/0819 , C07K5/101
Abstract: 본발명은 NF-κB의 p65 서브유닛으로부터유래된작은펩타이드단편(small peptide fragments)을유효성분으로포함하는염증또는피부노화의예방또는치료용약학조성물을제공한다. 또한, 본발명은상기펩타이드단편을포함하는염증또는피부노화의개선을위한화장료조성물을제공한다. 상기펩타이드는 NF-κB 활성에의해발현이유도되는다양한염증매개분자의발현을억제하고백혈구의혈관외유출을억제함으로써항염증활성을갖는다. 또한, 자외선자극에의해증가되는염증매개인자인자로서, NF-κB 에의해전사조절되는염증매개인자인 MMP-1, TNF-α, 및 IL-1α의발현을억제하고, 염증매개분자인 PGE생성및 이를매개하는효소인 COX-2의발현을억제함으로써, 피부광노화억제활성을갖는다.
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Patent Agency Ranking6.发明公开
公开(公告)号：KR1020140026782A
公开(公告)日：2014-03-06
申请号：KR1020120092400
申请日：2012-08-23
Applicant: 강원대학교산학협력단
CPC classification number: C07K5/1019 , A61K8/64 , A61K38/06 , A61K38/07 , A61Q19/08 , C07K5/0804 , C07K5/0817 , C07K5/0819 , C07K5/101
Abstract: The present invention provides a pharmaceutical composition for preventing or treating inflammation or skin aging which includes small peptide fragments derived from p65 subunits of NF-κB as an active ingredient. In addition, the present invention provides a cosmetic composition for improving inflammation or skin aging which includes the peptide fragments. The peptide suppresses expression of various inflammation mediated molecules in which expression is induced by activities of the NF-κB and suppresses extravasation of white blood cells. In addition, the cosmetic composition suppresses expression of MMP-1, TNF-α, and IL-1α which are inflammation mediators which are transcriptionally controlled by the NF-κB as the inflammation mediator which is increased by ultraviolet stimulation and suppresses production of PGE2 which is the inflammation mediated molecules and expression of COX-2 which is an enzyme which mediates the same so that the cosmetic composition has skin photoaging suppression activities.
Abstract translation: 本发明提供一种预防或治疗炎症或皮肤老化的药物组合物，其包含衍生自NF-κB的p65亚基的小肽片段作为活性成分。 此外，本发明提供了包含肽片段的用于改善炎症或皮肤老化的化妆品组合物。 该肽抑制各种炎症介导的分子的表达，其中表达由NF-κB的活性诱导并抑制白细胞的外渗。 此外，化妆品组合物抑制作为通过紫外线刺激而增加的NF-κB转录控制的炎症介质的MMP-1，TNF-α和IL-1α的表达，抑制PGE2的产生， 是炎症介导的分子和COX-2的表达，COX-2是介导相同的酶，使得化妆品组合物具有皮肤光老化抑制活性。
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公开(公告)号：KR1020120114140A
公开(公告)日：2012-10-16
申请号：KR1020110103166
申请日：2011-10-10
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A method for preparing recombinant plasmid using heme oxidase-1 gene is provided to screen natural products with anti-obesity and/or anti-inflammatory functions. CONSTITUTION: A recombinant plasmid is used for suppressing the expression of heme oxidase-1 gene. A plasmid vector contains an RNA promoter. The hame oxidase-1 gene has a base of sequence number 1. A base for inducing hairpin structure is a base of sequence number 2 or 3. A method for producing adipocytes which suppresses heme oxidase-1 gene expression comprises a step of transduction of the recombinant plasmid to adipocyte cell line. A method for detecting an anti-obesity candidate from a natural product comprises: a step of treating the natural product to the adipocytes; a step of measuring the expression level of the heme oxidase-1 gene; and a step of selecting the natural product as an anti-obesity candidate material when the expression of heme oxidase-1 gene is reduced. [Reference numerals] (AA) Beta-actin
Abstract translation: 目的：提供使用血红素氧化酶-1基因制备重组质粒的方法，筛选具有抗肥胖和/或抗炎功能的天然产物。 构成：重组质粒用于抑制血红素氧化酶-1基因的表达。 质粒载体含有RNA启动子。 hame氧化酶-1基因具有序列号1的碱基。用于诱导发夹结构的碱基是序列号2或3的碱基。一种抑制血红素氧化酶-1基因表达的脂肪细胞的制备方法包括转导 重组质粒到脂肪细胞系。 从天然产物检测抗肥胖症候选物的方法包括：将天然产物处理至脂肪细胞的步骤; 测定血红素氧化酶-1基因表达水平的步骤; 并且当血红素氧化酶-1基因的表达降低时，选择天然产物作为抗肥胖候选物质的步骤。 （参考号）（AA）β-肌动蛋白
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公开(公告)号：KR1020110088733A
公开(公告)日：2011-08-04
申请号：KR1020100008374
申请日：2010-01-29
Applicant: 강원대학교산학협력단
IPC: A61K38/16 , A61K31/711 , A61P35/00
CPC classification number: A61K38/16 , G01N2800/365
Abstract: PURPOSE: A composition containing NADPH oxidase composite protein is provided to induce apoptosis of cancer cells and to treat and diagnose cancer. CONSTITUTION: A composition for diagnosing cancer contains polypeptides selected from the group consisting of NADPH oxidase composite(Nox) 1, NADPH oxidase complex(Nox)4, and NADPH oxidase composite(Nox) 5, and functional mutants as an active ingredient. The Nox 1, Nox 4, and Nox 5 have an amino acid sequence of sequence numbers 19, 20, and 21.
Abstract translation: 目的：提供含有NADPH氧化酶复合蛋白的组合物诱导癌细胞凋亡并治疗和诊断癌症。 构成：用于诊断癌症的组合物含有选自NADPH氧化酶复合物（Nox）1，NADPH氧化酶复合物（Nox）4和NADPH氧化酶复合物（Nox）5的多肽和作为活性成分的功能性突变体。 Nox 1，Nox 4和Nox 5具有序列号19,20和21的氨基酸序列。
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公开(公告)号：KR101497146B1
公开(公告)日：2015-03-03
申请号：KR1020140011318
申请日：2014-01-29
Applicant: 강원대학교산학협력단 , 차의과학대학교 산학협력단
IPC: A61K31/404 , A61K31/40 , A61P35/00
CPC classification number: A61K31/4045
Abstract: 본 발명은 신규한 암세포 전이활성 억제용 조성물에 관한 것이다.
Abstract translation: 本发明涉及抑制癌细胞转移活性的新型组合物。 本发明的目的是提供抑制癌转移的候选物质，其阻碍TGF-β衍生的EMT和癌细胞的迁移。 为此，提供了包含化学式1的化合物的抗癌药物组合物。根据本发明，作为MEK5抑制剂的BIX02189阻碍TGF-β衍生的EMT，从而具有抑制作用的活性 癌转移。
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10.发明授权
公开(公告)号：KR101489844B1
公开(公告)日：2015-02-06
申请号：KR1020130074658
申请日：2013-06-27
Applicant: 강원대학교산학협력단 , 가천대학교 산학협력단
IPC: A01K67/027 , C12N15/12 , G01N33/15
Abstract: 본 발명은 14-3-3 시그마 유전자 결손 마우스, 이를 이용한 인 비보 패혈증 연구모델 개발 방법 및 그 응용에 관한 것이다.
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