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公开(公告)号：KR101506642B1
公开(公告)日：2015-03-27
申请号：KR1020140011319
申请日：2014-01-29
Applicant: 강원대학교산학협력단 , 차의과학대학교 산학협력단
IPC: A61K31/404 , A61K31/40 , A61P35/00
CPC classification number: A61K31/4045
Abstract: 본 발명은 신규한 TGF-beta 수용체 유형 I 저해용 조성물에 관한 것이다.
Abstract translation: 本发明涉及用于抑制I型TGF-β受体的新型组合物。更具体地，提供了抑制作为活性物质的化学式1化合物的SMAD（Sma和Mad相关蛋白）3的磷酸化增加的组合物 成分。 根据本发明，BIX02189抑制细胞实验中TGF-β信号的传递，而不管MEK 5的抑制，并且可以通过使用计算机虚拟模型的域对接分析来竞争性地结合TbRI受体的ATP结合位点。
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Patent Agency Ranking
公开(公告)号：KR101497146B1
公开(公告)日：2015-03-03
申请号：KR1020140011318
申请日：2014-01-29
Applicant: 강원대학교산학협력단 , 차의과학대학교 산학협력단
IPC: A61K31/404 , A61K31/40 , A61P35/00
CPC classification number: A61K31/4045
Abstract: 본 발명은 신규한 암세포 전이활성 억제용 조성물에 관한 것이다.
Abstract translation: 本发明涉及抑制癌细胞转移活性的新型组合物。 本发明的目的是提供抑制癌转移的候选物质，其阻碍TGF-β衍生的EMT和癌细胞的迁移。 为此，提供了包含化学式1的化合物的抗癌药物组合物。根据本发明，作为MEK5抑制剂的BIX02189阻碍TGF-β衍生的EMT，从而具有抑制作用的活性 癌转移。
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公开(公告)号：KR101356139B1
公开(公告)日：2014-01-24
申请号：KR1020110103166
申请日：2011-10-10
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 HO-1 단백질의 항비만 관련 기능을 검증하고 ho-1 유전자 발현 조절 시스템을 도입한 전구체 지방세포주 제작 및 이를 탐색 시스템으로 사용하여 항비만 또는 항염증 활성을 함유하는 물질의 스크리닝 방법에 관한 것이다.
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公开(公告)号：KR101140391B1
公开(公告)日：2012-05-03
申请号：KR1020110031539
申请日：2011-04-06
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A method for screening a material containing a material with anti-obesity or anti-inflammatory activities using HO-1 protein is provided. CONSTITUTION: A method for reducing adipocyte differentiation comprises a step of overexpressing heme oxidase-1 genes in heme oxidase-1 gene-overexpressing adipocytes prepared by introducing a recombinant vector containing heme oxidase-1 gene with a base sequence of sequence number 1 into precursor adipocyte cell line. A method for searching an anti-obesity candidate from natural products comprises: a step of treating the natural products to the heme oxidase-1 gene overexpressing adipocytes; a step of measuring expression level of the heme oxidase-1 gene; and a step of selecting a natural product as an anti-obesity candidate in case that the heme oxidase-1 gene expression is reduced.
Abstract translation: 目的：提供使用HO-1蛋白筛选含有抗肥胖或抗炎活性物质的材料的方法。 构成：减少脂肪细胞分化的方法包括通过将含有序列1的碱基序列的含有血红素氧化酶-1基因的重组载体导入前体脂肪细胞而制备的血红素氧化酶-1基因过表达的脂肪细胞中过表达血红素氧化酶-1基因的步骤 细胞系。 从天然产物中搜索抗肥胖症候选者的方法包括：将天然产物处理过量表达脂肪细胞的血红素氧化酶-1基因的步骤; 测定血红素氧化酶-1基因表达水平的步骤; 在血红素氧化酶-1基因表达降低的情况下选择天然产物作为抗肥胖症候选者的步骤。
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公开(公告)号：KR101877951B1
公开(公告)日：2018-07-12
申请号：KR1020170011075
申请日：2017-01-24
Applicant: 강원대학교산학협력단
IPC: C07J63/00 , C07J53/00 , A61K31/192
CPC classification number: C07J63/008 , A61K31/192 , C07J53/002
Abstract: 본발명은 PIM(Proviral Integration site for Moloney murine leukemia virus)-1 키나아제를표적으로하는화합물인셀라스트롤(Celastrol)에관한것으로, 본발명을통하여알 수있는바와같이 celastrol은 Pim-1 kinase의 ATP-binding 결합부위에직접결합하여유비퀴틴화를유도하고유비퀴틴화된 Pim-1은 26S proteasome에의해분해됨으로써 cisplatin에대한암 세포의내성을완화시키는효과가있다.
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公开(公告)号：KR1020120114140A
公开(公告)日：2012-10-16
申请号：KR1020110103166
申请日：2011-10-10
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A method for preparing recombinant plasmid using heme oxidase-1 gene is provided to screen natural products with anti-obesity and/or anti-inflammatory functions. CONSTITUTION: A recombinant plasmid is used for suppressing the expression of heme oxidase-1 gene. A plasmid vector contains an RNA promoter. The hame oxidase-1 gene has a base of sequence number 1. A base for inducing hairpin structure is a base of sequence number 2 or 3. A method for producing adipocytes which suppresses heme oxidase-1 gene expression comprises a step of transduction of the recombinant plasmid to adipocyte cell line. A method for detecting an anti-obesity candidate from a natural product comprises: a step of treating the natural product to the adipocytes; a step of measuring the expression level of the heme oxidase-1 gene; and a step of selecting the natural product as an anti-obesity candidate material when the expression of heme oxidase-1 gene is reduced. [Reference numerals] (AA) Beta-actin
Abstract translation: 目的：提供使用血红素氧化酶-1基因制备重组质粒的方法，筛选具有抗肥胖和/或抗炎功能的天然产物。 构成：重组质粒用于抑制血红素氧化酶-1基因的表达。 质粒载体含有RNA启动子。 hame氧化酶-1基因具有序列号1的碱基。用于诱导发夹结构的碱基是序列号2或3的碱基。一种抑制血红素氧化酶-1基因表达的脂肪细胞的制备方法包括转导 重组质粒到脂肪细胞系。 从天然产物检测抗肥胖症候选物的方法包括：将天然产物处理至脂肪细胞的步骤; 测定血红素氧化酶-1基因表达水平的步骤; 并且当血红素氧化酶-1基因的表达降低时，选择天然产物作为抗肥胖候选物质的步骤。 （参考号）（AA）β-肌动蛋白
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