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公开(公告)号：KR1020140136843A
公开(公告)日：2014-12-01
申请号：KR1020130057429
申请日：2013-05-21
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to a composition for improving, treating or preventing neurodegenerative disease containing an oenanthe javanica extract as an active ingredient wherein the composition of the present invention increases the proliferation and differentiation of endogenous neural stem cells, which efficiently induces the regeneration of neuron cells and accordingly treats, improves or prevents neurodegenerative disease caused by neuron cells damaged by aging or brain diseases and functional problems like memory loss and cognitive dysfunction. In the present invention, the composition uses natural substances whose safety is recognized and which have little possibility of generating side effects, so the composition can be widely used for treating, improving or preventing neurodegenerative disease.
Abstract translation: 本发明涉及一种用于改善，治疗或预防神经变性疾病的组合物，其含有爪哇爪提取物作为活性成分，其中本发明的组合物增加内源性神经干细胞的增殖和分化，其有效诱导神经元细胞的再生 因此治疗，改善或预防由衰老或脑部疾病以及如记忆丧失和认知功能障碍等功能性问题引起的神经元细胞引起的神经变性疾病。 在本发明中，组合物使用其安全性被认可并且几乎不产生副作用的天然物质，因此该组合物可广泛用于治疗，改善或预防神经变性疾病。
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公开(公告)号：KR1020170096532A
公开(公告)日：2017-08-24
申请号：KR1020160018036
申请日：2016-02-16
Applicant: 강원대학교산학협력단
Abstract: 백미추출물을포함하는아토피피부염치료용조성물에관한것으로, 더욱상세하게는백미추출물을포함하는조성물의칼시뉴린조절단백질발현유도와아토피피부염을포함한염증억제효과에관한것이다.
Abstract translation: 本发明涉及用于治疗特应性皮炎的组合物，更具体地说，涉及包含用于诱导钙调磷酸酶调节蛋白质表达的白米提取物和包括特应性皮炎的炎症抑制作用的组合物。
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公开(公告)号：KR1020130089030A
公开(公告)日：2013-08-09
申请号：KR1020120010355
申请日：2012-02-01
Applicant: 강원대학교산학협력단
IPC: A61K31/404 , A61K31/40 , A61P35/00
CPC classification number: A61K31/409
Abstract: PURPOSE: A pharmaceutical composition for overcoming resistance to an anticancer agent is provided to suppress the activity of hemo oxygenase (HO) increased in cancer cells using methyl pheophorbide (MPP), thereby remarkably increasing apoptotic sensitivity in cancer cells with anticancer agent resistance. CONSTITUTION: A pharmaceutical composition for overcoming resistance to an anticancer agent contains MPP as an active ingredient. The anticancer agent is cisplatin. The effective concentration of MPP is 10 uM. A composition for suppressing HO contains MPP as an active ingredient.
Abstract translation: 目的：提供一种克服抗癌剂抗性的药物组合物，以抑制癌细胞中使用甲基偏硼酸（MPP）增加的血红素加氧酶（HO）的活性，从而显着增加抗癌剂抗性的癌细胞的凋亡敏感性。 构成：克服抗癌剂抗性的药物组合物含有MPP作为活性成分。 抗癌剂是顺铂。 MPP的有效浓度为10uM。 用于抑制HO的组合物含有MPP作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR101140391B1
公开(公告)日：2012-05-03
申请号：KR1020110031539
申请日：2011-04-06
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A method for screening a material containing a material with anti-obesity or anti-inflammatory activities using HO-1 protein is provided. CONSTITUTION: A method for reducing adipocyte differentiation comprises a step of overexpressing heme oxidase-1 genes in heme oxidase-1 gene-overexpressing adipocytes prepared by introducing a recombinant vector containing heme oxidase-1 gene with a base sequence of sequence number 1 into precursor adipocyte cell line. A method for searching an anti-obesity candidate from natural products comprises: a step of treating the natural products to the heme oxidase-1 gene overexpressing adipocytes; a step of measuring expression level of the heme oxidase-1 gene; and a step of selecting a natural product as an anti-obesity candidate in case that the heme oxidase-1 gene expression is reduced.
Abstract translation: 目的：提供使用HO-1蛋白筛选含有抗肥胖或抗炎活性物质的材料的方法。 构成：减少脂肪细胞分化的方法包括通过将含有序列1的碱基序列的含有血红素氧化酶-1基因的重组载体导入前体脂肪细胞而制备的血红素氧化酶-1基因过表达的脂肪细胞中过表达血红素氧化酶-1基因的步骤 细胞系。 从天然产物中搜索抗肥胖症候选者的方法包括：将天然产物处理过量表达脂肪细胞的血红素氧化酶-1基因的步骤; 测定血红素氧化酶-1基因表达水平的步骤; 在血红素氧化酶-1基因表达降低的情况下选择天然产物作为抗肥胖症候选者的步骤。
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公开(公告)号：KR101877951B1
公开(公告)日：2018-07-12
申请号：KR1020170011075
申请日：2017-01-24
Applicant: 강원대학교산학협력단
IPC: C07J63/00 , C07J53/00 , A61K31/192
CPC classification number: C07J63/008 , A61K31/192 , C07J53/002
Abstract: 본발명은 PIM(Proviral Integration site for Moloney murine leukemia virus)-1 키나아제를표적으로하는화합물인셀라스트롤(Celastrol)에관한것으로, 본발명을통하여알 수있는바와같이 celastrol은 Pim-1 kinase의 ATP-binding 결합부위에직접결합하여유비퀴틴화를유도하고유비퀴틴화된 Pim-1은 26S proteasome에의해분해됨으로써 cisplatin에대한암 세포의내성을완화시키는효과가있다.
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公开(公告)号：KR1020120114140A
公开(公告)日：2012-10-16
申请号：KR1020110103166
申请日：2011-10-10
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A method for preparing recombinant plasmid using heme oxidase-1 gene is provided to screen natural products with anti-obesity and/or anti-inflammatory functions. CONSTITUTION: A recombinant plasmid is used for suppressing the expression of heme oxidase-1 gene. A plasmid vector contains an RNA promoter. The hame oxidase-1 gene has a base of sequence number 1. A base for inducing hairpin structure is a base of sequence number 2 or 3. A method for producing adipocytes which suppresses heme oxidase-1 gene expression comprises a step of transduction of the recombinant plasmid to adipocyte cell line. A method for detecting an anti-obesity candidate from a natural product comprises: a step of treating the natural product to the adipocytes; a step of measuring the expression level of the heme oxidase-1 gene; and a step of selecting the natural product as an anti-obesity candidate material when the expression of heme oxidase-1 gene is reduced. [Reference numerals] (AA) Beta-actin
Abstract translation: 目的：提供使用血红素氧化酶-1基因制备重组质粒的方法，筛选具有抗肥胖和/或抗炎功能的天然产物。 构成：重组质粒用于抑制血红素氧化酶-1基因的表达。 质粒载体含有RNA启动子。 hame氧化酶-1基因具有序列号1的碱基。用于诱导发夹结构的碱基是序列号2或3的碱基。一种抑制血红素氧化酶-1基因表达的脂肪细胞的制备方法包括转导 重组质粒到脂肪细胞系。 从天然产物检测抗肥胖症候选物的方法包括：将天然产物处理至脂肪细胞的步骤; 测定血红素氧化酶-1基因表达水平的步骤; 并且当血红素氧化酶-1基因的表达降低时，选择天然产物作为抗肥胖候选物质的步骤。 （参考号）（AA）β-肌动蛋白
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公开(公告)号：KR1020140102441A
公开(公告)日：2014-08-22
申请号：KR1020130015715
申请日：2013-02-14
Applicant: 강원대학교산학협력단
CPC classification number: A61K48/00 , A61K38/16 , Y10S514/886
Abstract: The present invention relates to an anti-inflammatory composition comprising 14-3-3 sigma gene and/or protein as an active ingredient. The 14-3-3 sigma gene is preferred to be composed of a base sequence of SEQ ID NO.1; and provided in the present invent is an anti-inflammatory composition comprising a 14-3-3 sigma protein as an active ingredient. In an embodiment of the present invention, the 14-3-3 sigma protein is preferred to be composed of a base sequence of SEQ ID NO. 2, but is not limited to the same; and provided in the present invention is an expression vector controlling inflammatory cytokine comprising the 14-3-3 sigma gene composed of SEQ ID NO.1 as an active ingredient.
Abstract translation: 本发明涉及包含14-3-3σ基因和/或蛋白质作为活性成分的抗炎组合物。 14-3-3 sigma基因优选由SEQ ID NO.1的碱基序列组成; 并且在本发明中提供的是包含14-3-3σ蛋白作为活性成分的抗炎组合物。 在本发明的一个实施方案中，14-3-3σ蛋白质优选由SEQ ID NO.1的碱基序列组成。 2，但不限于此; 在本发明中提供了控制炎性细胞因子的表达载体，其包含由SEQ ID NO.1组成的14-3-3 sigma基因作为活性成分。
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公开(公告)号：KR101356139B1
公开(公告)日：2014-01-24
申请号：KR1020110103166
申请日：2011-10-10
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 HO-1 단백질의 항비만 관련 기능을 검증하고 ho-1 유전자 발현 조절 시스템을 도입한 전구체 지방세포주 제작 및 이를 탐색 시스템으로 사용하여 항비만 또는 항염증 활성을 함유하는 물질의 스크리닝 방법에 관한 것이다.
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